| President CurtisAnimated series | 2026–on air | — | — | Adult animation | Dan Harmon |
| Common Side EffectsAnimated series | 2025–on air | 1 | 10 | Adult animation | Joseph Bennett, Steve Hely |
| Haha, You ClownsAnimated series | 2025–on air | — | — | Animated sitcom | Joe Cappa |
| Royal CrackersAnimated series | 2023–on air | 2 | 20 | Animated sitcom | Jason Ruiz |
| Unicorn: Warriors Eternal | 2023–on air | 1 | 3 | Steampunk | Genndy Tartakovsky |
| Aqua DonkWeb series | 2022 | 1 | 10 | Comedy | |
| Smiling FriendsAnimated series | 2022–2026 | 3 | 27 | Animated sitcom | Zach Hadel, Michael Cusack |
| BirdgirlAnimated series | 2021–on air | 2 | 12 | Adult animation | Michael Ouweleen, Erik Richter |
| Beef House | 2020–on air | — | 6 | Sitcom | Tim Heidecker, Eric Wareheim |
| Three Busy Debras | 2020–2022 | — | 16 | Comedy | Mitra Jouhari |
| Gemusetto Machu PicchuAnimated series | 2019–2020 | 2 | 20 | Comedy | Max Simonet |
| Infinity TrainAnimated series | 2019–2021 | 4 | 40 | Fantasy | Owen Dennis |
| Lazor WulfAnimated series | 2019–2021 | — | — | Comedy | |
| PrimalAnimated series | 2019–on air | 3 | 20 | Adult animation | Genndy Tartakovsky |
| Ballmastrz: 9009Animated series | 2018–2023 | 2 | 20 | Adult animation | Christy Karacas |
| Final SpaceAnimated series | 2018–2021 | 3 | 36 | Science fantasy | Olan Rogers |
| Hot StreetsAnimated series | 2018–2019 | — | 4 | — | |
| Joe Pera Talks with You | 2018–2021 | 2 | 20 | Comedy | Joe Pera |
| Mostly 4 Millennials | 2018 | — | 2 | Comedy | |
| Apollo GauntletAnimated series | 2017 | 1 | 6 | Comedy | |
| Samurai JackAnimated series | 2017 | 5 | 10 | Fantasy | Genndy Tartakovsky |
| Tender TouchesAnimated series | 2017–2018 | 1 | 5 | Adult animation | |
| The Jellies!Animated series | 2017–2019 | 1 | 1 | — | |
| Brad Neely's Harg Nallin' Sclopio PeepioAnimated series | 2016 | 1 | 10 | Sketch | Brad Neely |
| Dream Corp, LLC | 2016–2020 | 1 | 6 | Comedy | |
| Million Dollar Extreme Presents: World Peace | 2016 | 1 | 6 | Post-apocalyptic | |
| Neon Joe, Werewolf Hunter | 2015–2017 | 1 | 5 | — | |
| The Jack and Triumph Show | 2015 | 1 | 7 | — | |
| Black Jesus | 2014–2019 | 3 | 31 | Sitcom | |
| Decker | 2014–2020 | 1 | 6 | Sitcom | |
| Mike Tyson MysteriesAnimated series | 2014–2020 | 2 | 30 | Comedy | |
| Mr. PicklesAnimated series | 2014–2019 | 3 | 20 | Comedy | |
| Tim & Eric's Bedtime Stories | 2014–2017 | 2 | 13 | Anthology | |
| Hot Package | 2013–2015 | 2 | 9 | — | |
| King Star KingAnimated series | 2013–2014 | — | 6 | Adult animation | |
| Newsreaders | 2013–2015 | 2 | 24 | Comedy | Rob Corddry |
| Rick and MortyAnimated series | 2013 | 8 | 71 | Black comedy | Dan Harmon, Justin Roiland |
| Your Pretty Face Is Going to Hell | 2013–2019 | 4 | 42 | Comedy | |
| Loiter Squad | 2012–2014 | 2 | 21 | — | |
| The Eric Andre Show | 2012 | 4 | 40 | Comedy | Eric André |
| The Greatest Event in Television History | 2012–2014 | 1 | 4 | Mockumentary | Adam Scott |
| The High Fructose Adventures of the Annoying Orange | 2012–2014 | 2 | 52 | Live action & animation | |
| You're Whole | 2012–2013 | 2 | 8 | Comedy | |
| China, ILAnimated series | 2011–2015 | 3 | 30 | College life | |
| Eagleheart | 2011–2014 | 3 | 34 | Comedy | |
| Mongo Wrestling AllianceAnimated series | 2011 | 1 | 10 | Adult animation | |
| NTSF:SD:SUV:: | 2011–2013 | 3 | 39 | Black comedy | |
| Off the Air | 2011 | 5 | 27 | Anthology | Dave Hughes |
| Soul Quest OverdriveAnimated series | 2011 | 1 | 4 | Adult animation | Matt Maiellaro, Dave Willis |
| The Heart, She Holler | 2011–2014 | 3 | 28 | Black comedy | Vernon Chatman, John Lee |
| Check It Out! with Dr. Steve Brule | 2010–2016 | 4 | 24 | — | |
| Mary Shelley's FrankenholeAnimated series | 2010–2012 | 2 | 20 | Comedy | Dino Stamatopoulos |
| Tower Prep | 2010 | 1 | 13 | Teen drama | Paul Dini |
| G.I. Joe: Resolute | 2009 | 1 | 11 | — | |
| InfomercialsWeb series | 2009 | 2 | 15 | Short | |
| The Rising Son | 2009 | 1 | 4 | — | |
| Titan MaximumAnimated series | 2009 | — | 72 | — | Matthew Senreich |
| Childrens Hospital | 2008 | — | 86 | Satire | Rob Corddry |
| Delocated | 2008–2013 | 3 | 30 | Comedy | Jon Glaser |
| Fat Guy Stuck in Internet | 2008 | 1 | 10 | Science fiction | John Gemberling |
| The Drinky Crow ShowAnimated series | 2008–2009 | 1 | 10 | Comedy | Tony Millionaire |
| Out of Jimmy's Head | 2007 | 1 | 20 | Comedy | |
| Saul of the Mole Men | 2007 | 1 | 20 | Comedy | |
| Superjail!Animated series | 2007–2014 | 4 | 36 | Adult animation | |
| Tim and Eric Awesome Show, Great Job! | 2007–2010 | 5 | 50 | Sketch comedy | Tim Heidecker |
| Xavier: Renegade AngelAnimated series | 2007–2009 | 2 | 20 | Adult animation | Vernon Chatman, John Lee |
| Assy McGeeAnimated series | 2006–2008 | 2 | 20 | Detective | Matt Harrigan |
| Frisky DingoAnimated series | 2006–2008 | 2 | 25 | Satire | Adam Reed |
| MetalocalypseAnimated series | 2006–2013 | 4 | 63 | Music | Tommy Blacha, Brendon Small |
| MinoriteamAnimated series | 2006 | 1 | 19 | Adult animation | |
| 12 oz. MouseAnimated series | 2005–2018 | 3 | 22 | Exploitation | Matt Maiellaro |
| Lucy, the Daughter of the DevilAnimated series | 2005–2007 | 1 | 11 | Adult animation | Loren Bouchard |
| Moral OrelAnimated series | 2005–2008 | 3 | 43 | Comedy | Dino Stamatopoulos |
| Robot ChickenAnimated series | 2005 | 11 | 227 | Adult animation | Seth Green, Matthew Senreich |
| SquidbilliesAnimated series | 2005–2016 | 13 | 110 | Comedy | Dave Willis |
| The BoondocksAnimated series | 2005–2014 | 4 | 55 | Comedy | Aaron McGruder |
| Perfect Hair ForeverAnimated series | 2004–2014 | 3 | 9 | Comedy | Mike Lazzo, Matt Harrigan |
| Stroker and HoopAnimated series | 2004–2005 | 1 | 13 | Comedy | |
| Tom Goes to the MayorAnimated series | 2004–2006 | 2 | 31 | Adult animation | Tim Heidecker |
| The Venture Bros.Animated series | 2003–2018 | 7 | 81 | Comedy | Doc Hammer, Christopher McCulloch |
| Captain LingerWeb series | 2001 | 1 | 8 | Superhero | |
| UndergradsAnimated series | 2001 | 1 | 13 | College life | |
| Aqua Teen Hunger ForceAnimated series | 2000–2015 | 12 | 139 | Comedy | Dave Willis |
| Harvey Birdman, Attorney at LawAnimated series | 2000–2007 | 4 | 39 | Legal drama | Michael Ouweleen |
| Sealab 2021Animated series | 2000–2005 | 4 | 52 | Sitcom | Adam Reed |
| Home MoviesAnimated series | 1999–2004 | 4 | 52 | Comedy | Loren Bouchard, Brendon Small |
| King of the HillAnimated series | 1997–2010 | 15 | 259 | Comedy | Greg Daniels, Mike Judge |
| Space Ghost Coast to CoastAnimated series | 1994–2008 | 11 | 113 | Talk show | Mike Lazzo |
