| S Club 7 in Miami | BBC Children's and Education | 1999 | 1 | 13 | Comedy |
| S.W.A.T. | ABC | 1975–1976 | 2 | 37 | Crime |
| S.W.A.T. | CBS | 2017–2025 | 8 | 163 | Thriller |
| S.W.A.T. Exiles | Starz | 2026–on air | 2 | 10 | Crime |
| Sa Re Ga Ma Pa Challenge USA 2008 | Nickelodeon | 2008 | — | 13 | — |
| Sábado Gigante | Univision, Canal 13 | 1962–2015 | 53 | 2,778 | — |
| Saban’s Gulliver’s TravelsAnimated series | Syndication | 1992–1993 | 1 | 26 | Adventure |
| Sable | ABC | 1987–1988 | 1 | 7 | — |
| Sabrina's Secret LifeAnimated series | Syndication | 2003–2004 | 1 | 26 | Fantasy |
| Sabrina: Secrets of a Teenage WitchAnimated series | Discovery Family | 2013–2014 | 1 | 26 | Fantasy |
| Sabrina: The Animated SeriesAnimated series | ABC, UPN | 1999–2000 | 1 | 65 | Fantasy |
| Sabrina the Teenage WitchAnimated series | CBS | 1970–1974 | 2 | 31 | Fantasy |
| Sabrina, the Teenage Witch | ABC, The WB | 1996–2003 | 7 | 163 | Sitcom |
| Sacred Lies | | 2018–2020 | 2 | 20 | Horror |
| Sacrificio de Mujer | Venevisión | 2011 | — | 101 | Telenovela |
| SadatMiniseries | Syndication | 1983 | — | 2 | — |
| SAF3 | Syndication | 2013–2014 | 1 | 20 | Drama |
| Safe Harbor | The WB | 1999 | 1 | 10 | — |
| Saga of Western Man | ABC | 1963–1969 | — | — | Anthology |
| Sagwa the Chinese Siamese CatAnimated series | PBS Kids, Treehouse TV | 2001–2002 | 1 | 40 | Children's |
| Sail Away | Discovery Family | 2001 | 1 | 13 | Reality |
| Saint George | FX | 2014 | 1 | 10 | Sitcom |
| Saint X | Hulu | 2023–on air | 1 | 8 | Psychological thriller |
| Saints and Sinners | NBC | 1962–1963 | 1 | 18 | Drama |
| Saints & Sinners | MyNetworkTV | 2007 | — | 65 | — |
| Saints & Sinners | Bounce TV | 2016–2022 | 6 | 49 | LGBTQ |
| Saints & StrangersMiniseries | National Geographic | 2015 | — | 2 | — |
| Sale of the Century | NBC | 1969–1989 | — | — | Quiz show |
| Salem | WGN America | 2014–2017 | 3 | 36 | Paranormal |
| Salem's LotMiniseries | CBS | 1979 | 1 | 2 | Vampire |
| Salem's LotMiniseries | TNT | 2004 | — | 2 | Vampire |
| Sally | KSDK | 1983 | 19 | 3,820 | Talk show |
| Salt Fat Acid Heat | Netflix | 2018 | — | — | Cooking show |
| The Salt-N-Pepa Show | VH1 | 2007–2008 | 2 | 14 | Reality |
| Salty's Lighthouse | TLC | 1997–1998 | — | 41 | — |
| Salute Your Shorts | Nickelodeon | 1991–1992 | 2 | 26 | Teen sitcom |
| Salvage 1 | ABC | 1979 | 2 | 19 | Science fiction |
| Salvation | CBS | 2017–2018 | 2 | 26 | Thriller |
| Sam | CBS | 1978 | 1 | 6 | — |
| Sam & Cat | Nickelodeon | 2013–2014 | 1 | 36 | Teen sitcom |
| Sam and Friends | WRC-TV | 1955–1961 | 1 | 86 | Comedy |
| Sam Benedict | NBC | 1962–1963 | 1 | 28 | Legal drama |
| Sam's Game | Playboy TV | 2009 | — | — | — |
| Samantha Who? | ABC | 2007–2009 | 2 | 35 | Sitcom |
| Same Name | CBS | 2011 | 1 | 4 | Reality |
| Sammy | NBC | 2000 | 1 | 2 | — |
| Samson & Goliath | NBC | 1967–1968 | 1 | 20 | — |
| Samurai GirlMiniseries | Freeform | 2008 | 1 | 6 | Martial arts |
| Samurai JackAnimated series | Adult Swim | 2017 | 5 | 10 | Fantasy |
| Samurai RabbitAnimated series | Netflix | 2022–on air | — | — | Children's |
| San Francisco International Airport | NBC | 1970 | 1 | 7 | — |
| The San Pedro Beach Bums | ABC | 1977 | 1 | 11 | Sitcom |
| Sand Masters | Travel Channel | 2011–2012 | 2 | 25 | Reality |
| Sanders SidesWeb series | YouTube | 2016 | — | 28 | Comedy |
| The Sandman | Netflix | 2022–2025 | 2 | 23 | Drama |
| The Sandy Duncan Show | CBS | 1971 | — | 13 | Sitcom |
| Sanford | NBC | 1980–1981 | 2 | 26 | Sitcom |
| Sanford and Son | NBC | 1972–1977 | 6 | 136 | Sitcom |
| Sanford Arms | NBC | 1977 | 1 | 8 | Sitcom |
| Sanjay and CraigAnimated series | Nickelodeon | 2013–2016 | 3 | 45 | Comedy |
| Santa Barbara | NBC | 1984–1993 | 9 | 2,137 | Soap opera |
| Santa Clarita Diet | Netflix | 2017–2019 | 3 | 30 | Comedy horror |
| The Santa Clauses | Disney+ | 2022–on air | 2 | 12 | Christmas |
| Santa Inc.Animated series | HBO Max | 2021–on air | — | — | Adult animation |
| Santiago of the SeasAnimated series | Nickelodeon | 2020–2023 | 2 | 58 | — |
| Santo BugitoAnimated series | CBS | 1995–1996 | 1 | 13 | Children's |
| Sara | CBS | 1976 | 1 | 12 | — |
| Sarah Palin's Alaska | TLC | 2010–2011 | 1 | 9 | — |
| The Sarah Silverman Program | Comedy Central | 2007–2010 | 3 | 32 | LGBTQ |
| Sarge | NBC | 1971–1972 | 1 | 13 | Crime |
| Satisfaction | USA Network | 2014–2015 | 2 | 20 | Drama |
| Saturday Morning All Star Hits!Animated series | | 2021–on air | — | — | Adult animation |
| Saturday Night Live | NBC | 1975 | 52 | 1,010 | Stand-up comedy |
| Saturday Night Live Weekend Update Thursday | NBC | 2008–2017 | 3 | 8 | Comedy |
| Saturday Night Live with Howard Cosell | ABC | 1975–1976 | 1 | 18 | — |
| Saturday Night's Main Event | | 1985–2008 | — | — | Professional wrestling |
| Saturday SupercadeAnimated series | CBS | 1983–1984 | 2 | 26 | — |
| Saturdays | Disney Channel | 2023 | 1 | 15 | — |
| The Sauce | Fuse | 2007–2008 | — | — | — |
| Saul of the Mole Men | Adult Swim | 2007 | 1 | 20 | Comedy |
| Sausage Party: FoodtopiaAnimated series | Prime Video | 2024–on air | 2 | 16 | Comedy |
| Savage Builds | Science Channel | 2019–on air | — | — | — |
| The Savage DragonAnimated series | USA Network | 1995–1996 | 1 | 26 | Comedy |
| Savage U | MTV | 2012 | 1 | 12 | Talk show |
| Savannah | The WB | 1996–1997 | 2 | 34 | Soap opera |
| The Savant | Apple TV | 2027upcoming | — | — | Thriller |
| Save Me | NBC | 2013 | 1 | 7 | Sitcom |
| Save My Life: Boston Trauma | ABC | 2015 | 1 | 6 | Documentary |
| The Save-Ums | CBC Television | 2003–2006 | 2 | 78 | Animation |
| Saved | TNT | 2006 | 1 | 13 | Medical drama |
| Saved by the Bell | NBC | 1989–1993 | 4 | 86 | Teen sitcom |
| Saved by the Bell | Peacock | 2020–2021 | 2 | 20 | — |
| Saved by the Bell: The College Years | NBC | 1993–1994 | 1 | 19 | Teen sitcom |
| Saved by the Bell: The Junior High Years | Disney Channel | 1988–1989 | 1 | 14 | Sitcom |
| Saved by the Bell: The New Class | NBC | 1993–2000 | 6 | 143 | Sitcom |
| Saving Grace | TNT | 2007–2010 | 3 | 46 | Fantasy |
| Saving My Tomorrow | HBO | 2014–2017 | — | 6 | — |
| Say I Do | Netflix | 2020–on air | 1 | 8 | Reality |
| Say Nothing | Hulu | 2024–on air | — | 9 | Historical drama |
| Say What? Karaoke | MTV | 1998–2003 | — | — | Game show |
| Say Yes to the Dress | TLC | 2007 | 10 | 181 | Reality |
| Say Yes to the Dress: Atlanta | TLC | 2010–2018 | 6 | 102 | Reality |
| Say Yes to the Dress: Bridesmaids | TLC | 2011–2013 | 4 | 52 | Reality |
| Say Yes to the Dress: Randy Knows Best | TLC | 2011–2013 | 2 | 14 | — |
| ScamandaMiniseries | Hulu | 2025 | 1 | 4 | True crime |
| Scandal | ABC | 2012–2018 | 7 | 124 | LGBTQ |
| Scare Tactics | Syfy, Chiller | 2003–2013 | 4 | 114 | Reality |
| Scarecrow and Mrs. King | CBS | 1983–1987 | 4 | 88 | Drama |
| Scaredy Camp | Nickelodeon | 2002–2003 | 2 | 10 | Reality |
| Scaredy Cats | Netflix | 2021–on air | — | — | Fantasy |
| Scariest Places on Earth | Freeform | 2000–2006 | 3 | 41 | Documentary |
| ScarlettMiniseries | CBS | 1994 | 1 | 4 | Drama |
| Scarpetta | Prime Video | 2026–on air | 1 | 8 | Mystery |
| Scarred | MTV | 2007 | 2 | 20 | Reality |
| Scary Scooby FunniesAnimated series | ABC | 1984–1985 | 1 | — | — |
| Scattergories | NBC | 1993 | — | 105 | Game show |
| Scavengers ReignAnimated series | HBO Max | 2023–on air | 1 | 12 | Adventure |
| Scene of the Crime | CBS | 1991–1992 | 2 | 22 | Anthology |
| Scenes from a MarriageMiniseries | HBO | 2021 | — | 5 | Drama |
| Schlitz Playhouse of Stars | CBS | 1951–1959 | 8 | 377 | Anthology |
| Schmigadoon! | Apple TV | 2021–on air | 2 | 12 | — |
| The Scholar | ABC | 2005 | — | — | Reality |
| The School House | DuMont | 1949 | — | 14 | — |
| School of Rock | Nickelodeon | 2016–2018 | 3 | 45 | Music |
| School Pride | NBC | 2010 | 1 | 7 | Reality |
| School Spirits | Syfy | 2012 | 1 | 6 | — |
| School Spirits | Paramount+ | 2023–on air | 3 | 16 | Paranormal |
| Schooled | ABC | 2019–2020 | 2 | 34 | Sitcom |
| Schoolhouse Rock!Animated series | ABC | 1973–2009 | 7 | 64 | — |
| Sci Fi Science: Physics of the Impossible | Science Channel | 2009–2010 | 2 | 24 | — |
| Science Court | ABC | 1997–2000 | 3 | 29 | — |
| Science Fiction Theatre | Syndication | 1955–1957 | 2 | 78 | Science fiction |
| SciGirls | PBS Kids Go!, PBS | 2010–2020 | 4 | 34 | Live action & animation |
| The Scooby & Scrappy-Doo/Puppy HourAnimated series | ABC | 1982 | — | 13 | Comedy |
| Scooby-Doo and Guess Who?Animated series | Cartoon Network | 2019–2021 | 2 | 26 | Comedy |
| Scooby-Doo and Scrappy-DooAnimated series | ABC | 1979–1980 | 1 | 16 | Comedy |
| Scooby-Doo and Scrappy-DooAnimated series | ABC | 1980–1982 | 3 | 33 | — |
| The Scooby-Doo/Dynomutt HourAnimated series | ABC | 1976 | — | 16 | — |
| Scooby-Doo! Mystery IncorporatedAnimated series | Cartoon Network | 2010–2013 | 2 | 52 | Fantasy |
| The Scooby-Doo ShowAnimated series | ABC | 1976–1978 | 3 | 40 | Comedy |
| Scooby-Doo, Where Are You!Animated series | CBS | 1969–1970 | 2 | 25 | Comedy |
| Scooby-Doo, Where Are You Now! | The CW | 2021–on air | — | — | — |
| Scooby's All-Star Laff-A-LympicsAnimated series | ABC | 1977–1978 | — | 24 | Comedy |
| Scooby's Mystery FunhouseAnimated series | ABC | 1985–1986 | 1 | 21 | — |
| Scorch | CBS | 1992 | 1 | 6 | Sitcom |
| Scoreboard | DuMont | 1948–1949 | 1 | 52 | — |
| Scorned: Love Kills | Investigation Discovery | 2012–2016 | 4 | 58 | Documentary |
| Scorpion | CBS | 2014–2018 | 4 | 93 | Drama |
| Scotland Yard | ABC | 1953–1961 | 1 | 39 | — |
| Scott Baio Is 45...and Single | VH1 | 2007 | — | 7 | Reality |
| Scott Baio Is 46...and Pregnant | VH1 | 2008 | 1 | 9 | Reality |
| Scott the Woz | G4 | 2021–2022 | — | — | — |
| Scoundrels | ABC | 2010 | 1 | 8 | — |
| Scout's Safari | NBC, Discovery Kids | 2002–2004 | 2 | 26 | — |
| Scouted | E! | 2011–2012 | 1 | 8 | Reality |
| Scrabble | The CW, NBC | 1984 | 8 | 1,574 | Game show |
| Scrabble Showdown | Discovery Family | 2011–2012 | 1 | 30 | — |
| Scream | MTV | 2015–2019 | 3 | 30 | Mystery |
| Scream Queens | VH1 | 2008–2010 | 2 | 16 | Reality |
| Scream Queens | Fox | 2015–2016 | 2 | 23 | Comedy |
| Screen Directors Playhouse | NBC | 1955–1956 | 1 | 35 | — |
| Screen Gems Network | Syndication | 1999–2002 | — | — | — |
| The Screen Savers | TechTV | 1998–2005 | — | 1,300 | — |
| Scrubbing In | MTV | 2013 | 1 | 10 | Reality |
| Scrubs | ABC, NBC | 2001–2010 | 10 | 187 | Medical drama |
| Scrubs: InternsWeb series | ABC | 2009 | 1 | 12 | Comedy |
| Sea Change: The Gulf of Maine | PBS | 2024 | — | 3 | Documentary |
| Sea Hunt | Syndication | 1958–1961 | 4 | 155 | — |
| Sea Rescue | ABC | 2012–2018 | 3 | 54 | Educational |
| Seal Team | CBS, Paramount+ | 2017–2024 | 7 | 114 | Drama |
| Sealab 2020Animated series | NBC | 1972 | 1 | 13 | Adventure |
| Sealab 2021Animated series | Adult Swim | 2000–2005 | 4 | 52 | Sitcom |
| Sean Saves the World | NBC | 2013–2014 | 1 | 15 | LGBTQ |
| seaQuest DSV | NBC | 1993–1996 | 3 | 57 | Science fiction |
| Search | NBC | 1972–1973 | 1 | 23 | Science fiction |
| The Search for the Funniest Mom in America | Nickelodeon | 2005–2007 | — | 18 | Comedy |
| Search for Tomorrow | NBC, CBS | 1951–1986 | 35 | 9,130 | Soap opera |
| Search Party | TBS | 2016–2022 | 5 | 50 | Comedy thriller |
| Season 25: Oprah Behind The Scenes | OWN | 2011 | 1 | 31 | Documentary |
| The Second Best Hospital in the GalaxyAnimated series | Prime Video | 2024–on air | — | — | Adult animation |
| Second Chance | ABC | 1977 | — | 95 | Game show |
| Second Chance | Fox | 1987–1988 | 1 | 21 | Sitcom |
| Second Chance | Telemundo, Caracol Televisión | 2005–2006 | — | 155 | Telenovela |
| Second Chance | Fox | 2016 | 1 | 11 | Science fiction |
| Second Chances | CBS | 1993–1994 | 1 | 10 | Romance |
| Second Generation Wayans | BET | 2013 | 1 | 10 | Comedy |
| The Second Half | NBC | 1993–1994 | 1 | 15 | Sitcom |
| The Second Hundred Years | ABC | 1967–1968 | 1 | 26 | Sitcom |
| Second Noah | ABC | 1996–1997 | 2 | 21 | Comedy-drama |
| Second Opinion | PBS | 2004 | 11 | 139 | — |
| Second Time Around | UPN | 2004–2005 | 1 | 13 | Sitcom |
| Second Wives Club | E! | 2017 | 1 | 8 | Reality |
| Seconds From Disaster | National Geographic | 2004–2018 | 6 | 67 | Documentary |
| Secret Agent Man | UPN | 2000 | 1 | 12 | — |
| The Secret Circle | The CW | 2011–2012 | 1 | 22 | Fantasy |
| The Secret Diary of Desmond Pfeiffer | UPN | 1998 | 1 | 9 | Sitcom |
| The Secret Files of the Spy DogsAnimated series | Fox | 1998–1999 | — | 22 | Comedy |
| Secret Girlfriend | Comedy Central | 2009 | 1 | 6 | — |
| Secret History of Comics | AMC | 2017 | 1 | 6 | — |
| Secret Invasion | Disney+ | 2023 | 1 | 6 | Adventure |
| The Secret Life of the American Teenager | Freeform | 2008–2013 | 5 | 121 | Drama |
| Secret Life of Toys | Disney Channel | 1994 | 1 | 13 | Children's |
| The Secret Lives of Men | ABC | 1998 | 1 | 13 | Sitcom |
| The Secret Lives of Mormon Wives | Hulu | 2024–on air | 3 | 29 | Reality |
| The Secret Lives of Waldo Kitty | NBC | 1975 | 1 | 13 | — |
| Secret Millionaires ClubAnimated series | Hub Network | 2011–2017 | 1 | 26 | Children's |
| Secret Mountain Fort AwesomeAnimated series | Cartoon Network | 2011–2012 | 2 | 26 | Fantasy |
| The Secret of Lost Creek | Disney Channel | 1992 | 1 | 5 | Adventure |
| Secret Princes | TLC | 2012–2013 | 2 | 12 | Reality |
| The Secret SaturdaysAnimated series | Cartoon Network | 2008–2010 | 2 | 36 | Adventure |
| Secret Service | NBC | 1992–1993 | 1 | 21 | Action |
| Secret SquirrelAnimated series | NBC, Cartoon Network | 1965 | 2 | 39 | Comedy |
| The Secret Storm | CBS | 1954–1974 | — | 5,195 | Soap opera |
| Secret Talents of the Stars | CBS | 2008 | 1 | 1 | Reality |
| The Secret World of Alex Mack | Nickelodeon | 1994–1998 | 4 | 78 | Science fiction |
| Secrets and Lies | ABC | 2015–2016 | 2 | 20 | Detective |
| Secrets and Wives | Bravo | 2015 | 1 | 8 | Reality |
| Secrets of a Restaurant Chef | Food Network | 2008–2021 | 9 | 119 | Cooking show |
| Secrets of a Small Town | ABC | 2006 | — | 1 | — |
| Secrets of Aspen | VH1 | 2010 | 1 | 8 | Reality |
| The Secrets of Isis | CBS | 1975–1976 | 2 | 22 | Fantasy |
| Secrets of Midland Heights | CBS | 1980–1981 | 1 | 10 | Soap opera |
| Secrets of Sulphur Springs | Disney Channel | 2021–2023 | 3 | 27 | Drama |
| Secrets of the Chippendales Murders | A&E | 2022 | 1 | 4 | True crime |
| Secrets of the Cryptkeeper's Haunted House | CBS | 1996–1997 | — | — | Game show |
| Secrets of the Dead | PBS | 2000 | 13 | 64 | Documentary |
| Secrets of the Zoo: Down Under | National Geographic | 2020–2024 | 4 | — | Documentary |
| Sed de venganza | Telemundo | 2024–2025 | 1 | 83 | Telenovela |
| Seducing Cindy | Fox Reality Channel | 2010 | — | — | Reality |
| See | Apple TV | 2019–2022 | 3 | 24 | Science fiction |
| See Dad Run | Nickelodeon, Nick at Nite | 2012–2015 | 3 | 50 | Sitcom |
| See It NowNews program | CBS | 1951–1958 | — | — | Documentary |
| SeeMore's Playhouse | PBS Kids | 2006–2012 | 2 | 30 | — |
| Seinfeld | NBC | 1989–1998 | 9 | 180 | Sitcom |
| Selena + Chef | HBO Max | 2020–2022 | 4 | 40 | Cooking show |
| Selena's Secret | TNT | 2018 | 1 | 13 | Biographical |
| Selena: The Series | Netflix | 2020–2021 | 2 | 18 | Biographical |
| Self MadeMiniseries | Netflix | 2020 | 1 | 4 | Biographical |
| Selfie | Hulu, ABC | 2014 | 1 | 13 | Sitcom |
| Sell This House | A&E | 2003–2011 | 9 | 170 | — |
| Selling the OC | Netflix | 2022–on air | — | — | Reality |
| Semi-Tough | ABC | 1980 | 1 | 5 | Sitcom |
| Señora tentación | Telemundo | 1994 | — | 60 | Telenovela |
| Sense8Web series | Netflix | 2015–2018 | 2 | 24 | LGBTQ |
| The Sentinel | UPN | 1996–1999 | 4 | 65 | Science fiction |
| Sequestered | Crackle | 2014 | 1 | 12 | Drama |
| Sergeant Preston of the Yukon | CBS | 1955–1958 | 3 | 78 | Western |
| A Series of Unfortunate Events | Netflix | 2017–2019 | 3 | 25 | Black comedy |
| Seriously Funny Kids | Lifetime | 2011 | 1 | 20 | Comedy |
| The Serpent Queen | Starz | 2022–2024 | 2 | 16 | Biographical |
| Serpico | NBC | 1976–1977 | 1 | 15 | Drama |
| Servant | Apple TV | 2019–2023 | 4 | 40 | Thriller |
| Sesame English | NHK Educational TV | 2001–2004 | — | — | — |
| Sesame Street | HBO | 1969 | 56 | 4,744 | Educational |
| Set for Life | ABC | 2007 | 1 | 7 | Game show |
| Seth MacFarlane's Cavalcade of Cartoon ComedyAnimated web series | YouTube | 2008–2009 | 1 | 50 | Comedy |
| Seven Brides for Seven Brothers | CBS | 1982–1983 | 1 | 22 | Drama |
| Seven Days | UPN | 1998–2001 | 3 | 66 | Science fiction |
| Seven Keys | KTLA | 1960–1965 | 5 | — | Game show |
| Seven Little Johnstons | TLC | 2015 | 13 | 113 | Reality |
| Seven Seconds | Netflix | 2018 | 1 | 10 | Crime |
| Seventh AvenueMiniseries | NBC | 1977 | — | 6 | — |
| The Seventies | CNN | 2015 | 1 | 8 | Documentary |
| Severance | Apple TV | 2022–on air | 2 | 19 | Mystery |
| Sex&Drugs&Rock&Roll | FX | 2015–2016 | 2 | 20 | Comedy |
| Sex and the City | HBO | 1998–2004 | 6 | 94 | Romantic comedy |
| Sex Box | We TV | 2015 | 1 | 1 | — |
| Sex Change HospitalMiniseries | More4 | 2007 | 1 | 6 | LGBTQ |
| Sex, Explained | Netflix | 2020 | 1 | 5 | Documentary |
| Sex Games: Vegas | Cinemax | 2005–2006 | 2 | 26 | — |
| Sex in Public | TLC | 2015 | 1 | 6 | Reality |
| Sex/Life | Netflix | 2021–2023 | 2 | 14 | Comedy-drama |
| The Sex Lives of College Girls | HBO Max | 2021–on air | 3 | 20 | Comedy-drama |
| Sex, Love & Secrets | UPN | 2005 | 1 | 10 | — |
| Sex Rehab with Dr. Drew | VH1 | 2009 | 1 | 8 | Reality |
| Sex Sent Me to the ER | TLC | 2013–2016 | 2 | 39 | Reality |
| Sex: The Revolution | VH1, Sundance TV | 2008 | 1 | 4 | Documentary |
| Sex with Brody | E! | 2015 | 1 | 4 | — |
| Sextuplets Take New York | TLC | 2010 | 1 | 8 | Reality |
| Shades of Blue | NBC | 2016–2018 | 3 | 36 | Thriller |
| Shades of L.A. | Syndication | 1990–1991 | 1 | 20 | Detective |
| Shadow and Bone | Netflix | 2021–2023 | 2 | 16 | Fantasy |
| Shadow Chasers | ABC | 1985–1986 | 1 | 13 | Mystery |
| Shadow of the Cloak | DuMont | 1951–1952 | — | 36 | — |
| Shadow of the Elves | Syndication, Super RTL | 2004 | 1 | 26 | Fantasy |
| Shadowhunters | Freeform | 2016–2019 | 3 | 55 | Youth |
| Shaft | CBS | 1973–1974 | 1 | 7 | Crime |
| Shaggy & Scooby-Doo Get a Clue!Animated series | The CW, Kids' WB | 2006–2008 | 2 | 26 | Comedy |
| Shahs of Sunset | Bravo | 2012–2021 | 5 | 51 | Reality |
| Shake It Up | Disney Channel | 2010–2013 | 3 | 75 | Teen sitcom |
| Shake, Rattle and Roll: An American Love StoryMiniseries | CBS | 1999 | — | 2 | — |
| Shaky Ground | Fox | 1992–1993 | 1 | 17 | Sitcom |
| Shameless | Showtime | 2011–2021 | 11 | 134 | Comedy-drama |
| Shane | ABC | 1966 | 1 | 17 | Western |
| Shanna's ShowAnimated series | Playhouse Disney | 2004–2010 | 1 | 14 | Children's |
| The Shannara Chronicles | MTV, Spike TV | 2016–2017 | 2 | 20 | Post-apocalyptic |
| Shannon | Syndication | 1961–1962 | 1 | 36 | Crime |
| Shannon | CBS | 1981–1982 | 1 | 9 | — |
| Shannon's Deal | NBC | 1990–1991 | 2 | 16 | — |
| Shantaram | Apple TV | 2022 | — | 12 | — |
| Shaping Up | ABC | 1984 | 1 | 5 | Sitcom |
| Shaq's Big Challenge | ABC | 2007 | — | 6 | Reality |
| Shaq Vs. | ABC | 2009–2010 | 2 | 10 | Reality |
| Shaquille | ESPN | 2005 | — | — | Reality |
| The Shards | FX | 2026–on air | — | — | Crime |
| Shark | CBS | 2006–2008 | 2 | 38 | Legal drama |
| Shark Tank | ABC | 2009–2020 | 7 | 124 | Reality |
| SharkdogAnimated series | Netflix | 2021–2023 | 3 | — | Comedy |
| The Sharon Osbourne Show | ITV1 | 2006 | 1 | 39 | — |
| Sharp ObjectsMiniseries | HBO | 2018 | 1 | 8 | Thriller |
| Shasta McNasty | UPN | 1999–2000 | 1 | 22 | Sitcom |
| Shaunie's Home Court | VH1 | 2016–2018 | 2 | 12 | Reality |
| Shazam! | CBS | 1974–1977 | 3 | 28 | Science fiction |
| ShazzanAnimated series | CBS | 1967–1969 | 2 | 36 | Fantasy |
| She-Hulk: Attorney at Law | Disney+ | 2022 | 1 | 9 | Action |
| She-RaAnimated series | Syndication | 1985–1986 | 5 | 93 | Comedy |
| She-Ra and the Princesses of PowerAnimated series | Netflix | 2018–2020 | 5 | 52 | Fantasy |
| She's Got Game | VH1 | 2015 | 1 | 8 | Reality |
| She's Got the Look | TV Land | 2008–2010 | 3 | 21 | Reality |
| She's Gotta Have It | Netflix | 2017–2019 | 1 | 10 | LGBTQ |
| She's Living for This | HereTV | 2012 | 1 | 6 | Lgbtq-related |
| She's the Sheriff | Syndication | 1987–1989 | 2 | 44 | Sitcom |
| She Spies | NBC | 2002–2004 | 2 | 40 | Action |
| She TV | ABC | 1994 | 1 | 6 | Sketch comedy |
| She-Wolf of London | Syndication | 1990–1991 | 2 | 20 | Werewolf |
| Shear Genius | Bravo | 2007–2010 | 3 | 29 | Reality |
| Shedding for the Wedding | The CW | 2011 | 1 | 8 | Reality |
| Sheena | Syndication | 2000 | 2 | 35 | Fantasy |
| Sheep in the Big CityAnimated series | Cartoon Network | 2000–2002 | 2 | 26 | Alternative comedy |
| Shell Game | CBS | 1987 | 1 | 6 | Comedy-drama |
| Shenanigans | ABC | 1964–1965 | — | 39 | Game show |
| Sheriff Callie's Wild WestAnimated series | Disney Channel | 2013–2017 | 2 | 45 | Comedy |
| Sheriff Country | CBS | 2025–on air | 2 | 20 | Drama |
| Sheriff of Cochise | Syndication | 1956–1960 | 4 | 156 | Western |
| Sherlock & Daughter | The CW | 2025–on air | 1 | 8 | Historical drama |
| Sherlock Holmes | Syndication | 1954–1955 | 1 | 39 | Detective |
| Sherlock Holmes in the 22nd CenturyAnimated series | Fox Kids | 1999–2001 | 2 | 26 | Adventure |
| Sherri | Lifetime | 2009 | 1 | 13 | Sitcom |
| SherwoodAnimated series | YouTube Premium | 2019–on air | 1 | 10 | Science fiction |
| SheZowAnimated series | Network 10 | 2012–2013 | 1 | 26 | Children's |
| The Shield | FX | 2002–2008 | 7 | 88 | Drama |
| Shifting Gears | ABC | 2025–on air | 2 | 23 | Sitcom |
| Shimmer and ShineAnimated series | Nick Jr. Channel, Nickelodeon | 2015–2020 | 4 | 86 | Children's |
| Shin SonicWeb series | | 2024–on air | 1 | 7 | Kaiju |
| Shindig! | ABC | 1964–1966 | 2 | 86 | Variety show |
| The ShiningMiniseries | ABC | 1997 | 1 | 3 | Fantasy |
| Shining Time Station | PBS | 1989–1993 | 3 | 75 | Anthology |
| Shining Vale | Starz | 2022–on air | 1 | 8 | — |
| Shipmates | Syndication | 2001–2003 | 2 | — | Reality |
| Shipping Wars | A&E | 2012–2015 | 7 | 93 | Documentary |
| Shirley | NBC | 1979–1980 | 1 | 13 | Comedy-drama |
| Shirley Temple's Storybook | NBC | 1958–1961 | 2 | 41 | Fantasy |
| Shirt TalesAnimated series | NBC | 1982–1983 | 2 | 23 | — |
| Shirts & Skins | Logo TV | 2008 | 1 | 6 | LGBTQ |
| Shivaree | Syndication | 1965–1966 | 2 | 70 | — |
| The Shnookums and Meat Funny Cartoon ShowAnimated series | Syndication | 1995 | 1 | 13 | Comedy |
| ShōgunMiniseries | NBC | 1980 | — | 5 | Jidaigeki |
| Shōgun | Hulu, FX | 2024–on air | 1 | 10 | Adventure |
| Shoot for the Stars | NBC | 1977 | — | — | Game show |
| Shooter | USA Network | 2016–2018 | 3 | 31 | Drama |
| Shooting Sizemore | VH1 | 2007 | 1 | 6 | Reality |
| Shootout | AMC | 2003–2008 | 5 | 192 | — |
| Shop 'til You Drop | Lifetime, Ion Television | 1991–2005 | 10 | 980 | Game show |
| Shopping Spree | | 1996–1998 | 2 | 124 | Game show |
| Short Circuitz | MTV | 2007 | — | 8 | — |
| Short Ribbs | KDOC-TV | 1989 | 1 | 13 | Sketch comedy |
| Shorties Watchin' ShortiesAnimated series | Comedy Central | 2004 | — | 13 | Comedy |
| Shorty McShorts' Shorts | Disney Channel, Toon Disney | 2006–2007 | 2 | 13 | Anthology |
| A Shot at Love II with Tila Tequila | MTV | 2008 | 2 | 12 | Reality |
| A Shot at Love with Tila Tequila | MTV | 2007 | 2 | 24 | Reality |
| Shot in the Dark | Netflix | 2017 | 1 | 8 | — |
| Shotgun Slade | Syndication | 1959–1961 | 2 | 78 | Western |
| Shots Fired | Fox | 2017 | 1 | 10 | Drama |
| Show Me a HeroMiniseries | HBO | 2015 | 1 | 6 | Drama |
| The Show with Vinny | MTV | 2013 | 1 | 11 | Reality |
| The Showbiz Show with David Spade | Comedy Central | 2005–2007 | 3 | 39 | — |
| Showbiz Tonight | HLN | 2005–2014 | — | — | Entertainment |
| Showdog Moms & Dads | Bravo | 2005 | 1 | 8 | Reality |
| Shower of Stars | CBS | 1954–1958 | 4 | 32 | Entertainment |
| Showtime at the Apollo | Fox, Syndication | 1987–2008 | 21 | 1,093 | — |
| Shrill | Hulu | 2019–on air | 3 | 22 | LGBTQ |
| The Shrink Next Door | Apple TV | 2021 | — | 8 | — |
| Shrinking | Apple TV | 2023–on air | 3 | 33 | Comedy-drama |
| Shuffle | Freeform | 1994 | 1 | 70 | — |
| Shut Eye | Hulu | 2016–2017 | 2 | 20 | Drama |
| Siberia | NBC | 2013 | 1 | 11 | Drama |
| Siberian Cut | Discovery Channel | 2014 | — | 9 | Reality |
| Sibs | ABC | 1991–1992 | 1 | 22 | Sitcom |
| Sid The Science KidAnimated series | PBS, PBS Kids | 2008–2013 | 2 | 54 | Children's |
| Side Hustle | Nickelodeon | 2020–2022 | 2 | 46 | Comedy |
| Side Order of Life | Lifetime | 2007 | 1 | 13 | — |
| Sidekicks | ABC, Disney Channel | 1986–1987 | 1 | 23 | Action |
| Siegfried & Roy: Masters of the ImpossibleAnimated series | Fox Kids | 1996 | 1 | 4 | Adventure |
| Sierra | NBC | 1974 | 1 | 12 | — |
| Siesta Key | MTV | 2017 | 4 | 78 | Reality |
| The Sifl and Olly Show | MTV | 1997–1999 | 3 | — | Comedy |
| Sightings | Syfy, Fox | 1992–1997 | 5 | 111 | News |
| Sigmund and the Sea Monsters | NBC | 1973–1975 | 2 | 29 | — |
| Signed, Sealed, Delivered | Hallmark Channel | 2013–2014 | 1 | 10 | Comedy-drama |
| Significant Mother | The CW | 2015 | 1 | 9 | Comedy |
| Significant Others | Fox | 1998 | 1 | 6 | Drama |
| Significant Others | Bravo | 2004 | 2 | 12 | Sitcom |
| The Signing | Netflix | 2023–on air | 1 | 8 | Singing talent show |
| Signing Time! | PBS | 2002–2008 | 2 | 26 | Children's |
| The Silent Force | ABC | 1970–1971 | 1 | 15 | — |
| Silent Library | MTV | 2009–2011 | 4 | 92 | Game show |
| The Silent Service | Syndication | 1957–1958 | 2 | 78 | Anthology |
| Silicon Valley | HBO | 2014–2019 | 6 | 53 | Comedy |
| Silk Stalkings | CBS, USA Network | 1991–1999 | 8 | 176 | Crime |
| Silo | Apple TV | 2023–on air | 4 | 30 | Dystopian |
| Silvana sin lana | Telemundo | 2016–2017 | 1 | 121 | Telenovela |
| Silver Spoons | NBC, Syndication | 1982–1987 | 5 | 116 | Sitcom |
| Silver SurferAnimated series | Fox | 1998 | 1 | 13 | Science fiction |
| SilverhawksAnimated series | Syndication | 1986 | 1 | 65 | Science fiction |
| Simon | The WB | 1995–1996 | 1 | 21 | Sitcom |
| Simon & Simon | CBS | 1981–1989 | 8 | 156 | Detective |
| The Simple Life | CBS | 1998 | 1 | 7 | Sitcom |
| The Simple Life | Fox, E! | 2003–2007 | 5 | 55 | Reality |
| Simply Beautiful | Z Living, InTheBoxTV | 2007 | 2 | 52 | Reality |
| Simply Laura | Cooking Channel | 2014–2016 | 2 | 14 | — |
| Simply Ming | PBS, WGBH-TV | 2003 | 14 | 366 | Cooking show |
| The SimpsonsAnimated series | Fox | 1989 | 38 | 813 | Satire |
| Sin City Diaries | Cinemax | 2007 | 1 | 13 | — |
| Sin City Rules | TLC | 2012–2013 | 1 | 8 | Reality |
| Sin City Saints | Yahoo! Screen | 2015 | 1 | 8 | Sitcom |
| Sin senos sí hay paraíso | Telemundo | 2016–2018 | 4 | 322 | Police drama |
| Sinbad Jr. and His Magic BeltAnimated series | Syndication | 1965–1966 | 1 | 102 | — |
| The Sinbad Show | Fox | 1993–1994 | 1 | 24 | Sitcom |
| Sinful Sweets | Cooking Channel | 2015 | 1 | 6 | Food reality |
| Sing It!Web series | YouTube Premium | 2016 | 1 | 10 | Sitcom |
| Sing Me a Story with Belle | Syndication | 1995–1997 | 4 | 65 | — |
| The Sing-Off | NBC, SBS 6 | 2009–2014 | 5 | 28 | Talent show |
| Sing On! | Netflix | 2020–on air | — | — | Game show |
| Singer & Sons | NBC | 1990 | 1 | 4 | Sitcom |
| The Singing Bee | CMT, NBC | 2007–2012 | 5 | — | Game show |
| Single Drunk Female | Freeform | 2022–2023 | 2 | 20 | Comedy-drama |
| The Single Guy | NBC | 1995–1997 | 2 | 44 | Sitcom |
| Single Ladies | VH1 | 2011–2015 | 4 | 42 | Comedy-drama |
| Single Parents | ABC | 2018–2020 | 2 | 28 | Comedy |
| Singled Out | MTV | 1995–1998 | — | — | Game show |
| The Sinner | USA Network | 2017–2021 | 4 | 32 | LGBTQ |
| SinsMiniseries | CBS | 1986 | — | 3 | — |
| Sins and Secrets | Investigation Discovery | 2011–2013 | 4 | 45 | Documentary |
| Sins of the City | USA Network | 1998 | 1 | 13 | Crime |
| Siren | Freeform | 2018–2020 | 3 | 36 | Fantasy |
| Sirens | ABC | 1993–1995 | 2 | 35 | — |
| Sirens | USA Network | 2014–2015 | 2 | 23 | LGBTQ |
| SirensMiniseries | Netflix | 2025 | 1 | 5 | Black comedy |
| Sirota's Court | NBC | 1976–1977 | 1 | 13 | Sitcom |
| Sistas | BET | 2019–on air | 7 | 146 | Comedy-drama |
| Sister Kate | NBC | 1989–1990 | 1 | 19 | Sitcom |
| Sister, Sister | The WB, ABC | 1994–1999 | 6 | 119 | Teen sitcom |
| Sister Wives | TLC | 2010 | 4 | 73 | Reality |
| The Sisterhood | TLC | 2013 | 1 | 8 | Reality |
| The Sisterhood: Becoming Nuns | Lifetime | 2014 | 1 | 6 | Reality |
| Sisterhood of Hip Hop | Oxygen | 2014–2016 | 2 | 16 | Reality |
| Sisters | NBC | 1991–1996 | 6 | 127 | Soap opera |
| Sit Down Comedy with David Steinberg | TV Land | 2005–2007 | 2 | 12 | — |
| Sit Down, Shut UpAnimated series | Fox | 2009 | 1 | 13 | Sitcom |
| Sitting DucksAnimated series | Cartoon Network | 2001–2004 | 2 | 26 | Comedy |
| The Situation Room | CNN | 2000 | — | — | Opinion journalism |
| Six | History | 2017–2018 | 2 | 18 | Action |
| Six Degrees | ABC | 2006–2007 | 1 | 13 | Drama |
| Six Feet Under | HBO | 2001–2005 | 5 | 63 | Black comedy |
| The Six Million Dollar Man | ABC | 1974–1978 | 5 | 99 | Science fiction |
| The Sixth Sense | ABC | 1972 | 2 | 26 | Thriller |
| The SixtiesMiniseries | CNN | 2014 | 1 | 10 | Documentary |
| Sk8 | NBC | 2001–2002 | 1 | 13 | Teen drama |
| SK8-TV | Nickelodeon | 1990 | — | 13 | — |
| Skag | NBC | 1980 | 1 | 6 | — |
| The Skatebirds | CBS | 1977–1978 | 1 | 16 | Live action & animation |
| Skating with Celebrities | Fox | 2006 | 1 | 7 | Reality |
| Skating with the Stars | ABC | 2010 | 1 | 6 | — |
| Skeleton WarriorsAnimated series | CBS | 1995 | 1 | 13 | Fantasy |
| Skillsville | PBS Kids | 2025–2026 | — | — | — |
| Skin | Fox | 2003–2005 | 1 | 8 | Drama |
| Skin Wars | Game Show Network | 2014–2016 | 3 | 30 | Reality |
| Skins | MTV | 2011 | 1 | 10 | Comedy |
| Skip, Rachel, Robert, Lil, Keyshawn and Josina: Undisputed | Fox Sports 1 | 2016 | 3 | — | Talk show |
| Skull IslandAnimated series | | 2023–on air | 1 | 8 | Adventure |
| Sky Commanders | Syndication | 1987 | — | 13 | — |
| Sky King | NBC | 1951–1959 | 4 | 72 | — |
| Skylanders AcademyAnimated series | Netflix | 2016–2018 | 3 | 38 | Action |
| Skysurfer Strike Force | Syndication | 1995–1996 | — | 26 | — |
| SkyWeek | PBS | 2011–2014 | 4 | 52 | — |
| Slacker CatsAnimated series | Freeform | 2007 | 2 | 12 | — |
| Slangman's World | | 2007–2008 | 2 | 11 | Children's |
| The SlapMiniseries | NBC | 2015 | 1 | 8 | Drama |
| The Slap Maxwell Story | ABC | 1987–1988 | 1 | 22 | Sitcom |
| Slattery's People | CBS | 1964–1965 | 2 | 36 | Drama |
| Sledge Hammer! | ABC | 1986–1988 | 2 | 41 | Comedy |
| Slednecks | MTV | 2014 | 1 | 19 | — |
| Sleeper Cell | Showtime | 2005–2006 | 2 | 18 | Drama |
| Sleepwalkers | NBC | 1997–1998 | 1 | 9 | Science fiction |
| Sleepy Hollow | Fox | 2013–2017 | 4 | 62 | Drama |
| Sliced | History | 2010 | 1 | 17 | Documentary |
| Sliders | Fox | 1995–2000 | 5 | 88 | Science fiction |
| Slime Time Live | Nickelodeon | 2000–2004 | 8 | 13 | Game show |
| Slimer! and the Real GhostbustersAnimated series | ABC | 1986–1991 | 7 | 140 | Comedy |
| Slippin' JimmyAnimated series | AMC+ | 2022–on air | 1 | 6 | Comedy |
| Slow Horses | Apple TV | 2022–on air | 6 | 34 | Espionage |
| Small & Frye | CBS | 1983 | 1 | 6 | Fantasy |
| Small Fry Club | DuMont | 1947–1951 | 4 | — | Children's |
| A Small Light | National Geographic, Disney+ | 2023 | — | 8 | Biographical drama |
| Small Potatoes | CBeebies | 2011 | 1 | 27 | — |
| Small Talk | Freeform | 1996–1997 | 1 | 65 | Game show |
| Small Town Security | AMC | 2012–2014 | 3 | 24 | Reality |
| Small Wonder | Syndication | 1985–1989 | 4 | 96 | Sitcom |
| Smallville | The WB | 2001–2011 | 10 | 217 | Drama |
| Smart Guy | The WB | 1997–1999 | 3 | 51 | Sitcom |
| Smash | NBC | 2012–2013 | 2 | 32 | Drama |
| Smash Lab | Discovery Channel | 2007–2009 | 2 | 20 | Reality |
| SMILF | Showtime | 2017–2019 | 2 | 18 | Comedy |
| Smiling FriendsAnimated series | Adult Swim | 2022–2026 | 3 | 27 | Animated sitcom |
| Smith | CBS | 2006 | 1 | 7 | Drama |
| The Smith Family | ABC | 1971–1972 | 2 | 39 | Comedy-drama |
| Smoke | Apple TV | 2025–on air | — | — | Drama |
| The Smokey Bear ShowAnimated series | ABC | 1969 | 1 | 17 | — |
| The Smothers Brothers Comedy Hour | CBS | 1967–1969 | 3 | 72 | Variety show |
| The Smothers Brothers Show | CBS | 1965–1966 | 1 | 32 | Sitcom |
| The SmurfsAnimated series | NBC | 1981–1989 | 9 | 256 | Fantasy |
| Snap Judgment | NBC | 1967–1969 | 3 | 308 | — |
| Snapped | Oxygen | 2004 | 22 | — | Documentary |
| Snapped: Killer Couples | Oxygen | 2013 | 9 | 90 | — |
| Snatch | Crackle | 2017–2018 | 2 | 20 | Drama |
| Sneakerheads | Netflix | 2020 | 1 | 6 | Comedy |
| Sneaky Pete | Prime Video | 2015–2019 | 3 | 30 | Drama |
| Sniz & Fondue | Nickelodeon | 1996–1998 | — | 24 | — |
| Snooki & Jwoww | MTV | 2012–2015 | 3 | 48 | Reality |
| Snoop Dogg's Father Hood | E! | 2007–2009 | 2 | 18 | Reality |
| The Snoop Sisters | NBC | 1973–1974 | 1 | 5 | Comedy |
| Snooper and BlabberAnimated series | | 1959–1961 | 3 | 45 | Crossover |
| Snoops | CBS | 1989–1990 | 1 | 13 | Comedy-drama |
| Snoops | ABC | 1999 | 1 | 13 | Comedy-drama |
| SnorksAnimated series | NBC | 1984–1989 | 4 | 68 | Fantasy |
| Snowfall | FX | 2017–2023 | 6 | 60 | Drama |
| Snowpiercer | TNT | 2020–2024 | 4 | 40 | Post-apocalyptic |
| So Cosmo | E! | 2017 | 1 | 8 | — |
| So Help Me Todd | CBS | 2022–2024 | 2 | 31 | — |
| So Little Time | Freeform | 2001–2002 | 1 | 26 | Teen sitcom |
| So NoTORIous | VH1 | 2006 | 1 | 10 | Sitcom |
| So Random! | Disney Channel | 2011–2012 | 1 | 26 | Children's |
| So Weird | Disney Channel | 1999–2001 | 3 | 65 | Children's |
| So You Think You Can Dance | Fox | 2005–2022 | 17 | 308 | Talent show |
| Soap | ABC | 1977–1981 | 4 | 91 | Comedy |
| Social Distance | Netflix | 2020 | — | — | Anthology |
| Social Fabric | Red Bull TV | 2017 | 1 | 12 | Documentary |
| The Society | Netflix | 2019 | 1 | 10 | Mystery |
| SOF: Special Ops Force | Syndication | 1997–1999 | 2 | 37 | — |
| Sofía dame tiempo | Telemundo | 2003 | — | 130 | Telenovela |
| Sofia the FirstAnimated series | Disney Channel, Disney Jr. | 2012–2018 | 4 | 109 | Crossover |
| Solar OppositesAnimated series | Hulu | 2020–2025 | 6 | 63 | Animated sitcom |
| Sold! | History | 2012 | 1 | 10 | Reality |
| Soldiers of Fortune | Syndication | 1955–1957 | 2 | 52 | — |
| Solid Gold Countdown | Syndication | 1980–1988 | 8 | 332 | Music chart |
| Solitary | Fox Reality Channel | 2006–2010 | 4 | 36 | Reality |
| SolomonMiniseries | Rai 1 | 1997 | — | 2 | Drama |
| Solved | Investigation Discovery | 2008–2010 | 3 | 32 | Documentary |
| Solving History with Olly Steeds | Discovery Channel | 2010 | 1 | 8 | Documentary |
| Some Assembly Required | Discovery Channel | 2007–2008 | 2 | 15 | — |
| Some of My Best Friends | CBS | 2001 | 1 | 7 | Sitcom |
| Somebody Feed Phil | Netflix | 2018–on air | 3 | 17 | Travel documentary |
| Somebody's Gotta Do It | CNN | 2014–2018 | 3 | 24 | Reality |
| Somebody Somewhere | HBO | 2022–2024 | 3 | 21 | Comedy-drama |
| Someone Like Me | NBC | 1994 | 1 | 6 | Sitcom |
| Somerset | NBC | 1970–1976 | 6 | 1,710 | Soap opera |
| Somerset Maugham TV Theatre | CBS | 1950–1951 | 3 | 47 | — |
| Something Borrowed Something New | TLC | 2013–2014 | 3 | 54 | Reality |
| Something Is Out ThereMiniseries | NBC | 1988 | 1 | 9 | Science fiction |
| Something So Right | NBC, ABC | 1996–1998 | 2 | 37 | Sitcom |
| Something Very Bad Is Going to Happen | Netflix | 2026–on air | — | — | Horror |
| Something Wilder | NBC | 1994–1995 | 1 | 18 | Sitcom |
| Somewhere Between | ABC | 2017 | 1 | 10 | Thriller |
| Somos tú y yo, un nuevo día | Boomerang, Venevisión | 2009 | 1 | 50 | Comedy-drama |
| The Son | AMC | 2017–2019 | 2 | 20 | Drama |
| Son of the Beach | FX | 2000–2002 | 3 | 43 | LGBTQ |
| Son of Zorn | Fox | 2016–2017 | 1 | 13 | Sitcom |
| Soñar no Cuesta Nada | Univision | 2005–2006 | — | 191 | Telenovela |
| Song Exploder | Netflix | 2020 | — | — | Documentary |
| Sonic BoomAnimated series | Cartoon Network, Boomerang | 2014–2017 | 2 | 104 | Adventure |
| Sonic PrimeAnimated series | Netflix | 2022–2024 | 3 | 23 | Fantasy |
| Sonic the HedgehogAnimated series | ABC | 1993–1994 | 2 | 26 | Fantasy |
| The Sonny & Cher Comedy Hour | CBS | 1971–1974 | 4 | 63 | Comedy |
| The Sonny Comedy Revue | ABC | 1974 | 1 | 13 | — |
| Sonny Spoon | NBC | 1988 | 2 | 15 | Detective |
| Sonny with a Chance | Disney Channel | 2009–2011 | 2 | 46 | Teen sitcom |
| Sons and Daughters | CBS | 1974 | 1 | 9 | — |
| Sons and Daughters | CBS | 1991 | 1 | 13 | Comedy-drama |
| Sons & Daughters | ABC | 2006 | 1 | 11 | Sitcom |
| Sons of Anarchy | FX | 2008–2014 | 7 | 92 | Crime |
| Sons of Guns | Discovery Channel | 2011–2014 | 5 | 65 | Reality |
| Sons of Hollywood | A&E | 2007 | 1 | 13 | Reality |
| Sons of LibertyMiniseries | History | 2015 | 1 | 3 | Historical |
| The Sons of Sam: A Descent into DarknessMiniseries | Netflix | 2021 | 1 | 4 | Crime |
| Sons of Thunder | CBS | 1999 | 1 | 6 | Detective |
| Sons of Tucson | Fox | 2010 | 1 | 13 | Sitcom |
| The Sophisticated GentsMiniseries | NBC | 1981 | — | — | — |
| The Sopranos | HBO | 1999–2007 | 6 | 86 | Drama |
| Sordid Lives: The Series | Logo TV | 2008 | 1 | 12 | LGBTQ |
| Sorority ForeverWeb series | | 2008 | — | 40 | — |
| Sorority Life | MTV | 2002–2003 | — | 28 | College life |
| Soul Food | Showtime | 2000–2004 | 5 | 74 | — |
| Soul Man | ABC | 1997–1998 | 2 | 25 | Sitcom |
| The Soul Man | TV Land | 2012–2016 | 5 | 54 | Sitcom |
| Soul Quest OverdriveAnimated series | Adult Swim | 2011 | 1 | 4 | Adult animation |
| Soul Train | Syndication, WCIU-TV | 1971–2006 | — | 1,117 | Variety show |
| Soulmates | AMC | 2020 | 1 | 6 | Anthology |
| The Sound of Jazz | CBS | 1957 | — | 1 | Music |
| Soundtrack | Netflix | 2019 | 1 | 10 | Drama |
| The Soup | E! | 2004–2015 | 12 | 618 | Comedy |
| The Soup Investigates | E! | 2013 | 1 | 7 | — |
| The Source with Kaitlan Collins | CNN, CNN Max | 2022 | — | — | News |
| South Beach | NBC | 1993 | 1 | 7 | — |
| South Beach | UPN | 2006 | 1 | 8 | — |
| South Beach Tow | TruTV | 2011–2014 | 4 | 86 | Reality |
| South Central | Fox | 1994 | 1 | 10 | Comedy-drama |
| South Dakota Adventure | South Dakota Public Broadcasting | 1980–1984 | 4 | 32 | — |
| South of Hell | We TV | 2015 | 1 | 8 | Thriller |
| South of Nowhere | Noggin | 2005–2008 | 3 | 40 | LGBTQ |
| South of Sunset | CBS | 1993 | — | — | — |
| South ParkAnimated series | Comedy Central, Canal+ Polska | 1997 | 29 | 344 | Surreal humour |
| South Side | Comedy Central, Cinemax | 2019–2022 | — | — | Sitcom |
| Southern Belles: Louisville | Soapnet | 2009 | 1 | 11 | Reality |
| Southern Charm | Bravo | 2014 | 3 | 23 | Reality |
| Southern Charm Savannah | Bravo | 2017–2018 | — | — | Reality |
| Southie Rules | A&E | 2013 | 1 | 11 | Reality |
| Southland | NBC | 2009–2013 | 5 | 43 | Police procedural |
| Sox Appeal | New England Sports Network | 2007–2008 | 2 | 10 | Reality |
| Space: Above and Beyond | Fox | 1995–1996 | 1 | 24 | Science fiction |
| Space Academy | CBS | 1977–1979 | 1 | 15 | Science fiction |
| Space Cases | Nickelodeon | 1996–1997 | 2 | 27 | Science fiction |
| Space CatsAnimated series | NBC | 1991–1992 | 1 | 13 | Comedy |
| Space Force | Netflix | 2020–2022 | 2 | 17 | Comedy |
| Space GhostAnimated series | CBS | 1966–1967 | 2 | 42 | Science fiction |
| Space Ghost Coast to CoastAnimated series | Adult Swim, Cartoon Network | 1994–2008 | 11 | 113 | Talk show |
| The Space KidettesAnimated series | NBC | 1966–1967 | 1 | 20 | Science fiction |
| Space Patrol | ABC | 1950–1955 | 5 | 1,110 | Science fiction |
| Space Racers | PBS | 2014 | 3 | 26 | — |
| Space Rangers | CBS | 1993 | 1 | 6 | Science fiction |
| Space SentinelsAnimated series | NBC | 1977 | 1 | 13 | Children's |
| Space Stars | NBC | 1981–1982 | — | 11 | — |
| Space StrikersAnimated series | M6 | 1995 | 1 | 26 | Science fiction |
| Spaceballs: The Animated SeriesAnimated series | Super Channel | 2008–2009 | 1 | 13 | Science fiction |
| Spain... on the Road Again | PBS | 2008 | 1 | 13 | — |
| The Spanish Princess | Starz | 2019–on air | — | 16 | Historical |
| Sparks | UPN | 1996–1998 | 2 | 40 | Sitcom |
| Spartacus | Starz | 2010–2013 | 3 | 33 | Action |
| Spartacus: Gods of the ArenaMiniseries | Starz | 2011 | 1 | 6 | Historical drama |
| Spartacus: House of Ashur | Starz | 2025–on air | 1 | 10 | Historical drama |
| Spartan: Ultimate Team Challenge | NBC | 2016–2017 | 2 | 14 | — |
| Speak for Yourself with Cowherd & Whitlock | Fox Sports 1 | 2016 | 1 | — | Talk show |
| Special | Netflix | 2019–2021 | 2 | 16 | LGBTQ |
| Special Agent OsoAnimated series | Disney Channel | 2009–2012 | 2 | 60 | Comedy |
| Special Forces: World's Toughest Test | Fox | 2023–on air | 1 | 10 | — |
| Special Ops: Lioness | Paramount+ | 2023–on air | 3 | 24 | Action |
| Special Ops Mission | American Heroes Channel | 2009 | 1 | 6 | Reality |
| Special Report w/Bret BaierNews program | Fox News | 1998 | — | — | News |
| Special Unit 2 | UPN | 2001–2002 | 2 | 19 | Fantasy |
| The Spectacular Spider-ManAnimated series | The CW | 2008–2009 | 2 | 26 | Science fiction |
| Speechless | ABC | 2016–2019 | 3 | 63 | Sitcom |
| Speed BuggyAnimated series | CBS | 1973 | 1 | 16 | — |
| Speed Racer: The Next GenerationAnimated series | Nicktoons | 2008–2013 | 2 | 52 | Children's |
| Spell-Mageddon | Freeform | 2013 | 1 | 8 | — |
| Spencer | NBC | 1984–1985 | 1 | 13 | Sitcom |
| Spencer's Pilots | CBS | 1976 | 1 | 11 | — |
| Spenser: For Hire | ABC | 1985–1988 | 3 | 66 | Detective |
| Spicy CityAnimated series | HBO | 1997 | 1 | 6 | Cyberpunk |
| Spider-ManAnimated series | ABC | 1967–1970 | 3 | 52 | Action |
| Spider-ManAnimated series | Syndication | 1981–1982 | 1 | 26 | Superhero |
| Spider-ManAnimated series | Fox Kids, Fox | 1994–1998 | 5 | 65 | Children's |
| Spider-Man and His Amazing FriendsAnimated series | NBC | 1981–1983 | 3 | 24 | Superhero |
| Spider-Man Noir | MGM+ | 2026–on air | — | — | Crime |
| Spider-Man: The New Animated SeriesAnimated series | MTV | 2003 | 1 | 13 | Mystery |
| Spider-Man UnlimitedAnimated series | Fox Kids | 1999–2001 | 1 | 13 | Superhero |
| Spider-WomanAnimated series | ABC | 1979–1980 | 1 | 16 | Science fiction |
| The Spiderwick Chronicles | Disney+ | 2024–on air | 1 | 6 | Adventure |
| Spidey and His Amazing FriendsAnimated series | Disney Jr. | 2021–on air | 4 | 64 | Children's |
| Spidey Super Stories | PBS | 1974–1977 | 2 | 28 | — |
| Spies | CBS | 1987 | 1 | 6 | — |
| Spin City | ABC | 1996–2002 | 6 | 145 | Sitcom |
| The Spin Crowd | E! | 2010 | 1 | 8 | Reality |
| Spin-Off | CBS | 1975 | — | 50 | — |
| Spin the Picture | DuMont | 1949–1950 | — | — | Game show |
| Spin the Wheel | Fox | 2019 | — | — | Game show |
| Spinning Out | Netflix | 2020–on air | 1 | 10 | Teen drama |
| Spiral ZoneAnimated series | Syndication | 1987 | 1 | 65 | Science fiction |
| Spirit of Television | Syndication | 1993 | — | 14 | — |
| Spirit Riding FreeAnimated series | Netflix | 2017–2020 | 8 | 52 | — |
| Splash | ABC | 2013 | 1 | 8 | Reality |
| Splash and BubblesAnimated series | PBS, PBS Kids | 2016–2018 | 1 | 40 | Fantasy |
| Splatalot! | YTV | 2011–2013 | 2 | 53 | Reality |
| Split Screen | IFC | 1997–2001 | 4 | 66 | — |
| Split Second | ABC, Syndication | 1986–1987 | — | 1,025 | — |
| Splitting Up Together | ABC | 2018–2019 | 2 | 26 | Comedy |
| The Spoils Before DyingMiniseries | IFC | 2015 | 1 | 6 | Comedy |
| The Spoils of BabylonMiniseries | IFC | 2014 | 1 | 6 | Comedy |
| SpongeBob SquarePantsAnimated series | Nickelodeon, ARB Günəş | 1999 | 16 | 330 | Fantasy |
| Spooksville | Discovery Family | 2013–2014 | 1 | 22 | Action |
| The Spooktacular New Adventures of CasperAnimated series | Fox Kids | 1996–1998 | 4 | 52 | Comedy |
| Sport Billy | NBC | 1979–1981 | 2 | 26 | — |
| Sport Science | ESPN | 2007–2009 | 3 | 24 | Documentary |
| Sports Kids Moms & Dads | Bravo | 2005 | 1 | 8 | Reality |
| Sports Night | ABC | 1998–2000 | 2 | 45 | Comedy-drama |
| The Sports Reporters | Compass Media Networks, ESPN | 1988–2017 | — | — | — |
| Sports Show with Norm Macdonald | Comedy Central | 2011 | 1 | 9 | Comedy |
| SportsCentury | ESPN | 1999–2007 | — | 261 | Documentary |
| Sportsworld | NBC | 1978–1994 | 14 | — | Anthology |
| SPRINT | Netflix | 2024–on air | 2 | 10 | Docudrama |
| Spy Game | ABC | 1997 | 1 | 13 | — |
| Spy Games | Bravo | 2020–on air | 1 | 8 | Reality |
| Spy GrooveAnimated series | MTV | 2000–2002 | 1 | 13 | Adult animation |
| Spy Kids: Mission Critical | Netflix | 2018 | 2 | 20 | Action |
| Spycraft | Netflix | 2021–on air | — | — | — |
| Spyder Games | MTV | 2001 | 1 | 65 | Soap opera |
| Spyders | Nickelodeon, TeenNick | 2020–2022 | 4 | 80 | Sitcom |
| Square One Television | PBS | 1987–1992 | — | 230 | — |
| Square Pegs | CBS | 1982–1983 | 1 | 20 | Comedy |
| Squawk BoxNews program | CNBC | 1995 | — | — | News |
| Squawk on the StreetNews program | CNBC | 2005 | — | — | News |
| SquidbilliesAnimated series | Adult Swim | 2005–2016 | 13 | 110 | Comedy |
| Squiddly DiddlyAnimated series | NBC | 1965 | 2 | 26 | — |
| Squirrel BoyAnimated series | Cartoon Network | 2006–2007 | 2 | 52 | Animated sitcom |
| Squirt TV | MTV | 1994–1996 | — | — | — |
| St. Bear's Dolls Hospital | PBS Kids, NBC | 1998 | — | — | Children's |
| St. Elsewhere | NBC | 1982–1988 | 6 | 137 | Medical drama |
| Stacked | Fox | 2005–2006 | 2 | 19 | Sitcom |
| Stage 7 | CBS | 1955 | 1 | 25 | Anthology |
| Stage a Number | DuMont | 1952–1953 | — | — | — |
| Stagecoach West | ABC | 1960–1961 | 1 | 38 | Western |
| The StaircaseMiniseries | HBO Max | 2022 | — | 8 | Drama |
| Stalked: Someone's Watching | Investigation Discovery | 2011–2014 | 4 | 38 | Documentary |
| Stalker | CBS | 2014–2015 | 1 | 20 | Thriller |
| Stan Against Evil | IFC | 2016–2018 | 3 | 24 | Horror |
| Stan Lee's Superhumans | History | 2010–2014 | 2 | 21 | — |
| The StandMiniseries | ABC | 1994 | — | 4 | Adventure |
| The StandMiniseries | HBO, Paramount+ | 2020–2021 | 1 | 9 | Fantasy |
| Stand By for Crime | ABC | 1949 | 1 | 2 | Crime |
| Stand Up and Cheer | Syndication | 1971–1974 | 3 | 48 | Variety show |
| Standby...Lights! Camera! Action! | Nickelodeon | 1982–1987 | — | — | Documentary |
| Standoff | Fox | 2006–2007 | 1 | 18 | Police drama |
| Standup and Away! with Brian Regan | Netflix | 2018–on air | — | — | Comedy |
| The Standups | Netflix | 2017 | 2 | 6 | Comedy |
| Stankervision | MTV2 | 2005–2006 | — | — | — |
| StanleyAnimated series | Playhouse Disney, Starz | 2001–2004 | 3 | 65 | — |
| Star | Fox | 2016–2019 | 3 | 48 | Drama |
| The Star and the Story | PBS, Syndication | 1955–1956 | 2 | 39 | — |
| Star-Crossed | The CW | 2014 | 1 | 13 | Science fiction |
| Star Darlings | Disney Channel | 2015 | 1 | 24 | Animation |
| Star Falls | Nickelodeon | 2018 | 1 | 20 | Comedy |
| Star Search | Syndication | 1983–2003 | — | — | Reality |
| Star Tonight | ABC | 1955–1956 | 2 | 80 | Anthology |
| Star Trek | NBC | 1966–1969 | 3 | 79 | Adventure |
| Star TrekAnimated series | NBC | 1973–1974 | 2 | 22 | Comedy |
| Star Trek: Deep Space Nine | Syndication | 1993–1999 | 7 | 176 | Science fiction |
| Star Trek: Discovery | Paramount+, CBS | 2017–2024 | 5 | 65 | Drama |
| Star Trek: Enterprise | UPN | 2001–2005 | 4 | 98 | Military science fiction |
| Star Trek: Lower DecksAnimated series | Paramount+ | 2020–2024 | 5 | 50 | Adult animation |
| Star Trek: Of Gods and MenMiniseries | | 2008 | — | 3 | Dystopian |
| Star Trek: Picard | Paramount+ | 2020–2023 | 3 | 30 | Drama |
| Star Trek: ProdigyAnimated series | Paramount+, Netflix | 2021–2024 | 2 | 40 | Children's |
| Star Trek: Short Treks | Paramount+ | 2018–2020 | 2 | 10 | Science fiction |
| Star Trek: Strange New Worlds | Paramount+ | 2022–on air | 4 | 40 | Drama |
| Star Trek: The Next Generation | Syndication | 1987–1994 | 7 | 178 | Adventure |
| Star Trek: Very Short Treks | YouTube | 2023 | 1 | 5 | Anthology |
| Star Trek: Voyager | UPN | 1995–2001 | 7 | 172 | Adventure |
| Star vs. the Forces of EvilAnimated series | Disney Channel, Disney XD | 2015–2019 | 4 | 77 | Children's |
| Star WarsAnimated series | Cartoon Network | 2003–2005 | 3 | 25 | Fantasy |
| Star WarsAnimated series | Netflix, Cartoon Network | 2008–2020 | 7 | 133 | Fantasy |
| Star WarsAnimated series | Disney+ | 2021–2023 | 2 | 18 | Science fiction |
| Star WarsAnimated series | Disney Channel | 2023–2025 | 1 | 19 | Children's |
| Star Wars | Disney+ | 2024–on air | 1 | 8 | Adventure |
| Star Wars: DroidsAnimated series | ABC | 1985–1986 | 1 | 13 | Children's |
| Star Wars Forces of DestinyAnimated series | Disney Channel | 2017–2018 | 2 | 32 | Science fiction |
| Star Wars: Jedi Temple ChallengeWeb series | Star Wars Kids | 2020 | 1 | 10 | Game show |
| Star Wars: Maul – Shadow LordAnimated series | Disney+ | 2026–on air | — | 10 | Science fiction |
| Star Wars RebelsAnimated series | Disney XD | 2014–2018 | 4 | 75 | Science fiction |
| Star Wars ResistanceAnimated series | Disney XD | 2018–2020 | 2 | 40 | Science fiction |
| Star Wars: The Acolyte | Disney+ | 2024 | 1 | 8 | Drama |
| Star Wars: The Bad BatchAnimated series | Disney+ | 2021–2024 | 3 | 18 | Science fiction |
| Starcade | TBS | 1982–1984 | — | — | — |
| StarcomAnimated series | Syndication | 1987 | 1 | 13 | Science fiction |
| Starface | Game Show Network | 2006 | — | 40 | — |
| Stargate Atlantis | Syfy | 2004–2009 | 5 | 100 | Science fiction |
| Stargate InfinityAnimated series | Fox | 2002–2003 | 1 | 26 | Comedy |
| Stargate SG-1 | Syfy, Showtime | 1997–2007 | 10 | 213 | Adventure |
| Stargate Universe | Syfy | 2009–2011 | 2 | 40 | Drama |
| Stargirl | DC Universe | 2020–2022 | 3 | 39 | Adventure |
| Stark Raving Mad | NBC | 1999–2000 | 1 | 22 | Sitcom |
| Starman | ABC | 1986–1987 | 1 | 22 | Science fiction |
| Stars Earn Stripes | NBC | 2012 | 1 | 8 | Reality |
| Starsky & Hutch | ABC | 1975–1979 | 4 | 93 | Crime |
| Starsky and Hutch on Playboy Island | ABC | 1977 | — | — | Comedy |
| Start-Ups: Silicon Valley | Bravo | 2012 | 1 | 8 | Reality |
| StarTalk | National Geographic | 2015 | 5 | 20 | Talk show |
| The Starter Wife | USA Network | 2007 | 2 | 16 | Drama |
| The Starter Wife | USA Network | 2008 | 1 | 10 | — |
| Starter Wives Confidential | TLC | 2013 | 1 | 3 | Reality |
| Startime | NBC | 1959–1960 | 1 | 33 | Music |
| Starting Over | | 2003–2006 | 3 | 270 | Reality |
| Starting PointNews program | CNN | 2012–2013 | — | — | — |
| StartUp | Crackle | 2016–2018 | 3 | 30 | Drama |
| Startup U | Freeform | 2015 | 1 | 10 | — |
| Starved | FX | 2005 | 1 | 7 | LGBTQ |
| StarveillanceAnimated series | E! | 2007 | 1 | 6 | Comedy |
| Stat | ABC | 1991 | 1 | 6 | Sitcom |
| The State | MTV | 1993–1995 | 4 | 28 | Sketch comedy |
| State of Affairs | NBC | 2014–2015 | 1 | 13 | Drama |
| State of Georgia | Freeform | 2011 | 1 | 12 | Teen sitcom |
| State of Grace | Freeform | 2001–2002 | 2 | 38 | — |
| State of Mind | Lifetime | 2007 | 1 | 8 | Comedy-drama |
| State of the Union | Sundance TV | 2019–on air | 2 | 20 | Comedy-drama |
| State of the Union with Jake Tapper & Dana Bash | CNN | 2009 | — | 323 | News commentary podcast |
| State Trooper | NBC | 1956–1959 | 3 | 104 | Western |
| Static ShockAnimated series | The WB | 2000–2004 | 4 | 52 | Comedy-drama |
| Station 19 | ABC | 2018–2024 | 7 | 105 | Drama |
| Station ElevenMiniseries | HBO Max | 2021–2022 | — | 10 | Post-apocalyptic |
| Station Zero | MTV | 1999 | 1 | 20 | — |
| Stay Here | Netflix | 2018–on air | — | — | Reality |
| Steampunk'd | Game Show Network | 2015 | 1 | 8 | Reality |
| Stella | Comedy Central | 2005 | 1 | 10 | — |
| Step by Step | ABC | 1991–1998 | 7 | 160 | Comedy |
| Step It Up and Dance | Bravo | 2008 | 1 | 10 | Reality |
| Step Up: High Water | YouTube Premium | 2018–2022 | 3 | 30 | — |
| Stephen Hawking's Favorite Places | Curiosity Stream | 2016 | — | 3 | Documentary |
| Sterling Point | Prime Video | 2026–on air | 1 | 8 | Drama |
| Steve | Facebook Watch | 2017 | 2 | 71 | Talk show |
| The Steve Allen Show | NBC | 1956–1964 | 6 | 167 | Variety show |
| Steve Austin's Broken Skull Challenge | CMT | 2014–2017 | 3 | 38 | Reality |
| Steve Canyon | NBC | 1958–1959 | 1 | 34 | — |
| Steve Donovan, Western Marshal | Syndication | 1955–1956 | 1 | 39 | Western |
| Steve Harvey | Syndication | 2012–2017 | 4 | 500 | Talk show |
| Steve Harvey's Big Time Challenge | The WB | 2003–2005 | 2 | — | — |
| Steve Harvey's Funderdome | ABC | 2017 | 1 | 9 | Reality |
| The Steve Harvey Show | The WB | 1996–2002 | 6 | 123 | Sitcom |
| Steve Randall | DuMont | 1952–1953 | — | 14 | — |
| Steven Seagal: Lawman | A&E | 2009–2014 | 3 | 28 | Reality |
| Steven UniverseAnimated series | Cartoon Network | 2013–2019 | 5 | 108 | Science fiction |
| Steven Universe FutureAnimated series | Cartoon Network | 2019–2020 | 1 | 20 | Comedy-drama |
| Stevie and ZoyaAnimated web series | | 1987–1989 | — | — | Action |
| Stevie J & Joseline: Go Hollywood | VH1 | 2016 | 1 | 8 | Reality |
| Stevie TV | VH1 | 2012–2013 | 2 | 14 | Comedy |
| Stewarts & Hamiltons | E! | 2015 | 1 | 8 | Reality |
| Stick | | 2025–on air | — | — | Comedy |
| Stick With Me, Kid | Disney Channel | 1995 | 1 | 13 | Sitcom |
| The Sticky | Prime Video | 2024 | 1 | 6 | — |
| Still Life | Fox | 2003–2004 | 1 | 6 | — |
| Still Standing | CBS | 2002–2006 | 4 | 88 | Sitcom |
| Still Star-Crossed | ABC | 2017 | 1 | 7 | Historical drama |
| Still the King | CMT | 2016–2017 | 2 | 26 | Sitcom |
| StillwaterAnimated series | Apple TV | 2020–on air | 5 | 40 | Children's |
| Stingray | NBC | 1985–1987 | 2 | 25 | Adventure |
| The Stinky & Dirty ShowAnimated series | Prime Video | 2015–2019 | 2 | 39 | — |
| Stir Crazy | CBS | 1985–1986 | 1 | 9 | — |
| Stitchers | Freeform | 2015–2017 | 3 | 31 | Speculative fiction |
| Stockard Channing in Just Friends | CBS | 1979 | 1 | 13 | Sitcom |
| The Stockard Channing Show | CBS | 1980 | 1 | 13 | Sitcom |
| Stolen Voices, Buried Secrets | Investigation Discovery | 2011–2012 | 3 | 40 | True crime |
| Stone | ABC | 1980 | 1 | 9 | Detective |
| Stone QuackersAnimated series | | 2014–2015 | 1 | 12 | Adult animation |
| The Stones | CBS | 2004 | 1 | 9 | Sitcom |
| Stoney Burke | ABC | 1962–1963 | 1 | 32 | Western |
| Storage Hunters | | 2011–2014 | 4 | 76 | Reality |
| Storage Wars | A&E | 2010–2019 | 12 | 269 | Reality |
| Storage Wars: Miami | A&E | 2015 | 1 | 10 | Reality |
| Storage Wars: New York | A&E | 2013 | 2 | 26 | Reality |
| Storage Wars: Texas | A&E | 2011–2014 | 3 | 78 | Reality |
| Storefront Lawyers | CBS | 1970–1971 | 1 | 23 | — |
| Stories of the Century | Syndication | 1954–1955 | 1 | 39 | Western |
| Storm Chasers | Discovery Channel | 2007–2011 | 5 | 36 | Reality |
| Storm HawksAnimated series | Cartoon Network, YTV | 2007–2009 | 2 | 52 | Science fiction |
| Storm of the CenturyMiniseries | ABC | 1999 | 1 | 3 | Adventure |
| Storm Stories | The Weather Channel | 2003–2010 | 9 | 371 | — |
| The Story of Diana | ABC | 2017 | — | — | Documentary |
| The Story of God with Morgan Freeman | National Geographic | 2016–2019 | 1 | 6 | Docufiction |
| The Story with Martha MacCallum | Fox News | 2017 | — | — | Talk show |
| Storybook Squares | NBC | 1969–1977 | — | 30 | Panel game |
| StoryBots Super Songs | Netflix | 2016 | 1 | 5 | — |
| Storytime with Thomas | television networks preceding ABC Family | 1999–2000 | 1 | 23 | — |
| Stossel | Fox Business | 2009–2016 | 7 | 309 | Talk show |
| Straightaway | ABC | 1961–1962 | 1 | 26 | — |
| The Strain | FX | 2014–2017 | 4 | 46 | Vampire |
| Stranded | Syfy | 2013 | 1 | 6 | Reality |
| Strange Angel | Paramount+ | 2018–2019 | 2 | 17 | Drama |
| Strange Days at Blake Holsey High | Discovery Family, Global Television Network | 2002–2006 | 4 | 42 | Science fiction |
| Strange Frequency | VH1 | 2001 | 1 | 12 | — |
| Strange Love | VH1 | 2005 | 1 | 11 | Reality |
| Strange Luck | Fox | 1995–1996 | 1 | 17 | — |
| Strange PlanetAnimated series | Apple TV | 2023–on air | — | — | Science fiction |
| Strange World | ABC | 1999 | 1 | 13 | Science fiction |
| The Stranger | Quibi | 2020–on air | 1 | 13 | Crime thriller |
| Stranger Things | Netflix | 2016–2025 | 5 | 42 | Fantasy |
| Stranger ThingsAnimated series | Netflix | 2026–on air | 2 | 18 | Horror |
| Strangers with Candy | Comedy Central | 1999–2000 | 3 | 30 | Black comedy |
| Strawberry ShortcakeAnimated series | CBS, Syndication | 2003–2008 | 4 | 22 | Comedy |
| Strawberry Shortcake: Berry in the Big CityAnimated series | Wildbrain Entertainment | 2021–2024 | 3 | 120 | Children's |
| Strawberry Shortcake's Berry Bitty AdventuresAnimated series | Hub Network | 2010–2015 | 4 | 65 | Children's |
| The Strawhatters | DuMont | 1953–1954 | — | — | — |
| The Street | Syndication | 1988 | — | — | — |
| Street Court | Syndication | 2009–2010 | 1 | 1 | Reality |
| Street Customs | TLC | 2007–2009 | 3 | 22 | Reality |
| Street FighterAnimated series | USA Action Extreme Team | 1995–1997 | 2 | 26 | — |
| Street Food | Netflix | 2019 | 1 | 9 | Documentary |
| Street Genius | National Geographic | 2013 | 2 | 32 | Documentary |
| Street Hawk | ABC | 1985 | 1 | 13 | Science fiction |
| Street Justice | Syndication | 1991–1993 | 2 | 44 | Crime |
| Street Outlaws | Discovery Channel | 2013 | 7 | 65 | — |
| Street Patrol | TruTV | 2008–2009 | — | 63 | Reality |
| Street SharksAnimated series | Syndication | 1994–1997 | 3 | 40 | Action |
| Street Smarts | Syndication | 2000–2005 | 5 | 19 | — |
| Street Time | Showtime | 2002–2003 | 2 | 33 | Detective |
| Streets of LaredoMiniseries | CBS | 1995 | 1 | 3 | Western |
| The Streets of San Francisco | ABC | 1972–1977 | 5 | 121 | Crime |
| Stressed EricAnimated series | BBC Two | 1998–2000 | 2 | 13 | Comedy |
| Stretch Armstrong & The Flex FightersAnimated series | Netflix | 2017–2018 | 1 | 13 | Comedy |
| Strike Back | Cinemax, Sky One | 2010–2020 | 8 | 76 | Action |
| Strike Force | ABC | 1981–1982 | 1 | 20 | — |
| Strike It Rich | Syndication | 1986–1987 | — | — | — |
| The Strip | UPN | 1999–2000 | 1 | 10 | Action |
| Strip Mall | Comedy Central | 2000–2001 | 2 | 20 | Sitcom |
| StripperellaAnimated series | Spike TV, Paramount Network | 2003–2004 | 1 | 13 | Adult animation |
| Stroker and HoopAnimated series | Adult Swim | 2004–2005 | 1 | 13 | Comedy |
| Strong | NBC | 2016 | 1 | 10 | — |
| Strong Bad EmailWeb series | | 2001 | — | 209 | Comedy |
| Strong Medicine | Lifetime | 2000–2006 | 6 | 132 | Drama |
| The Strongest Man in History | History | 2019 | 1 | 7 | Reality |
| Struck by Lightning | CBS | 1979 | 1 | 11 | Sitcom |
| Strut | Oxygen | 2016 | 1 | 6 | LGBTQ |
| The Stu Erwin Show | ABC, TBS Television | 1950–1955 | 4 | 130 | Sitcom |
| Stuart Fails to Save the Universe | HBO Max | 2026–on air | 1 | 10 | Sitcom |
| Stuart LittleAnimated series | HBO | 2003 | 1 | 13 | Comedy |
| Stuck in the Middle | Disney Channel | 2016–2018 | 3 | 57 | Comedy |
| Stuck with Hackett | Science Channel | 2011 | 1 | 9 | Documentary |
| The Studio | Apple TV | 2025–on air | 1 | 10 | Comedy |
| Studio 5-B | ABC | 1989 | 1 | 10 | — |
| Studio 57 | DuMont | 1954–1958 | 4 | 138 | Anthology |
| Studio 60 on the Sunset Strip | NBC | 2006–2007 | 1 | 22 | Comedy-drama |
| Studio 7 | The WB | 2004 | — | — | Game show |
| Studio C | BYUtv | 2012 | 21 | — | Sketch comedy |
| Studio See | PBS | 1977–1979 | 3 | 62 | — |
| Studs | Syndication | 1991–1993 | 3 | 580 | Game show |
| Studs' Place | WENR | 1949–1952 | — | — | — |
| Stuff You Should Know | Science Channel | 2013 | 1 | 11 | Comedy |
| StuGo | Disney Channel | 2025–on air | 1 | 40 | Comedy |
| Stumble | NBC | 2025–2026 | 1 | 13 | Comedy |
| Stump the Schwab | ESPN2 | 2004–2006 | 4 | 80 | Game show |
| Stumpers | NBC | 1976 | 1 | 65 | Game show |
| Stumptown | ABC | 2019–2020 | 1 | 18 | — |
| Style & Substance | CBS | 1998 | 1 | 13 | Sitcom |
| Styled to Rock | Bravo | 2013 | 1 | 10 | Reality |
| Styling Hollywood | Netflix | 2019–on air | 1 | 8 | Reality |
| Stylista | The CW | 2008 | 1 | 9 | Reality |
| Submission | Showtime | 2016 | 1 | 6 | Thriller |
| Submissions OnlyWeb series | | 2010–2014 | 3 | 19 | Comedy |
| Suburgatory | ABC | 2011–2014 | 3 | 57 | Teen sitcom |
| Succession | HBO | 2018–2023 | 4 | 39 | Comedy-drama |
| Suddenly Susan | NBC | 1996–2000 | 4 | 93 | Sitcom |
| Sue Thomas: F.B.Eye | Ion Television, CTV Television Network | 2002–2005 | 3 | 56 | Crime |
| Sugar | YouTube Premium, YouTube | 2018–on air | — | 8 | Reality |
| Sugar | Apple TV | 2024–on air | 2 | 16 | Mystery |
| Sugar and Spice | CBS | 1990 | 1 | 7 | Sitcom |
| Sugar and Toys | Fuse | 2019–2020 | — | — | Comedy |
| Sugar Dome | Food Network | 2012 | 1 | 6 | Reality |
| Sugar Rush | Netflix | 2018–2020 | 3 | 32 | Reality |
| Sugar Time! | ABC | 1977–1978 | 2 | 13 | Sitcom |
| Sugarfoot | ABC | 1957–1961 | 4 | 69 | Western |
| Suite 7Web series | Lifetime | 2010–2011 | 1 | 8 | Anthology |
| The Suite Life of Zack and Cody | Disney Channel | 2005–2008 | 3 | 87 | Teen sitcom |
| The Suite Life on Deck | Disney Channel, ABC | 2008–2011 | 3 | 71 | Teen sitcom |
| Suits | USA Network | 2011–2019 | 9 | 134 | Legal drama |
| Suits LA | NBC | 2025 | 1 | 13 | — |
| Sullivan & Son | TBS | 2012–2014 | 3 | 33 | Sitcom |
| Summer Breeze | NBC | 1987 | — | 1 | — |
| Summer Camp IslandAnimated series | Cartoon Network, HBO Max | 2018–2023 | 6 | 120 | Adventure |
| Summer House | Bravo | 2017 | 4 | 48 | Reality |
| The Summer I Turned Pretty | Prime Video | 2022–2025 | 3 | 26 | Romantic |
| Summerland | The WB | 2004–2005 | 2 | 26 | Drama |
| The Summit | CBS | 2024 | — | — | Reality competition |
| Sun Records | CMT | 2017 | 1 | 2 | — |
| Sunday Best | BET | 2007–2015 | 8 | 62 | — |
| Sunday Dinner | CBS | 1991 | 1 | 6 | Sitcom |
| Sunday Morning Futures With Maria Bartiromo | Fox News | 2014 | — | — | News |
| Sunday Night | NBC | 1988–1990 | — | 44 | — |
| Sunday Night Baseball | ESPN | 1990 | 27 | — | — |
| Sunday Night Hockey | NBC | 2016–2021 | 1 | 13 | — |
| Sunday Night in America with Trey Gowdy | Fox News | 2021–on air | 3 | — | Political magazine show |
| Sunday Night Sex Show | W Network | 1996–2008 | — | — | Reality |
| Sunday Night with Megyn Kelly | NBC | 2017 | 1 | 8 | — |
| Sunday Pants | Cartoon Network | 2005 | 1 | 7 | — |
| Sunny | Apple TV | 2024–on air | — | — | Drama |
| Sunny Day: Style of GirlsAnimated series | Nick Jr. | 2026–on air | 1 | 1 | Crossover |
| Sunnyside | NBC | 2019 | — | 11 | Comedy |
| Sunrise Semester | CBS | 1957–1982 | 25 | 800 | — |
| Sunset Beach | NBC | 1997–1999 | 3 | 755 | Soap opera |
| Sunset Beat | ABC | 1990–1992 | 1 | 6 | — |
| Sunset Limousine | CBS | 1983 | — | — | — |
| Sunset Tan | E! | 2007–2008 | 2 | 20 | Reality |
| Sunshine | NBC | 1975 | 1 | 13 | Comedy |
| Supah Ninjas | Nickelodeon, TeenNick | 2011–2013 | 2 | 38 | Action |
| The Super | ABC | 1972 | 1 | 10 | Sitcom |
| The Super 6 | NBC | 1966–1967 | — | 60 | — |
| Super Adventure Team | MTV | 1998 | 1 | 6 | Science fiction |
| Super Best Friends ForeverMiniseries | Cartoon Network | 2012 | 1 | 5 | Action |
| Super Bikes! | Speed | 2006 | 4 | 48 | — |
| Super Dave | Showtime | 1987–1992 | 5 | 95 | Sketch comedy |
| Super Dave: Daredevil for HireAnimated series | Fox | 1992–1993 | 1 | 13 | Comedy |
| Super Duper SumosAnimated series | YTV | 2002–2003 | 2 | 26 | Comedy |
| Super Force | Syndication | 1990–1992 | 2 | 48 | Science fiction |
| Super FriendsAnimated series | ABC | 1973–1985 | 9 | 109 | — |
| Super Friends | ABC | 1980–1982 | 3 | 22 | — |
| Super Friends: The Legendary Super Powers ShowAnimated series | ABC | 1984–1985 | — | 8 | Science fiction |
| Super Fun Night | ABC | 2013–2014 | 1 | 17 | Sitcom |
| Super Giant Robot BrothersAnimated series | Netflix | 2022–on air | — | — | Adventure |
| The Super Globetrotters | NBC | 1979 | 1 | 13 | Animation |
| The Super Hero Squad ShowAnimated series | Cartoon Network | 2009–2011 | 2 | 52 | Comedy |
| The Super Mario Bros. Super Show!Animated series | CBS | 1989 | 1 | 52 | Fantasy |
| Super Mario WorldAnimated series | NBC | 1991 | 1 | 13 | Comedy |
| Super MonstersAnimated series | Netflix | 2017–2021 | 3 | 22 | Children's |
| The Super PopsWeb series | Totally TV, YouTube | 2019–on air | 1 | 12 | Musical |
| The Super Powers Team: Galactic GuardiansAnimated series | ABC | 1985–1986 | — | 10 | Science fiction |
| Super PresidentAnimated series | NBC | 1967–1968 | 1 | 30 | Children's |
| Super Pumped | Showtime | 2022–on air | — | — | Anthology |
| Super PupZ | Netflix | 2022 | 1 | 9 | Adventure |
| Super Robot Monkey Team Hyperforce Go!Animated series | Jetix, Disney XD | 2004–2006 | 4 | 52 | Anime-influenced animation |
| Super Why!Animated series | CBC Kids, PBS Kids | 2007–2016 | 3 | 103 | Music |
| Super WingsAnimated series | Carousel, Korea Educational Broadcasting System | 2014 | 10 | 424 | Educational |
| SuperbookAnimated series | Christian Broadcasting Network | 2011–2021 | 4 | 52 | — |
| Superboy | Syndication | 1988–1992 | 4 | 100 | Superhero |
| Supercarrier | ABC | 1988 | 1 | 9 | Drama |
| SuperF*ckersWeb series | | 2012–2013 | 1 | 12 | Comedy |
| SuperFetch | Animal Planet | 2009 | 1 | 20 | — |
| Supergirl | CBS, The CW | 2015–2021 | 6 | 126 | Drama |
| Supergroup | VH1 | 2006 | — | 7 | Reality |
| Superhero Landing | | 2019–on air | 1 | 12 | Superhero |
| Superhero RoommateWeb series | | 2000 | — | — | Superhero |
| Superheroes: A Never-Ending Battle | PBS | 2013 | — | 3 | Documentary |
| Superhuman Samurai Syber-Squad | Syndication | 1994–1995 | 1 | 53 | Tokusatsu |
| Superior Donuts | CBS | 2017–2018 | 1 | 2 | Sitcom |
| Superjail!Animated series | Adult Swim | 2007–2014 | 4 | 36 | Adult animation |
| SuperKittiesAnimated series | Disney Jr. | 2023–on air | 2 | 41 | — |
| SupermanAnimated series | CBS | 1988 | 1 | 13 | Action |
| SupermanAnimated series | Kids' WB, The WB | 1996–2000 | 3 | 54 | Science fiction |
| Superman & Lois | The CW | 2021–2024 | 4 | 53 | Fantasy |
| The Superman/Aquaman Hour of Adventure | CBS | 1967–1968 | — | 36 | — |
| Supermarket Superstar | Lifetime | 2013 | 1 | 10 | — |
| Supermarket Sweep | Ion Television, ABC | 1965–2022 | 10 | 1,111 | Game show |
| SupermodelsAnimated series | Antena 3 | 1999–2000 | — | — | — |
| Supernanny | RTL | 2004–2020 | 7 | 145 | Docu-soap |
| Supernatural | The WB, TNT | 2005–2020 | 15 | 327 | Drama |
| Supernatural AcademyAnimated series | Peacock | 2022–on air | — | — | Fantasy |
| Supernatural: Bloodlines | The CW | 2014 | 1 | 1 | Drama |
| SuperNews!Animated series | Current TV | 2005–2010 | 2 | 67 | Comedy |
| Superpowered: The DC StoryMiniseries | HBO Max | 2023 | 1 | 3 | Historical documentary |
| Superstars | TV3 Sverige | 1973–2012 | 17 | — | — |
| Superstars of Dance | NBC | 2009 | 1 | 5 | Reality |
| Superstition | Syfy | 2017–2018 | 1 | 12 | Drama |
| Superstore | NBC | 2015–2021 | 6 | 113 | Sitcom |
| Supertrain | NBC | 1979 | 1 | 9 | Science fiction |
| Surface | NBC | 2005–2006 | 1 | 16 | Science fiction |
| Surface | Apple TV | 2022–on air | 2 | 16 | — |
| Surfside 6 | ABC | 1960–1962 | 2 | 74 | Crime |
| Surgery Saved My Life | Discovery Channel | 2006–2008 | 1 | 20 | Documentary |
| The Surreal Life | The WB | 2003–2006 | 6 | 61 | Reality |
| The Surreal Life: Fame Games | VH1 | 2007 | 1 | 10 | Reality |
| Survival of the Thickest | Netflix | 2023–on air | — | — | Comedy-drama |
| Surviving Black Hawk Down | Netflix | 2025–on air | 1 | 3 | Documentary |
| Surviving Death | Netflix | 2021–on air | — | — | Documentary |
| Surviving Disaster | Paramount Network | 2009 | 1 | 10 | — |
| Surviving History | History | 2008 | 1 | 9 | — |
| Surviving Jack | Fox | 2014 | 1 | 13 | Sitcom |
| Surviving Nugent | VH1 | 2003–2004 | — | — | Reality |
| Surviving R. Kelly | Lifetime | 2019–2020 | 1 | 6 | Documentary |
| Surviving Suburbia | ABC | 2009 | 1 | 13 | Sitcom |
| Surviving the Cut | Discovery Channel | 2010–2011 | 2 | 12 | — |
| Survivor | CBS | 2000 | 50 | 722 | Reality |
| Survivor's Remorse | Starz | 2014–2017 | 4 | 36 | — |
| The Susan Powter Show | Syndication | 1994–1995 | — | — | Talk show |
| Suspense | ABC | 1949–1954 | 6 | 260 | Anthology |
| Suspicion | NBC | 1957–1958 | 1 | 42 | Thriller |
| Svengoolie | MeTV, WCIU-TV | 1970 | — | 680 | — |
| Svetlana | | 2010–2011 | 2 | 24 | Comedy |
| The Swamp Critters of Lost Lagoon | PBS | 1995–1997 | 4 | 39 | — |
| The Swamp Fox | ABC | 1959–1961 | 2 | 8 | — |
| Swamp Loggers | Discovery Channel | 2008–2012 | 4 | 35 | Reality |
| Swamp People | History | 2010 | 7 | 130 | Documentary |
| Swamp Thing | USA Network | 1990–1993 | 3 | 72 | Science fiction |
| Swamp ThingAnimated series | Fox, USA Network | 1990–1991 | — | 5 | Comedy |
| Swamp Thing | DC Universe | 2019 | 1 | 10 | Science fiction |
| Swans Crossing | Syndication | 1992 | 1 | 65 | Soap opera |
| Swarm | Prime Video | 2023–on air | 1 | 7 | Thriller |
| SWAT Kats: The Radical SquadronAnimated series | TBS | 1993–1995 | 2 | 23 | Action game |
| Swedish Dicks | Pop, Viaplay | 2016–2018 | 2 | 20 | Crime |
| Sweet Genius | Food Network | 2011–2013 | 3 | 34 | — |
| Sweet Justice | NBC | 1994–1995 | 1 | 22 | — |
| Sweet Magnolias | Netflix | 2020–on air | 5 | 50 | Drama |
| Sweet Surrender | NBC | 1987 | 1 | 6 | Sitcom |
| Sweet Tooth | Netflix | 2021–on air | 3 | 24 | Fantasy |
| Sweet Valley High | Fox, UPN | 1994–1997 | 4 | 88 | Comedy-drama |
| Sweet/Vicious | MTV | 2016–2017 | 1 | 10 | College life |
| Sweetbitter | Starz | 2018–2019 | 2 | 12 | — |
| Swift Justice | UPN | 1996 | 1 | 13 | — |
| Swift Justice with Jackie Glass | Syndication | 2010–2012 | 2 | — | — |
| Swimming with Sharks | The Roku Channel | 2022–on air | — | 6 | Psychological drama |
| Swing | Playboy TV | 2011–2015 | 5 | 44 | Reality |
| Swinging Spiketaculars | CBS | 1960 | 1 | 8 | — |
| Swingtown | CBS | 2008 | 1 | 13 | Period drama |
| The Swiss Family Robinson | ABC | 1975–1976 | 1 | 20 | Action |
| Switch | CBS | 1975–1978 | 3 | 71 | Crime |
| Switched! | Freeform | 2003–2004 | 2 | 73 | Reality |
| Switched at Birth | Freeform | 2011–2017 | 5 | 103 | Drama |
| Sword of Justice | NBC | 1978–1979 | 1 | 10 | — |
| Swords | Discovery Channel | 2009–2012 | 3 | 24 | — |
| Sydney | CBS | 1990 | 1 | 13 | Sitcom |
| Sydney to the Max | Disney Channel | 2019–2021 | 3 | 63 | Sitcom |
| Sylvanian FamiliesAnimated series | Syndication | 1987 | 1 | 13 | Fantasy |
| The Sylvester & Tweety MysteriesAnimated series | Kids' WB, The WB | 1995–2000 | 5 | 52 | Comedy |
| Sym-Bionic TitanAnimated series | Cartoon Network | 2010–2011 | 1 | 20 | Science fiction |
| The SympathizerMiniseries | HBO | 2024 | — | 7 | War drama |
| Szysznyk | CBS | 1977–1978 | 2 | 15 | Sitcom |