| May 16 | Check It Out! with Dr. Steve Brule | 2010–2016 | 4 | 24 | — | |
| Jun 27 | Mary Shelley's FrankenholeAnimated series | 2010–2012 | 2 | 20 | Comedy | Dino Stamatopoulos |
| Oct 16 | Tower Prep | 2010 | 1 | 13 | Teen drama | Paul Dini |
| Jan 1 | Off the Air | 2011 | 5 | 27 | Anthology | Dave Hughes |
| Jan 23 | Mongo Wrestling AllianceAnimated series | 2011 | 1 | 10 | Adult animation | |
| Feb 3 | Eagleheart | 2011–2014 | 3 | 34 | Comedy | |
| May 24 | Soul Quest OverdriveAnimated series | 2011 | 1 | 4 | Adult animation | Matt Maiellaro, Dave Willis |
| Jul 21 | NTSF:SD:SUV:: | 2011–2013 | 3 | 39 | Black comedy | |
| Oct 2 | China, ILAnimated series | 2011–2015 | 3 | 30 | College life | |
| Nov 6 | The Heart, She Holler | 2011–2014 | 3 | 28 | Black comedy | Vernon Chatman, John Lee |
| Mar 25 | Loiter Squad | 2012–2014 | 2 | 21 | — | |
| May 20 | The Eric Andre Show | 2012 | 4 | 40 | Comedy | Eric André |
| Jun 11 | The High Fructose Adventures of the Annoying Orange | 2012–2014 | 2 | 52 | Live action & animation | |
| Oct 12 | The Greatest Event in Television History | 2012–2014 | 1 | 4 | Mockumentary | Adam Scott |
| Nov 5 | You're Whole | 2012–2013 | 2 | 8 | Comedy | |
| Jan 17 | Newsreaders | 2013–2015 | 2 | 24 | Comedy | Rob Corddry |
| Apr 18 | Your Pretty Face Is Going to Hell | 2013–2019 | 4 | 42 | Comedy | |
| Oct 4 | Hot Package | 2013–2015 | 2 | 9 | — | |
| Nov 3 | King Star KingAnimated series | 2013–2014 | — | 6 | Adult animation | |
| Dec 2 | Rick and MortyAnimated series | 2013 | 8 | 71 | Black comedy | Dan Harmon, Justin Roiland |
| Jul 17 | Decker | 2014–2020 | 1 | 6 | Sitcom | |
| Aug 7 | Black Jesus | 2014–2019 | 3 | 31 | Sitcom | |
| Sep 18 | Tim & Eric's Bedtime Stories | 2014–2017 | 2 | 13 | Anthology | |
| Sep 21 | Mr. PicklesAnimated series | 2014–2019 | 3 | 20 | Comedy | |
| Oct 27 | Mike Tyson MysteriesAnimated series | 2014–2020 | 2 | 30 | Comedy | |
| Feb 20 | The Jack and Triumph Show | 2015 | 1 | 7 | — | |
| Dec 7 | Neon Joe, Werewolf Hunter | 2015–2017 | 1 | 5 | — | |
| Jul 10 | Brad Neely's Harg Nallin' Sclopio PeepioAnimated series | 2016 | 1 | 10 | Sketch | Brad Neely |
| Aug 5 | Million Dollar Extreme Presents: World Peace | 2016 | 1 | 6 | Post-apocalyptic | |
| Oct 23 | Dream Corp, LLC | 2016–2020 | 1 | 6 | Comedy | |
| — | Samurai JackAnimated series | 2017 | 5 | 10 | Fantasy | Genndy Tartakovsky |
| Jul 9 | Apollo GauntletAnimated series | 2017 | 1 | 6 | Comedy | |
| Oct 22 | The Jellies!Animated series | 2017–2019 | 1 | 1 | — | |
| Dec 18 | Tender TouchesAnimated series | 2017–2018 | 1 | 5 | Adult animation | |
| Jan 14 | Hot StreetsAnimated series | 2018–2019 | — | 4 | — | |
| Feb 26 | Final SpaceAnimated series | 2018–2021 | 3 | 36 | Science fantasy | Olan Rogers |
| Apr 9 | Ballmastrz: 9009Animated series | 2018–2023 | 2 | 20 | Adult animation | Christy Karacas |
| May 20 | Joe Pera Talks with You | 2018–2021 | 2 | 20 | Comedy | Joe Pera |
| Jul 2 | Mostly 4 Millennials | 2018 | — | 2 | Comedy | |
| Apr 1 | Gemusetto Machu PicchuAnimated series | 2019–2020 | 2 | 20 | Comedy | Max Simonet |
| Apr 7 | Lazor WulfAnimated series | 2019–2021 | — | — | Comedy | |
| Aug 5 | Infinity TrainAnimated series | 2019–2021 | 4 | 40 | Fantasy | Owen Dennis |
| Oct 7 | PrimalAnimated series | 2019–on air | 3 | 20 | Adult animation | Genndy Tartakovsky |