| 1 | General Hospital | ABC | 1963 | 64 | 16,230 | LGBTQ |
| 2 | Guiding Light | CBS | 1937–2009 | 72 | 15,762 | Soap opera |
| 3 | Days of Our Lives | NBC | 2004 | — | 15,609 | Soap opera |
| 4 | As the World Turns | CBS | 1956–2010 | 54 | 13,858 | Soap opera |
| 5 | The Young and the Restless | CBS | 1973 | 53 | 12,775 | Soap opera |
| 6 | Nightly Business Report | PBS, WPBT | 1979–2019 | 40 | 12,000 | News magazine |
| 7 | Inside EditionNews program | Syndication, KBS Prime | 1989 | 30 | 11,257 | Entertainment journalism |
| 8 | Inside Edition WeekendNews program | Syndication | 1989 | 34 | 11,257 | News magazine |
| 9 | One Life to Live | ABC | 1968–2013 | 45 | 11,136 | Soap opera |
| 10 | All My Children | ABC, The Online Network | 1970–2013 | 43 | 10,755 | LGBTQ |
| 11 | Entertainment Tonight | Syndication | 1981 | 36 | 10,415 | Entertainment journalism |
| 12 | J. P. Patches | KIRO-TV | 1958–1981 | 24 | 10,000 | — |
| 13 | The Bold and the Beautiful | CBS | 1987 | 40 | 9,898 | Soap opera |
| 14 | Search for Tomorrow | NBC, CBS | 1951–1986 | 35 | 9,130 | Soap opera |
| 15 | The Price Is RightGame show | CBS, Syndication | 1972 | 50 | 9,000 | Game show |
| 16 | Another World | NBC | 1964–1999 | 35 | 8,891 | Soap opera |
| 17 | Good Morning AmericaNews program | ABC | 1975 | 45 | 8,779 | News |
| 18 | Live with Kelly and Mark | Syndication, WABC-TV | 1983–1988 | — | 7,580 | Talk show |
| 19 | The Edge of Night | CBS | 1956–1984 | 28 | 7,420 | Soap opera |
| 20 | Love of Life | CBS | 1951–1980 | 29 | 7,316 | Soap opera |
| 21 | Wheel of Fortune | NBC, CBS | 1983 | — | 7,100 | Game show |
| 22 | Entertainment News TelevisionNews program | Syndication | 1994–2020 | 23 | 6,329 | Wide show |
| 23 | Judge Judy | Syndication | 1996–2021 | 25 | 6,260 | Docu-soap |
| 24 | Larry King Live | CNN | 1985–2010 | — | 6,120 | News |
| 25 | Captain Kangaroo | CBS | 1955–1984 | 38 | 6,090 | Children's |
| 26 | The View | ABC | 1997 | 28 | 6,000 | Talk show |
| 27 | Divorce Court | Syndication | 1957 | 36 | 5,767 | — |
| 28 | The Phil Donahue Show | WDTN | 1967–1996 | — | 5,515 | Talk show |
| 29 | The Late Late Show | CBS | 1995–2023 | — | 5,346 | — |
| 30 | The O'Reilly Report | Fox News | 1996–2017 | 17 | 5,321 | Current affairs show |
| 31 | The Doctors | NBC | 1963–1982 | 20 | 5,280 | Soap opera |
| 32 | The Secret Storm | CBS | 1954–1974 | — | 5,195 | Soap opera |
| 33 | TodayNews program | NBC | 1952 | 68 | 5,081 | Talk show |
| 34 | The Merv Griffin Show | NBC | 1962–1986 | — | 4,855 | — |
| 35 | Sesame Street | HBO | 1969 | 56 | 4,744 | Educational |
| 36 | Laura | Telemundo, Las Estrellas | 1998–2015 | 18 | 4,680 | Talk show |
| 37 | The Tonight Show with Jay Leno | NBC | 1992–2014 | 22 | 4,610 | Humor |
| 38 | The Oprah Winfrey Show | CBS | 1986–2011 | 25 | 4,561 | Talk show |
| 39 | The Tonight Show Starring Johnny Carson | NBC | 1962–1992 | 30 | 4,531 | Late-night talk show |
| 40 | The Montel Williams Show | Syndication | 1991–2008 | 17 | 4,325 | Talk show |
| 41 | Late Show with David Letterman | CBS | 1993–2015 | 23 | 4,214 | Late-night talk show |
| 42 | The Daily Show | Comedy Central | 1996 | 31 | 4,214 | Political satire |
| 43 | NBC Nightly News with Tom LlamasNews program | NBC | 1948–1956 | — | 4,029 | News |
| 44 | The Mike Douglas Show | Syndication | 1961–1981 | 21 | 4,017 | — |
| 45 | The Jerry Springer Show | Syndication | 1991–2018 | 26 | 3,891 | Tabloid talk show |
| 46 | The Good Night Show | Universal Kids/MeTV Toons | 2005–2017 | 6 | 3,876 | — |
| 47 | Sally | KSDK | 1983 | 19 | 3,820 | Talk show |
| 48 | Classic Concentration | NBC | 1973–1991 | 15 | 3,770 | Game show |
| 49 | BET's 106 & Park | BET | 2000–2014 | — | 3,710 | Music |
| 50 | Jimmy Kimmel Live! | ABC | 2003 | 23 | 3,588 | Talk show |
| 51 | The Early ShowNews program | CBS | 1954–2012 | 13 | 3,578 | News |
| 52 | Hollywood Squares | NBC, CBS | 1983 | 26 | 3,536 | Quiz show |
| 53 | Ryan's Hope | ABC | 1975–1989 | 13 | 3,515 | Soap opera |
| 54 | Dr. Phil | CBS | 2002–2023 | 21 | 3,505 | Talk show |
| 55 | The Ellen DeGeneres Show | Syndication | 2003–2022 | 19 | 3,339 | Talk show |
| 56 | The InsiderNews program | Syndication, CBS | 2004–2017 | 11 | 3,221 | News magazine |
| 57 | Loving | ABC | 1983–1995 | 13 | 3,169 | Soap opera |
| 58 | CBS This MorningNews program | CBS | 1987–1996 | — | 3,100 | News |
| 59 | American Bandstand | ABC, Syndication | 1952–1989 | 37 | 3,000 | Music |
| 60 | The Talk | CBS | 2010–2024 | 15 | 2,993 | Talk show |
| 61 | Sábado Gigante | Univision, Canal 13 | 1962–2015 | 53 | 2,778 | — |
| 62 | Late Night with Conan O'Brien | NBC | 1993–2009 | 16 | 2,725 | Talk show |
| 63 | American MorningNews program | CNN | 2001–2011 | — | 2,688 | — |
| 64 | Evening Magazine | Syndication | 1976–1991 | 16 | 2,652 | — |
| 65 | Maury | | 1991–2022 | 31 | 2,640 | Tabloid talk show |
| 66 | CBS This Morning | CBS | 2012–2021 | — | 2,521 | Breakfast |
| 67 | Ricki Lake (1993 talk show) | Syndication | 1993–2004 | 11 | 2,420 | LGBTQ |
| 68 | Family Feud | CBS, ABC | 1976 | 19 | 2,384 | Game show |
| 69 | The Wendy Williams Show | Syndication | 2008–2022 | 7 | 2,332 | Talk show |
| 70 | 60 MinutesNews program | CBS | 1968 | 57 | 2,325 | Documentary |
| 71 | Politically Incorrect | Comedy Central, ABC | 1993–2002 | 8 | 2,267 | Talk show |
| 72 | The Price Is RightGame show | ABC, NBC | 1956–1965 | — | 2,263 | Game show |
| 73 | Total Request Live | MTV | 1998–2018 | 19 | 2,247 | Music chart |
| 74 | Passions | NBC | 1999–2008 | 9 | 2,231 | Fantasy |
| 75 | What's My Line? | CBS | 1950–1975 | 25 | 2,196 | Panel game |
| 76 | Good Morning America Weekend | ABC | 1993 | 17 | 2,172 | Breakfast |
| 77 | Hard Copy | Syndication | 1989–1999 | 9 | 2,159 | — |
| 78 | Santa Barbara | NBC | 1984–1993 | 9 | 2,137 | Soap opera |
| 79 | The Late Late Show with Craig Ferguson | CBS | 2005–2014 | 9 | 2,058 | Late-night talk show |
| 80 | I've Got a Secret | CBS | 2006 | — | 2,006 | Panel game |
| 81 | Washington Week with The Atlantic | PBS | 1967 | 50 | 2,000 | Public affairs |
| 82 | Judge Mathis | Syndication | 1999 | 18 | 2,000 | Court show |
| 83 | Last Call with Carson Daly | NBC | 2002–2019 | 17 | 2,000 | — |
| 84 | Tic-Tac-Dough | NBC, CBS | 1978 | 2 | 1,978 | Game show |
| 85 | Winner Take All | NBC, CBS | 1946–1952 | — | 1,952 | — |
| 86 | Red Eye | Fox News | 2007–2017 | — | 1,853 | Late-night talk show |
| 87 | Watch What Happens Live with Andy CohenTalk show | Bravo | 2009 | 17 | 1,843 | Late-night talk show |
| 88 | Yo! MTV Raps | MTV | 1988–1995 | — | 1,830 | Hip-hop |
| 89 | Anderson Cooper 360°News program | CNN | 2003 | — | 1,826 | News commentary podcast |
| 90 | Late Night with David Letterman | NBC | 1982–1993 | 11 | 1,819 | Late-night talk show |
| 91 | The Late Show with Stephen Colbert | CBS | 2015–2026 | 11 | 1,801 | Late-night talk show |
| 92 | Match Game | CBS, ABC | 1962–2021 | — | 1,760 | Panel game |
| 93 | WWE Raw | The National Network, WWE Network | 1993 | 31 | 1,723 | Professional wrestling |
| 94 | Somerset | NBC | 1970–1976 | 6 | 1,710 | Soap opera |
| 95 | The Dr. Oz Show | Syndication | 2009–2022 | 13 | 1,681 | Talk show |
| 96 | Late Night with Seth Meyers | NBC | 2014 | 12 | 1,635 | Late-night talk show |
| 97 | Port Charles | ABC | 1997–2003 | 6 | 1,633 | Soap opera |
| 98 | Judge Hatchett | Syndication | 2000–2008 | 10 | 1,630 | Court show |
| 99 | The Tonight Show Starring Jimmy Fallon | NBC | 2014 | 8 | 1,598 | Late-night talk show |
| 100 | Caso Cerrado | Telemundo | 2001 | — | 1,578 | Reality |