| Jan 8 | John Oliver's New York Stand-Up Show | 2010–2013 | 4 | 26 | Comedy | |
| Mar 17 | Ugly AmericansAnimated series | 2010–2012 | 2 | 31 | Sitcom | David M. Stern |
| Aug 17 | Big Lake | 2010 | 1 | 10 | Sitcom | |
| Oct 12 | Nick Swardson's Pretend Time | 2010–2011 | 2 | 14 | — | Nick Swardson |
| Nov 5 | The Benson Interruption | 2010 | 1 | 6 | — | |
| Jan 11 | Onion SportsDome | 2011 | 1 | 10 | — | |
| Apr 6 | Workaholics | 2011–2017 | 7 | 86 | Sitcom | Blake Anderson |
| Apr 12 | Sports Show with Norm Macdonald | 2011 | 1 | 9 | Comedy | Norm Macdonald |
| Jun 14 | Jon Benjamin Has a Van | 2011 | 1 | 10 | Comedy | H. Jon Benjamin |
| Oct 6 | Gabriel Iglesias Presents Stand Up Revolution | 2011–2014 | 3 | 19 | — | |
| Jan 31 | Key & Peele | 2012–2015 | 5 | 53 | German television comedy | Keegan-Michael Key, Jordan Peele |
| Aug 14 | The Burn with Jeff Ross | 2012–2013 | 2 | 12 | Comedy | Jeff Ross |
| Sep 25 | BrickleberryAnimated series | 2012–2015 | 3 | 36 | Comedy | |
| Nov 1 | Reality Show | 2012 | 1 | 10 | Comedy | Adam Rifkin |
| Jan 16 | Kroll Show | 2013–2015 | 3 | 30 | Comedy | |
| Feb 19 | The Jeselnik Offensive | 2013 | 2 | 18 | — | Anthony Jeselnik |
| Feb 28 | Nathan for You | 2013–2017 | 4 | 31 | Comedy | Nathan Fielder |
| Feb 28 | The Ben Show | 2013 | 1 | 8 | Comedy | Ben Hoffman |
| Apr 30 | Inside Amy Schumer | 2013–2016 | 5 | 44 | Sketch comedy | Amy Schumer |
| Jul 9 | Drunk History | 2013–2019 | 6 | 87 | Comedy | |
| Oct 21 | @midnight | 2013–2017 | 3 | 600 | Improvisational theatre | |
| Oct 24 | Adam DeVine's House Party | 2013–2016 | 3 | 24 | — | |
| Dec 2 | Brody Stevens: Enjoy It! | 2013–2014 | 1 | 12 | — | |
| Jan 22 | Broad City | 2014–2019 | 5 | 50 | Sitcom | Ilana Glazer, Abbi Jacobson |
| Mar 6 | Review | 2014–2017 | 3 | 22 | Comedy | Andrew Daly |
| Apr 2 | TripTankAnimated series | 2014–2016 | 2 | 18 | Adult animation | |
| Apr 12 | Comedy Underground with Dave Attell | 2014 | 1 | 8 | — | |
| Jul 24 | The Meltdown with Jonah and Kumail | 2014–2016 | 2 | 16 | — | |
| Jan 19 | The Nightly Show with Larry Wilmore | 2015–2016 | 2 | 259 | — | |
| Mar 25 | Big Time in Hollywood, FL | 2015 | 1 | 10 | Comedy | |
| Jun 23 | Another Period | 2015–2018 | 3 | 32 | LGBTQ | |
| Jul 8 | Why? with Hannibal Buress | 2015 | 1 | 8 | — | |
| Sep 16 | Moonbeam CityAnimated series | 2015 | 1 | 10 | Animated sitcom | |
| Jan 14 | Idiotsitter | 2016–2017 | — | 10 | Sitcom | Jillian Bell, Charlotte Newhouse |
| Feb 9 | Not Safe with Nikki Glaser | 2016 | 1 | 10 | Talk show | |
| Apr 20 | Time Traveling BongMiniseries | 2016 | — | 3 | — | |
| Sep 14 | Legends of Chamberlain Heights | 2016–2017 | 1 | 20 | — | |
| Nov 14 | Typical Rick | 2016–2017 | — | — | — | |
| Jan 11 | Jeff & Some Aliens | 2017 | 1 | 7 | Comedy | |
| Feb 7 | Detroiters | 2017–2018 | 2 | 20 | — | |
| Apr 27 | The President Show | 2017 | 1 | 7 | Satire | Anthony Atamanuik |
| Jun 6 | The Jim Jefferies Show | 2017–2019 | 1 | 4 | Late-night talk show | |
| Sep 25 | The Opposition with Jordan Klepper | 2017–2018 | 1 | 128 | — | |
| Jan 17 | Corporate | 2018–2020 | 2 | 20 | Black comedy | Matt Ingebretson, Jake Weisman |
| Apr 27 | Taskmaster | 2018 | 1 | 8 | Panel game | Alex Horne |
| — | Historical Roasts | 2019–on air | 1 | 6 | Alternate history | Jeff Ross |
| Jan 24 | The Other Two | 2019–on air | 3 | 30 | LGBTQ | Chris Kelly, Sarah Schneider |
| Jun 18 | Alternatino with Arturo Castro | 2019–on air | — | — | Variety show | |
| Jul 24 | South Side | 2019–2022 | — | — | Sitcom | Bashir Salahuddin |
| Jul 29 | Lights Out with David Spade | 2019–2020 | — | — | — | David Spade |