| The $1,000,000 Chance of a Lifetime | Syndication | 1986–1987 | 2 | — | Game show |
| 1,000 Places to See Before You Die | Travel Channel | 2007 | 1 | 13 | Travel documentary |
| The $1.98 Beauty Show | | 1978–1980 | 2 | 78 | Game show |
| The 1% Club | Prime Video, Fox | 2024–on air | 1 | 5 | Game show |
| 1 Day With | Soapnet | 2004–2005 | — | 19 | Reality |
| 1 vs. 100 | Game Show Network, NBC | 2006–2008 | 3 | 68 | Game show |
| 10.5Miniseries | NBC | 2004 | 1 | 2 | Disaster |
| 10.5: ApocalypseMiniseries | NBC | 2006 | 1 | 2 | Disaster |
| 10-8 | ABC | 2003–2004 | 1 | 15 | Drama |
| 10 Items or Less | TBS | 2006–2009 | 3 | 21 | Sitcom |
| 10 Million Dollar Bigfoot Bounty | Paramount Network, Spike TV | 2014 | 1 | 8 | Reality |
| 10 Seconds | The Nashville Network | 1993 | 1 | 130 | — |
| 10 Things I Hate About You | Freeform | 2009–2010 | 1 | 20 | Sitcom |
| 10 Years Younger | TLC | 2004–2009 | 3 | 212 | Reality |
| The 100 | The CW | 2014–2020 | 7 | 100 | LGBTQ |
| $100,000 Fortune Hunt | WGN-TV | 1989–1994 | 5 | 50 | Game show |
| 100 Centre Street | A&E | 2001–2002 | 2 | 31 | LGBTQ |
| 100 Days of Summer | Bravo | 2014 | 1 | 8 | Reality |
| 100 Deeds for Eddie McDowd | Nickelodeon | 1999–2002 | 3 | 40 | Teen sitcom |
| 100 días para enamorarnos | Telemundo | 2020 | 1 | 57 | Telenovela |
| 100 Grand | ABC | 1963 | — | 3 | Game show |
| 100 Humans | Netflix | 2020–on air | 1 | 8 | Reality |
| 100 latinos dijeron | Estrella TV, MundoMax | 2013 | 1 | 21 | Game show |
| The 100 Lives of Black Jack Savage | NBC | 1991 | 1 | 7 | Comedy |
| 100 Questions | NBC | 2010 | 1 | 6 | Sitcom |
| 100 Things to Do Before High School | Nickelodeon | 2014–2016 | 1 | 25 | Sitcom |
| 100 Winners | Game Show Network | 2007 | — | 51 | Game show |
| 1000-lb Sisters | TLC | 2020–on air | 3 | 28 | Reality |
| 1000 Ways to Die | Spike TV | 2008–2012 | 4 | 74 | Mockumentary |
| 1000 Ways to Lie | Spike TV | 2010 | 1 | 1 | Documentary |
| 101 Dalmatians: The SeriesAnimated series | ABC, Syndication | 1997–1998 | 3 | 65 | Children's |
| 101 Ways to Leave a Game Show | ABC | 2011 | 1 | 6 | Reality |
| 11-11: En mi cuadra nada cuadra | Nickelodeon Latin America | 2013 | 1 | 75 | Telenovela |
| 11.22.63Miniseries | Hulu | 2016 | 1 | 8 | Thriller |
| The 11th Hour | MS NOW | 2016 | 6 | — | News |
| 12 12 12 | Apple TV | 2026upcoming | — | — | Caper story |
| 12 Corazones | Telemundo | 2005–2017 | 6 | — | Dating game show |
| The ½ Hour News Hour | Fox News | 2007 | — | 17 | — |
| 12 Monkeys | Syfy | 2015–2018 | 4 | 47 | Science fiction |
| 12 oz. MouseAnimated series | Adult Swim, Cartoon Network | 2005–2018 | 3 | 22 | Exploitation |
| 120 Minutes | MTV | 1991 | — | — | — |
| The $128,000 Question | Syndication | 1976–1978 | — | — | Game show |
| 13: Fear Is Real | The CW | 2009 | 1 | 8 | Reality |
| The 13 Ghosts of Scooby-DooAnimated series | ABC | 1985 | 1 | 13 | Horror |
| 13 Queens Boulevard | ABC | 1979 | 1 | 9 | Sitcom |
| 13 Reasons Why: Beyond the Reasons | Netflix | 2017–2019 | 3 | 3 | Aftershow |
| 16 and Pregnant | MTV | 2009–2014 | 5 | 61 | Reality |
| 1600 Penn | NBC | 2012–2013 | 1 | 13 | Sitcom |
| 18 Wheels of Justice | Spike TV | 2000–2001 | 2 | 44 | — |
| 1883 | Paramount+ | 2021–2022 | 1 | 10 | Western |
| 19 Kids and Counting | TLC | 2008–2015 | 10 | 244 | Reality |
| 1923 | Paramount+ | 2022–on air | 2 | 15 | Drama |
| The 1940s House | Channel 4 | 2002 | 1 | 5 | — |
| 1986 | NBC | 1986 | 1 | — | News magazine |
| 1st & Ten | HBO | 1984–1991 | 6 | 80 | Sitcom |
| 2 Broke Girls | CBS | 2011–2017 | 6 | 138 | Sitcom |
| 2 Minute Drill | ESPN | 2000–2001 | 3 | 52 | Game show |
| 2 Months 2 Million | G4 | 2009 | 1 | 10 | Reality |
| 2 Stupid DogsAnimated series | Cartoon Network, TBS | 1993–1995 | 2 | 39 | Comedy |
| 20,000 Leagues Under the SeaMiniseries | ABC | 1997 | 1 | 2 | Science fiction |
| 20/20News program | ABC | 1978 | 38 | 500 | News |
| 20 Minute Workout | Citytv | 1983–1985 | 2 | — | — |
| 2000 Malibu Road | CBS | 1992 | 1 | 6 | Soap opera |
| The 2000s | CNN | 2018 | 1 | 7 | — |
| 2057 | Discovery Channel | 2007 | — | 3 | — |
| The (206) | KING-TV | 2013–2015 | — | — | Variety show |
| 20Q | Game Show Network | 2009 | 1 | 9 | — |
| The 20th Century Fox Hour | CBS | 1955–1957 | 2 | 37 | Anthology |
| 21 Beacon Street | NBC | 1959 | — | — | Detective |
| 21 Jump Street | Fox | 1987–1991 | 5 | 103 | Police procedural |
| 227 | NBC | 1985–1990 | 5 | 116 | Sitcom |
| 24 | Fox | 2001–2010 | 8 | 192 | Crime |
| 24 Hour Restaurant Battle | Food Network | 2010–2011 | 2 | 18 | Reality |
| $24 in 24 | Food Network | 2012 | 1 | 7 | Reality |
| 24: Legacy | Fox | 2017 | 1 | 12 | Espionage |
| 24: Live Another Day | Fox | 2014 | 1 | 12 | Crime |
| 240-Robert | ABC | 1979–1981 | 2 | 16 | Drama |
| $25 Million Dollar Hoax | NBC | 2004 | — | 3 | Reality |
| 26 Men | Syndication | 1957–1959 | 2 | 78 | Western |
| 2gether: The Series | MTV | 2000–2001 | 2 | 20 | Sitcom |
| 3 | CBS | 2012 | 1 | 2 | Reality |
| 3-2-1 Contact | PBS | 1980–1988 | 7 | 225 | — |
| 3-2-1 Penguins! | Qubo | 2000–2008 | 3 | 27 | Computer animation |
| 3 Body Problem | Netflix | 2024–on air | 1 | 8 | Drama |
| 3 Girls 3 | NBC | 1977 | 1 | 4 | — |
| 3 lbs | CBS | 2006 | 1 | 8 | Medical drama |
| 3-SouthAnimated series | MTV | 2002–2003 | 1 | 13 | Animated sitcom |
| 30 Days | FX | 2005–2008 | 3 | 18 | Documentary |
| 30 Days of Night: Dust to DustMiniseries | Fearnet | 2007–2008 | — | — | Vampire |
| 30 Minute Meals | Food Network | 2001–2012 | — | — | — |
| 30 Rock | NBC | 2006–2013 | 7 | 138 | Satire |
| 30 Rock: A One-Time Special | NBC | 2020–on air | — | — | Comedy |
| 30 Seconds to Fame | Fox | 2002–2003 | 2 | 16 | — |
| 36 | NBCSN | 2011–2013 | — | 11 | Reality |
| 3BelowAnimated series | Netflix | 2018–2019 | 2 | 26 | Comedy |
| 3rd Degree | Syndication | 1989–1990 | — | 195 | Panel game |
| 3rd Rock from the Sun | NBC | 1996–2001 | 6 | 139 | Science fiction |
| $40 a Day | Food Network | 2002–2005 | 4 | 77 | — |
| 413 Hope St. | Fox | 1997–1998 | 1 | 10 | Drama |
| The 4400 | USA Network | 2004–2007 | 4 | 45 | Science fiction |
| 4400 | The CW | 2021–2022 | 1 | 13 | Mystery |
| 45/85 | ABC | 1985 | — | 1 | Documentary |
| The 45 Rules of Bossing Up | MBC 4 | 2021–2022 | 5 | 45 | Comedy-drama |
| 48 HoursNews program | CBS, Investigation Discovery | 1988–2004 | 29 | 991 | Documentary |
| 48 Hours: Hurricane Watch | CBS | 1989 | — | — | Magazine format |
| 4th and Loud | AMC | 2014 | 1 | 10 | Reality |
| The 5 Mrs. Buchanans | CBS | 1994–1995 | 1 | 17 | Sitcom |
| 50 Cent: The Money and the Power | MTV2, MTV | 2008–2009 | 1 | 10 | Reality |
| 50 Documentaries to See Before You Die | Current TV | 2011 | 1 | 5 | Documentary |
| 50 Grand Slam | NBC | 1976 | — | 65 | Game show |
| 50 Minutes Sports | Showtime | 2013–2017 | 3 | 27 | News |
| 50 States of Fright | Quibi | 2020 | 1 | 8 | Horror |
| 500 Questions | ABC | 2015–2016 | 1 | 12 | Quiz show |
| 5ive Days to MidnightMiniseries | Syfy | 2004 | 1 | 5 | Mystery fiction |
| The 5th Wheel | Syndication | 2001–2004 | 3 | — | Reality |
| 6 Little McGhees | OWN | 2012–2014 | 3 | 31 | Reality |
| 60 Days In | A&E | 2016 | — | 13 | — |
| 60 MinutesNews program | CBS | 1968 | 57 | 2,325 | Documentary |
| 60 Minutes IINews program | CBS | 1999–2005 | — | — | News magazine |
| The $64,000 Question | CBS | 1955–1958 | 4 | — | Game show |
| 666 Park Avenue | ABC | 2012–2013 | 1 | 13 | Paranormal |
| 68 Whiskey | Paramount Network | 2020 | 1 | 10 | War |
| 7 Lives Exposed | Playboy TV | 2001–2006 | 5 | 84 | Reality |
| 704 Hauser | CBS | 1994 | 1 | 6 | Sitcom |
| 72 Hours | TNT | 2013 | 1 | 8 | Reality |
| 765874 (Series) - Episode List | YouTube | 2022–on air | — | 4 | Science fiction |
| 77 Sunset Strip | ABC | 1958–1964 | 6 | 206 | Drama |
| The 7DAnimated series | Disney XD | 2014–2016 | 2 | 44 | Adventure |
| 7th Heaven | The CW, The WB | 1996–2007 | 11 | 243 | Drama |
| 8 Minutes | A&E | 2015 | 1 | 5 | Reality |
| 8 Simple Rules | ABC | 2002–2005 | 3 | 76 | Sitcom |
| 8-Track Flashback | VH1 | 1995–1998 | 4 | — | — |
| The '80s: The Decade That Made Us | National Geographic | 2013 | 1 | 10 | — |
| 87th Precinct | NBC | 1961–1962 | 1 | 30 | Police procedural |
| 8th & Ocean | MTV | 2006 | 1 | 10 | Reality |
| 9-1-1 | Fox, ABC | 2018–on air | 9 | 142 | Drama |
| 9-1-1: Lone Star | Fox | 2020–2025 | 5 | 72 | LGBTQ |
| 9-1-1: Nashville | ABC | 2025–on air | 1 | 18 | — |
| 9 By Design | Bravo | 2010 | 1 | 8 | Reality |
| 9 to 5 | ABC | 1982–1988 | 5 | 85 | Sitcom |
| 90 Day Fiancé | TLC | 2014 | 7 | 79 | Reality |
| 90 Day Fiancé: Happily Ever After? | TLC | 2016 | 7 | 105 | Reality |
| 90210 | The CW | 2008–2013 | 5 | 114 | Youth |
| 99 to Beat | Fox | 2025–on air | 1 | 10 | Game show |
| 9JKL | CBS | 2017–2018 | 1 | 16 | Comedy |