| E.A.R.T.H. Force | CBS | 1990 | 1 | 6 | — |
| E! Hollywood Hold'em | E! | 2005 | 1 | 6 | — |
| E/R | CBS | 1984–1985 | 1 | 22 | Sitcom |
| E-Ring | NBC | 2005–2006 | 1 | 22 | Drama |
| E!'s Pam: Girl on the Loose! | E! | 2008 | 1 | 8 | Reality |
| E! True Hollywood Story | E! | 1996 | 17 | 443 | Documentary |
| Eagle RidersAnimated series | UPN | 1996–1997 | — | 65 | Comedy |
| Eagleheart | Adult Swim | 2011–2014 | 3 | 34 | Comedy |
| Early Edition | CBS | 1996–2000 | 4 | 90 | Fantasy |
| The Early ShowNews program | CBS | 1954–2012 | 13 | 3,578 | News |
| Early StartNews program | CNN | 2012–2024 | — | — | News |
| Early Today | NBC | 1999 | 16 | — | News |
| Earth 2 | NBC | 1994–1995 | 1 | 22 | Science fiction |
| Earth Abides | MGM+ | 2024–on air | 1 | 6 | Science fiction |
| Earth: Final Conflict | CTV 2, CTV Television Network | 1997–2002 | 5 | 110 | Science fiction |
| Earth Moods | Disney Channel, Disney+ | 2021–on air | 1 | 5 | — |
| Earth Revealed: Introductory Geology | PBS | 1992 | — | 26 | Documentary |
| Earth to Luna! | NBC Kids, Universal Kids/MeTV Toons | 2014–2017 | 1 | 52 | — |
| Earth to Ned | Disney+ | 2020–2021 | 1 | 10 | — |
| EarthseaMiniseries | Syfy, Antena 3 | 2004 | 1 | 2 | Fantasy |
| Earthworm JimAnimated series | The WB | 1995–1996 | 2 | 23 | Comedy |
| East Los High | Hulu | 2013–2017 | 3 | 48 | Teen drama |
| East New York | CBS | 2022–2023 | 1 | 21 | Detective |
| East of EdenMiniseries | ABC | 1981 | — | — | Drama |
| East of Eden | Netflix | 2026 | 1 | 7 | Drama |
| East Side/West Side | CBS | 1963–1964 | 1 | 26 | Drama |
| Eastbound & Down | HBO | 2009–2013 | 4 | 29 | Comedy |
| EastSidersWeb series | Netflix, Logo TV | 2012–2019 | 3 | 21 | LGBTQ |
| Eastwick | ABC | 2009–2010 | 1 | 13 | Fantasy |
| Easy | Netflix | 2016–2019 | 3 | 25 | Anthology |
| Easy Money | The CW | 2008–2009 | 1 | 8 | Drama |
| Easy Street | NBC | 1986–1987 | 1 | 22 | Sitcom |
| Easy to AssembleWeb series | | 2008–2012 | 4 | 48 | Comedy |
| Eat: The Story of Food | National Geographic | 2014 | 1 | 6 | — |
| Ebert Presents: At the Movies | PBS | 2011 | 1 | 51 | — |
| Echo | Disney+, Hulu | 2024 | 1 | 5 | Action |
| Echo 3 | Apple TV | 2022–2023 | 1 | 10 | Drama |
| ECW Hardcore TV | Syndication, America One | 1993–2000 | 8 | 401 | — |
| ECW on TNN | Paramount Network, The Nashville Network | 1999–2000 | — | 59 | — |
| Ed | NBC | 2000–2004 | 4 | 83 | Comedy-drama |
| Ed, Edd n EddyAnimated series | Cartoon Network | 1999–2009 | 6 | 69 | Comedy |
| The Ed Sullivan Show | CBS | 1948–1971 | 24 | 1,068 | Entertainment |
| The Ed Wynn Show | CBS | 1949–1950 | 1 | 39 | — |
| The Eddie Cantor Comedy Theatre | Syndication | 1955 | 1 | 39 | — |
| The Eddie Capra Mysteries | NBC | 1978–1979 | 1 | 13 | Detective |
| Eddie Dodd | ABC | 1991 | 1 | 6 | — |
| The Eddie Fisher Show | NBC | 1957–1959 | 2 | 27 | — |
| Eddie Griffin: Going For Broke | VH1 | 2009 | 1 | 6 | Reality |
| The Eddy | Netflix | 2020–on air | 1 | 8 | Musical |
| The Eddy Arnold Show | CBS | 1952 | 3 | 22 | — |
| Edgar & EllenAnimated series | Nickelodeon, Nicktoons | 2007–2008 | 2 | 24 | Comedy |
| The Edge | Fox | 1992–1993 | 1 | 18 | Comedy |
| Edge of Alaska | Discovery Channel | 2014–2017 | 2 | 18 | — |
| Edge of America | Travel Channel | 2013 | 1 | 10 | — |
| The Edge of Night | CBS | 1956–1984 | 28 | 7,420 | Soap opera |
| Edge of Normal | YouTube | 2013 | 1 | 6 | — |
| The Edge of Sleep | Prime Video | 2024–on air | — | 6 | — |
| The Education of Max Bickford | CBS | 2001–2002 | 1 | 22 | LGBTQ |
| Eek! The CatAnimated series | Fox | 1992–1997 | 5 | 63 | Comedy |
| Eerie, Indiana | NBC | 1991–1992 | 1 | 19 | Science fiction |
| Eerie, Indiana: The Other Dimension | Fox Kids | 1998 | 1 | 15 | — |
| EGG, the Arts Show | PBS | 2000–2005 | 4 | 41 | — |
| Ego trip's Miss Rap Supreme | VH1 | 2008 | — | — | Reality |
| Ego trip's The (White) Rapper Show | VH1 | 2007 | 1 | 8 | Reality |
| EgyxosAnimated series | Super! | 2015 | — | 26 | Fantasy |
| Eight Is Enough | ABC | 1977–1981 | 5 | 112 | Comedy-drama |
| The Eighties | CNN | 2016 | 1 | 7 | Documentary |
| Eischied | NBC | 1979–1980 | 1 | 13 | Drama |
| Eisenhower and Lutz | CBS | 1988 | 1 | 13 | Sitcom |
| El amor no tiene precio | Las Estrellas | 2005–2006 | — | 280 | Telenovela |
| El Chapo | Univision | 2017–2018 | 3 | 34 | Drama |
| El Clon | Telemundo | 2010 | 1 | 181 | Telenovela |
| El Comandante | Canal RCN | 2017 | 1 | 102 | Telenovela |
| El Conde: amor y honor | Telemundo | 2024 | 1 | 75 | Drama |
| El DoradoMiniseries | British Broadcasting Corporation | 2010 | 1 | 2 | Drama |
| El Fantasma de Elena | Telemundo | 2010–2011 | 1 | 117 | Telenovela |
| El Mariachi | AXN | 2014 | — | 71 | Thriller |
| El Talismán | Venevisión | 2012 | — | 98 | Telenovela |
| El Tigre: The Adventures of Manny RiveraAnimated series | Nickelodeon | 2007–2008 | 1 | 26 | Comedy |
| Elder Michaux | WTTG | 1948–1949 | — | — | — |
| Electra Woman and Dyna Girl | ABC, TV Land | 1976–1977 | — | 16 | Children's |
| Electric CityWeb series | | 2012 | 1 | 20 | Dystopian |
| The Electric Company | PBS | 1971–1977 | 6 | 780 | — |
| The Electric Company | PBS Kids Go! | 2009–2011 | 3 | 52 | Fantasy |
| Elementary | CBS | 2012–2019 | 7 | 154 | Crime |
| Elena of AvalorAnimated series | Disney Channel | 2016–2020 | 3 | 25 | Fantasy |
| The Eleventh Hour | NBC | 1962–1964 | 2 | 62 | — |
| Eleventh Hour | CBS | 2008–2009 | 1 | 18 | Drama |
| Eli Stone | ABC | 2008–2009 | 2 | 26 | Musical |
| Elinor Wonders WhyAnimated series | PBS Kids | 2020–on air | — | 40 | Educational |
| Elizabeth IMiniseries | HBO | 2005 | 1 | 2 | Drama |
| Elizabeth Stanton's Great Big World | Syndication | 2011–2019 | 6 | 91 | — |
| Ellen | ABC | 1994–1998 | 5 | 109 | LGBTQ |
| The Ellen Burstyn Show | ABC | 1986–1987 | 1 | 13 | Sitcom |
| The Ellen DeGeneres Show | Syndication | 2003–2022 | 19 | 3,339 | Talk show |
| Ellen's Acres | Cartoon Network | 2006–2007 | — | 52 | — |
| Ellen's Game of Games | NBC | 2017–2021 | — | 9 | Reality |
| The Ellen Show | CBS | 2001–2002 | 1 | 18 | LGBTQ |
| Ellery Queen | NBC | 1975–1976 | 1 | 23 | Detective |
| Ellis IslandMiniseries | CBS | 1984 | — | 3 | — |
| Eloise Salutes the Stars | DuMont | 1950–1951 | 1 | 26 | — |
| Eloise: The Animated SeriesAnimated series | Starz | 2006 | 1 | 13 | Comedy |
| Elsbeth | CBS | 2024–on air | 3 | 50 | — |
| Elvis | ABC | 1990 | 1 | 13 | Drama |
| ElvisMiniseries | CBS | 2005 | — | 2 | Biography |
| Elvis and Slick Monty | NTTV | 2004–2006 | 2 | 10 | — |
| Embeds | go90 | 2017 | 1 | 6 | Comedy |
| Emerald City | NBC | 2017 | 1 | 10 | Fantasy |
| Emerald Point N.A.S. | CBS | 1983–1984 | 1 | 22 | Soap opera |
| Emergence | ABC | 2019–2020 | 1 | 13 | Drama |
| Emergency! | NBC | 1972–1977 | 6 | 123 | Drama |
| Emergency +4 | NBC | 1973–1974 | 2 | 23 | — |
| Emergency Vets | Animal Planet | 1998–2002 | — | — | Reality |
| Emeril | NBC | 2001 | 1 | 11 | — |
| The Emeril Lagasse Show | Ion Television | 2010 | — | — | Talk show |
| Emeril Live | Food Network | 1997–2010 | — | — | — |
| Emily in ParisWeb series | Netflix | 2020–on air | 5 | 50 | Comedy-drama |
| Emily Owens | The CW | 2012–2013 | 1 | 13 | LGBTQ |
| Emily's Reasons Why Not | ABC | 2006 | 1 | 7 | Sitcom |
| Emily's Wonder Lab | Netflix | 2020–on air | 1 | 10 | — |
| Emmet Otter's Jug-Band Christmas | HBO, CBC Television | 1977 | — | — | Christmas |
| An Emmy for MeganWeb series | | 2018–on air | 2 | 12 | Mockumentary |
| The Emperor's New SchoolAnimated series | ABC, Disney Channel | 2006–2008 | 2 | 52 | Children's |
| Empire | NBC | 1962–1963 | 1 | 32 | — |
| Empire | CBS | 1984 | 1 | 6 | — |
| Empire | ABC | 2005 | 1 | 6 | — |
| Empire | Fox | 2015–2020 | 6 | 102 | Drama |
| Empire FallsMiniseries | HBO | 2005 | 1 | 2 | Drama |
| Empire of Dreams | A&E | 2004 | — | — | Documentary |
| The Employables | A&E | 2019–on air | — | — | Documentary |
| Empty Nest | NBC | 1988–1995 | 7 | 170 | Sitcom |
| En otra piel | Telemundo | 2014 | 1 | 154 | Telenovela |
| Encore! | Disney+ | 2019–2020 | 1 | 12 | Documentary |
| Encore! Encore! | NBC | 1998–1999 | 1 | 13 | Sitcom |
| Encounters | Fox | 1994–1996 | 3 | 18 | — |
| Encounters | Netflix | 2023 | 1 | 4 | Documentary |
| The Endgame | NBC | 2022 | 1 | 10 | Drama |
| Endurance | Discovery Kids, NBC | 2002–2008 | 6 | 86 | Reality |
| The Enemy Within | NBC | 2019 | 1 | 13 | Drama |
| Engaged and Underage | MTV | 2007–2008 | 2 | 20 | Reality |
| Engineering an Empire | History | 2005–2006 | 1 | 14 | Documentary |
| The English | Prime Video, BBC One | 2022 | — | 6 | Western |
| English Teacher | FX | 2024–2025 | 2 | 18 | — |
| Enlightened | HBO | 2011–2013 | 2 | 18 | Comedy-drama |
| Enlisted | Fox | 2014 | 1 | 13 | Comedy |
| Enos | CBS | 1980–1981 | 1 | 18 | Comedy-drama |
| Ensign O'Toole | NBC | 1962–1963 | 1 | 32 | Comedy |
| The Entertainers | CBS | 1964–1965 | 1 | 26 | Variety show |
| Entertainment News TelevisionNews program | Syndication | 1994–2020 | 23 | 6,329 | Wide show |
| Entertainment Tonight | Syndication | 1981 | 36 | 10,415 | Entertainment journalism |
| Entourage | HBO | 2004–2011 | 8 | 96 | LGBTQ |
| Epic Ink | A&E | 2014 | 1 | 10 | Documentary |
| Epic Rap Battles of HistoryWeb series | YouTube | 2010 | 6 | 73 | Battle rap |
| The Epic Tales of Captain UnderpantsAnimated series | Netflix | 2018–2020 | 4 | 45 | Action |
| The Epic Tales of Captain Underpants in Space!Animated series | Netflix | 2020–on air | 1 | 6 | — |
| Episodes | Showtime, BBC Two | 2011–2017 | 5 | 41 | LGBTQ |
| Epithet ErasedAnimated series | VRV | 2019–on air | 1 | 7 | Action comedy |
| Equal Justice | ABC | 1990–1991 | 2 | 26 | Drama |
| Equal Justice With Judge Eboni K. Williams | Syndication | 2023–on air | 3 | 245 | — |
| The Equalizer | CBS | 1985–1989 | 4 | 88 | Crime |
| The Equalizer | CBS | 2021–2025 | 5 | 74 | Crime |
| ER | NBC | 1994–2009 | 15 | 331 | Medical drama |
| Eric & Jessie | E! | 2013–2017 | 2 | 12 | Reality |
| The Eric Andre Show | Cartoon Network, Adult Swim | 2012 | 4 | 40 | Comedy |
| Erin & Aaron | TeenNick, Nickelodeon | 2023–on air | 1 | 13 | Musical |
| The Ernie Kovacs Show | NBC | 1953–1961 | — | — | Comedy |
| Erotic Confessions | Cinemax | 1992–1996 | 6 | 59 | LGBTQ |
| Escape | NBC | 1973 | 1 | 4 | Anthology |
| Escape at DannemoraMiniseries | Showtime | 2018 | 1 | 7 | Drama |
| Escape Club | E! | 2014 | 1 | 8 | Reality |
| Escape Routes | NBC | 2012 | 1 | 6 | Reality |
| Escape the NightWeb series | YouTube Premium | 2016–2019 | 2 | 19 | Mystery |
| Escape to Chimp Eden | Animal Planet | 2008 | 2 | 32 | Nature documentary |
| Esme & RoyAnimated series | HBO Max, PBS Kids | 2018–2021 | 2 | 52 | Children's |
| Espionage | NBC | 1963–1964 | 1 | 24 | Anthology |
| ESPN First TakeNews program | ESPN, ESPN2 | 2007 | — | — | — |
| ESPN Jeopardy! | ESPN, Hulu | 2026–on air | — | — | Game show |
| ESPN SportsCenter | ESPN, ESPN2 | 1979 | 38 | — | — |
| Essence of Emeril | Food Network | 1994–2007 | — | — | Cooking show |
| Estate of Panic | Syfy | 2008 | 1 | 6 | Reality |
| Estocolmo | Netflix | 2016 | 1 | 13 | — |
| Eternally Yours | Paramount+, CBS | 2026–on air | 1 | 20 | Sitcom |
| Ethel Barrymore Theatre | DuMont | 1956 | 1 | 14 | — |
| Étoile | Prime Video | 2025 | 1 | 8 | Comedy |
| Euphoria | HBO | 2019–on air | 3 | 26 | LGBTQ |
| Eureeka's Castle | Nickelodeon | 1989–1991 | 6 | 148 | Fantasy |
| Eureka | Syfy | 2006–2012 | 5 | 77 | Science fiction |
| Eva la Trailera | Telemundo | 2016 | — | 118 | Telenovela |
| Eva Luna | Univision | 2010–2011 | 1 | 112 | Telenovela |
| Eve | UPN | 2003–2006 | 3 | 66 | Sitcom |
| Even Stevens | Disney Channel | 2000–2003 | 3 | 65 | Teen sitcom |
| Evening Magazine | Syndication | 1976–1991 | 16 | 2,652 | — |
| Evening Shade | CBS | 1990–1994 | 4 | 98 | Comedy |
| The Event | NBC | 2010–2011 | 1 | 22 | Science fiction |
| Everest: Beyond the Limit | Discovery Channel | 2006–2009 | 3 | 19 | Reality |
| The Everglades | Syndication | 1961–1962 | 1 | 38 | — |
| Everwood | The WB | 2002–2006 | 4 | 89 | Drama |
| Every Witch Way | Nickelodeon | 2014–2015 | 4 | 88 | Fantasy |
| Every Year After | Prime Video | 2026–on air | 1 | 8 | Romantic |
| Everybody Hates Chris | UPN | 2005–2009 | 4 | 88 | Sitcom |
| Everybody Loves Natti | Prime Video | 2021–on air | 1 | 6 | Documentary |
| Everybody Loves Raymond | CBS | 1996–2005 | 9 | 210 | Sitcom |
| Everybody Still Hates ChrisAnimated series | Paramount+ | 2024–on air | — | — | Adult animation |
| Everything's Relative | CBS | 1987 | 1 | 10 | Sitcom |
| Everything's Relative | NBC | 1999 | 1 | 4 | Sitcom |
| Everything's Trash | Freeform | 2022 | 1 | 10 | Comedy |
| Everything Sucks! | Netflix | 2018 | 1 | 10 | Comedy-drama |
| Everything’s Gonna Be Okay | Freeform | 2020–2021 | 2 | 20 | Comedy |
| The Evidence | ABC | 2006 | 1 | 8 | Drama |
| Evil | CBS, Paramount+ | 2019–2024 | 4 | 50 | Thriller |
| Evil Con CarneAnimated series | Cartoon Network | 2003–2004 | 2 | 14 | Science fiction comedy |
| Evil Genius: The True Story of America's Most Diabolical Bank HeistMiniseries | Netflix | 2018 | 1 | 4 | Documentary |
| Evil Kin | Investigation Discovery | 2013 | 3 | 25 | Documentary |
| Evil Lives Here | Investigation Discovery | 2016 | 3 | 28 | Documentary |
| Evita PeronMiniseries | NBC | 1981 | — | 2 | Biographical |
| EwoksAnimated series | ABC | 1985–1986 | 2 | 35 | Fantasy |
| The Ex List | CBS | 2008 | 1 | 13 | Fantasy |
| Ex-treme Dating | Syndication | 2002–2004 | 2 | 19 | Reality |
| The Ex-Wives Club | ABC, RTL 5 | 2007 | — | 5 | Reality |
| Exandria UnlimitedWeb series | YouTube, Twitch | 2021–2022 | 3 | 18 | Fantasy |
| Executive Suite | CBS | 1976–1977 | 1 | 18 | Drama |
| The Exes | TV Land | 2011–2015 | 4 | 64 | Sitcom |
| The Exile | CBS | 1991 | 1 | 13 | Action |
| Exit 57 | Comedy Central | 1995–1996 | — | 12 | — |
| The Exorcist | Fox | 2016–2017 | 2 | 20 | Drama |
| ExosquadAnimated series | Syndication | 1993–1994 | 2 | 52 | Science fiction |
| The Expanse | Prime Video, Syfy | 2015–2022 | 6 | 62 | Drama |
| ExpatsMiniseries | Prime Video | 2024 | 1 | 6 | Drama |
| Expedition! | ABC | 1960–1962 | 2 | 48 | Documentary |
| Expedition Africa | History | 2009 | 1 | 8 | Reality |
| Expedition Unknown | Discovery Channel, Travel Channel | 2015 | 2 | 35 | Documentary |
| Explained | Netflix | 2018–on air | 3 | 34 | Documentary |
| Exposed | MTV | 2007–2008 | 2 | 40 | Reality |
| Exposure | Syfy | 2000–2002 | — | — | — |
| Extant | CBS | 2014–2015 | 2 | 26 | Science fiction |
| Extended Family | NBC | 2023–2024 | 1 | 13 | Sitcom |
| Exterminate All the BrutesMiniseries | HBO | 2021 | 1 | 4 | Documentary |
| Extinct | BYUtv | 2017 | 1 | 10 | Post-apocalyptic |
| Extinct or Alive | Animal Planet | 2018–2021 | 2 | 18 | — |
| Extracted | Fox | 2025–on air | 1 | 10 | Reality competition |
| Extralarge | Rai 2 | 1991–1993 | 2 | 12 | Action |
| Extrapolations | Apple TV | 2023 | 1 | 8 | Dystopian |
| Extraterrestrial | Channel 4 | 2005 | 1 | 2 | — |
| Extreme | ABC | 1995 | 1 | 7 | — |
| Extreme Cheapskates | TLC | 2012–2014 | 3 | 26 | Reality |
| Extreme Clutter with Peter Walsh | OWN | 2011–2012 | 2 | 13 | Reality |
| Extreme Cougar Wives | TLC | 2012–2013 | 1 | 3 | Reality |
| Extreme Couponing | TLC | 2010–2012 | 5 | 41 | Reality |
| Extreme DinosaursAnimated series | Syndication | 1997 | 1 | 52 | Action |
| Extreme Dodgeball | Game Show Network | 2004–2005 | 3 | 38 | — |
| Extreme Engineering | Discovery Channel | 2003–2011 | 9 | 77 | Documentary |
| Extreme GhostbustersAnimated series | Syndication | 1997 | 1 | 40 | Science fiction |
| Extreme Makeover | ABC | 2002–2007 | 4 | 54 | Docu-soap |
| Extreme Makeover: Home Edition | ABC | 2003–2012 | 9 | 200 | Reality |
| Extreme Makeover: Home Edition: How'd They Do That? | ABC | 2004–2005 | 1 | 17 | Reality |
| Extreme Makeover: Weight Loss Edition | ABC | 2011–2015 | 4 | 41 | Reality |
| Extreme Trains | History | 2008 | 1 | 8 | — |
| Eye Candy | MTV | 2015 | 1 | 10 | Thriller |
| Eye for an Eye | Syndication | 2003–2009 | 5 | — | — |
| Eye Guess | NBC | 1966–1969 | 4 | — | — |
| Eye Opener | Syndication | 2011–2017 | 4 | — | Breakfast |
| Eye to Eye | ABC | 1985 | 1 | 7 | — |
| Eye Witness | NBC | 1953 | 1 | 13 | — |
| Eyes | ABC | 2005 | 1 | 12 | Drama |
| Eyes of WakandaAnimated series | Disney+ | 2025–on air | 1 | 4 | Drama |
| Eyes on the Prize | PBS | 1987–1990 | 2 | 14 | Documentary |
| Eyewitness | USA Network | 2016 | 1 | 10 | Drama |
| EZ Streets | CBS | 1996–1997 | 1 | 9 | Drama |