| MTV Entertainment Studios Presents: Ren & StimpyAnimated series | 2024–on air | 1 | 10 | Surreal humour | |
| FairviewAnimated series | 2022–on air | 1 | 8 | Adult animation | |
| Tyler Perry's Young Dylan | 2020–2025 | 5 | 85 | Sitcom | Tyler Perry |
| Alternatino with Arturo Castro | 2019–on air | — | — | Variety show | |
| Historical Roasts | 2019–on air | 1 | 6 | Alternate history | Jeff Ross |
| Lights Out with David Spade | 2019–2020 | — | — | — | David Spade |
| South Side | 2019–2022 | — | — | Sitcom | Bashir Salahuddin |
| The Other Two | 2019–on air | 3 | 30 | LGBTQ | Chris Kelly, Sarah Schneider |
| Corporate | 2018–2020 | 2 | 20 | Black comedy | Matt Ingebretson, Jake Weisman |
| Taskmaster | 2018 | 1 | 8 | Panel game | Alex Horne |
| Detroiters | 2017–2018 | 2 | 20 | — | |
| Jeff & Some Aliens | 2017 | 1 | 7 | Comedy | |
| The Jim Jefferies Show | 2017–2019 | 1 | 4 | Late-night talk show | |
| The Opposition with Jordan Klepper | 2017–2018 | 1 | 128 | — | |
| The President Show | 2017 | 1 | 7 | Satire | Anthony Atamanuik |
| Idiotsitter | 2016–2017 | — | 10 | Sitcom | Jillian Bell, Charlotte Newhouse |
| Legends of Chamberlain Heights | 2016–2017 | 1 | 20 | — | |
| Not Safe with Nikki Glaser | 2016 | 1 | 10 | Talk show | |
| Time Traveling BongMiniseries | 2016 | — | 3 | — | |
| Typical Rick | 2016–2017 | — | — | — | |
| Another Period | 2015–2018 | 3 | 32 | LGBTQ | |
| Big Time in Hollywood, FL | 2015 | 1 | 10 | Comedy | |
| Moonbeam CityAnimated series | 2015 | 1 | 10 | Animated sitcom | |
| The Nightly Show with Larry Wilmore | 2015–2016 | 2 | 259 | — | |
| Why? with Hannibal Buress | 2015 | 1 | 8 | — | |
| Broad City | 2014–2019 | 5 | 50 | Sitcom | Ilana Glazer, Abbi Jacobson |
| Comedy Underground with Dave Attell | 2014 | 1 | 8 | — | |
| Review | 2014–2017 | 3 | 22 | Comedy | Andrew Daly |
| The Meltdown with Jonah and Kumail | 2014–2016 | 2 | 16 | — | |
| TripTankAnimated series | 2014–2016 | 2 | 18 | Adult animation | |
| @midnight | 2013–2017 | 3 | 600 | Improvisational theatre | |
| Adam DeVine's House Party | 2013–2016 | 3 | 24 | — | |
| Brody Stevens: Enjoy It! | 2013–2014 | 1 | 12 | — | |
| Drunk History | 2013–2019 | 6 | 87 | Comedy | |
| Inside Amy Schumer | 2013–2016 | 5 | 44 | Sketch comedy | Amy Schumer |
| Kroll Show | 2013–2015 | 3 | 30 | Comedy | |
| Nathan for You | 2013–2017 | 4 | 31 | Comedy | Nathan Fielder |
| The Ben Show | 2013 | 1 | 8 | Comedy | Ben Hoffman |
| The Jeselnik Offensive | 2013 | 2 | 18 | — | Anthony Jeselnik |
| BrickleberryAnimated series | 2012–2015 | 3 | 36 | Comedy | |
| Key & Peele | 2012–2015 | 5 | 53 | German television comedy | Keegan-Michael Key, Jordan Peele |
| Reality Show | 2012 | 1 | 10 | Comedy | Adam Rifkin |
| The Burn with Jeff Ross | 2012–2013 | 2 | 12 | Comedy | Jeff Ross |
| Gabriel Iglesias Presents Stand Up Revolution | 2011–2014 | 3 | 19 | — | |
| Jon Benjamin Has a Van | 2011 | 1 | 10 | Comedy | H. Jon Benjamin |
| Onion SportsDome | 2011 | 1 | 10 | — | |
| Sports Show with Norm Macdonald | 2011 | 1 | 9 | Comedy | Norm Macdonald |
| Workaholics | 2011–2017 | 7 | 86 | Sitcom | Blake Anderson |
| Big Lake | 2010 | 1 | 10 | Sitcom | |
| John Oliver's New York Stand-Up Show | 2010–2013 | 4 | 26 | Comedy | |
| Nick Swardson's Pretend Time | 2010–2011 | 2 | 14 | — | Nick Swardson |
| The Benson Interruption | 2010 | 1 | 6 | — | |
| Ugly AmericansAnimated series | 2010–2012 | 2 | 31 | Sitcom | David M. Stern |
| Important Things with Demetri Martin | 2009–2010 | 2 | 17 | — | Demetri Martin |
| Michael & Michael Have Issues | 2009 | 1 | 7 | — | Michael Ian Black |
| Secret Girlfriend | 2009 | 1 | 6 | — | |
| The Jeff Dunham Show | 2009 | 1 | 7 | Sketch comedy | Jeff Dunham |
| Tosh.0 | 2009–2020 | 8 | 211 | Comedy | |
| Atom TV | 2008–2010 | 3 | 36 | — | |
| Chocolate News | 2008 | 1 | 10 | — | |
| Lewis Black's Root of All Evil | 2008 | 2 | 18 | Comedy | |
| Reality Bites Back | 2008 | 1 | 8 | Comedy | |
| The Gong Show with Dave Attell | 2008 | 1 | 8 | — | Chris Bearde |
| American Body Shop | 2007 | 1 | 10 | — | |
| Halfway Home | 2007 | 1 | 10 | — | Oscar Nunez |
| Lil' BushAnimated series | 2007–2008 | 2 | 17 | Adult animation | Donick Cary |
| The Sarah Silverman Program | 2007–2010 | 3 | 32 | LGBTQ | Sarah Silverman |
| Dog Bites Man | 2006 | 1 | 10 | — | Dan Mazer |
| Freak ShowAnimated series | 2006 | 1 | 7 | Adult animation | H. Jon Benjamin, David Cross |
| Live at Gotham | 2006–2009 | — | — | Comedy | |
| Con | 2005 | 1 | 6 | — | |
| Mind of Mencia | 2005–2008 | 4 | 52 | Comedy | Carlos Mencia |
| Stella | 2005 | 1 | 10 | — | Michael Ian Black |
| The Colbert ReportNews program | 2005–2014 | 10 | 1,447 | Comedy | Jon Stewart, Stephen Colbert |
| The Showbiz Show with David Spade | 2005–2007 | 3 | 39 | — | |
| Too Late with Adam Carolla | 2005 | 1 | 50 | — | Adam Carolla |
| Crossballs: The Debate Show | 2004 | 1 | 24 | — | Matt Besser |
| Drawn TogetherAnimated series | 2004–2007 | 3 | 36 | LGBTQ | Dave Jeser & Matt Silverstein |
| Drew Carey's Green Screen Show | 2004–2005 | — | 13 | Comedy | Drew Carey |
| Shorties Watchin' ShortiesAnimated series | 2004 | — | 13 | Comedy | Jim Serpico |
| The Graham Norton Effect | 2004 | 1 | 13 | Comedy | |
| Wanda Does It | 2004 | 1 | 6 | — | |
| Chappelle's Show | 2003–2006 | 3 | 33 | Comedy | Dave Chappelle, Neal Brennan |
| Comedy Central Roast | 2003–2019 | — | 14 | Roast | |
| Gerhard Reinke's Wanderlust | 2003 | — | 6 | Comedy | Josh Gardner |
| I'm with Busey | 2003 | 1 | 13 | — | |
| Kid NotoriousAnimated series | 2003 | 2 | 9 | Adult animation | Brett Morgen |
| Reno 911! | 2003–2009 | 8 | 113 | Mockumentary | Thomas Lennon, Kerri Kenney |
| Contest Searchlight | 2002 | 1 | 4 | — | Jim Serpico |
| Crank Yankers | 2002 | 4 | 70 | Sitcom | Adam Carolla |
| Tough Crowd with Colin Quinn | 2002–2004 | — | 200 | — | Colin Quinn |
| Beat the Geeks | 2001–2002 | 2 | 130 | Game show | Mark Cronin |
| Insomniac with Dave Attell | 2001–2004 | 4 | 45 | — | Dave Attell |
| Let's Bowl | 2001–2002 | 1 | 20 | — | Tim Scott |
| Primetime Glick | 2001–2003 | 3 | 30 | — | |
| That's My Bush! | 2001 | 1 | 8 | Sitcom | Trey Parker |
| BattleBots | 2000 | 12 | 152 | Robot competition | |
| Strip Mall | 2000–2001 | 2 | 20 | Sitcom | Julie Brown |
| TV FunhouseAnimated series | 2000–2001 | 1 | 8 | — | Robert Smigel |
| Frank Leaves for the Orient | 1999 | 1 | 6 | — | |
| FuturamaAnimated series | 1999–2025 | 11 | 151 | Comedy | Matt Groening, David X. Cohen |
| Strangers with Candy | 1999–2000 | 3 | 30 | Black comedy | Stephen Colbert |
| The Man Show | 1999–2004 | 6 | 112 | — | |
| Comedy Central Presents | 1998–2011 | 15 | 283 | Stand-up comedy | |
| Upright Citizens Brigade | 1998–2000 | 3 | 30 | — | |
| Premium Blend | 1997–2005 | 9 | 90 | Stand-up comedy | |
| South ParkAnimated series | 1997 | 29 | 344 | Surreal humour | Trey Parker, Matt Stone |
| Viva Variety | 1997–1999 | — | — | Sketch comedy | Ben Garant |
| Win Ben Stein's Money | 1997–2003 | 6 | 715 | Game show | |
| Pulp Comics | 1996–2000 | — | 15 | Comedy | |
| The Daily Show | 1996 | 31 | 4,214 | Political satire | Madeleine Smithberg, Lizz Winstead |
| Dr. Katz, Professional TherapistAnimated series | 1995–1999 | 6 | 86 | Adult animation | Jonathan Katz, Tom Snyder |
| Exit 57 | 1995–1996 | — | 12 | — | Amy Sedaris |
| Viva Vietnam: A White Trash Adventure Tour | 1995 | — | — | Documentary | Tom Rhodes |
| Politically Incorrect | 1993–2002 | 8 | 2,267 | Talk show | |
