| 1 | Guiding Light | CBS | 1937–2009 | 72 | 15,762 | Soap opera |
| 2 | CBS Weekend News | CBS | 1966 | 72 | — | News |
| 3 | PGA Tour on CBS | CBS | 1956 | 71 | — | — |
| 4 | Meet the PressNews program | NBC | 1947 | 70 | 1,414 | Public affairs |
| 5 | TodayNews program | NBC | 1952 | 68 | 5,081 | Talk show |
| 6 | Backyard Farmer | PBS | 1953 | 64 | 1,280 | Documentary |
| 7 | Face the Nation with Margaret BrennanNews program | CBS | 1954 | 64 | — | News |
| 8 | General Hospital | ABC | 1963 | 64 | 16,230 | LGBTQ |
| 9 | Hallmark Hall of Fame | NBC | 1951 | 63 | 255 | Drama |
| 10 | Tennis on NBC | NBC | 1955 | 60 | — | — |
| 11 | 60 MinutesNews program | CBS | 1968 | 57 | 2,325 | Documentary |
| 12 | Sesame Street | HBO | 1969 | 56 | 4,744 | Educational |
| 13 | As the World Turns | CBS | 1956–2010 | 54 | 13,858 | Soap opera |
| 14 | CBS Sports Spectacular | CBS | 1960 | 54 | — | Anthology |
| 15 | Monday Night Football | ABC, ESPN+ | 1970 | 54 | 718 | Sports |
| 16 | Disney anthology television series | ABC | 1954–2008 | 53 | 1,224 | Anthology |
| 17 | Sábado Gigante | Univision, Canal 13 | 1962–2015 | 53 | 2,778 | — |
| 18 | The Young and the Restless | CBS | 1973 | 53 | 12,775 | Soap opera |
| 19 | Great Performances | PBS | 1972 | 52 | — | Drama |
| 20 | Saturday Night Live | NBC | 1975 | 52 | 1,010 | Stand-up comedy |
| 21 | Washington Week with The Atlantic | PBS | 1967 | 50 | 2,000 | Public affairs |
| 22 | The Price Is RightGame show | CBS, Syndication | 1972 | 50 | 9,000 | Game show |
| 23 | Nova | PBS | 1974 | 50 | 959 | Documentary |
| 24 | Survivor | CBS | 2000 | 50 | 722 | Reality |
| 25 | The NFL Today | CBS | 1961 | 48 | — | Pre-game show |
| 26 | Tennis on CBS | CBS | 1968–2014 | 46 | — | — |
| 27 | One Life to Live | ABC | 1968–2013 | 45 | 11,136 | Soap opera |
| 28 | Good Morning AmericaNews program | ABC | 1975 | 45 | 8,779 | News |
| 29 | Name That TuneGame show | NBC, Fox | 1952–1985 | 43 | 195 | Music |
| 30 | All My Children | ABC, The Online Network | 1970–2013 | 43 | 10,755 | LGBTQ |
| 31 | Live from Lincoln Center | PBS | 1976 | 43 | 251 | — |
| 32 | This Old House | PBS | 1979–2021 | 42 | 1,212 | — |
| 33 | College Basketball on CBS Sports | CBS, CBS Sports Network | 1981 | 42 | — | — |
| 34 | FrontlineWeb series | PBS | 1983 | 42 | 775 | Documentary |
| 35 | Nightly Business Report | PBS, WPBT | 1979–2019 | 40 | 12,000 | News magazine |
| 36 | The Bold and the Beautiful | CBS | 1987 | 40 | 9,898 | Soap opera |
| 37 | Ridiculousness | MTV | 2011 | 40 | 1,412 | Comedy |
| 38 | Family Classics | WGN-TV | 1962–2000 | 39 | 971 | — |
| 39 | Captain Kangaroo | CBS | 1955–1984 | 38 | 6,090 | Children's |
| 40 | This Week with Sam Donaldson and Cokie RobertsNews program | ABC | 1960–2002 | 38 | — | Talk show |
| 41 | 20/20News program | ABC | 1978 | 38 | 500 | News |
| 42 | America Held HostageNews program | ABC, ABC News | 1979 | 38 | — | News broadcasting |
| 43 | CBS News Sunday MorningNews program | CBS | 1979 | 38 | — | News magazine |
| 44 | ESPN SportsCenter | ESPN, ESPN2 | 1979 | 38 | — | — |
| 45 | The Woodwright's Shop | PBS, PBS North Carolina | 1979–2017 | 38 | 481 | — |
| 46 | The SimpsonsAnimated series | Fox | 1989 | 38 | 813 | Satire |
| 47 | American Bandstand | ABC, Syndication | 1952–1989 | 37 | 3,000 | Music |
| 48 | Wide World of Sports | ABC | 1961–1997 | 37 | 383 | Anthology |
| 49 | MotorWeek | Maryland Public Television | 1981 | 37 | — | — |
| 50 | Divorce Court | Syndication | 1957 | 36 | 5,767 | — |
| 51 | The Victory Garden | PBS | 1975–2015 | 36 | — | — |
| 52 | Entertainment Tonight | Syndication | 1981 | 36 | 10,415 | Entertainment journalism |
| 53 | Nature | PBS | 1982 | 36 | 521 | Documentary |
| 54 | The Challenge | MTV | 1998 | 36 | 374 | Reality |
| 55 | Chopped | Food Network | 2009 | 36 | 698 | Cooking show |
| 56 | Search for Tomorrow | NBC, CBS | 1951–1986 | 35 | 9,130 | Soap opera |
| 57 | Another World | NBC | 1964–1999 | 35 | 8,891 | Soap opera |
| 58 | American Masters | PBS | 1986 | 35 | — | Biography |
| 59 | Firing Line With Margaret Hoover | PBS | 1966 | 34 | 1,504 | Talk show |
| 60 | Point of View | PBS | 1988 | 34 | 224 | Documentary |
| 61 | Inside Edition WeekendNews program | Syndication | 1989 | 34 | 11,257 | News magazine |
| 62 | Good Morning America First LookNews program | ABC | 1982 | 33 | — | News broadcasting |
| 63 | Cops | Fox, Fox Nation | 1989 | 33 | 1,103 | Documentary |
| 64 | The Real World | MTV | 1992–2019 | 33 | 614 | Docu-soap |
| 65 | How It's Made | Science Channel, USA Network (Canada) | 2001–2019 | 32 | 416 | Documentary |
| 66 | The Amazing Race | CBS | 2001 | 32 | 373 | Game show |
| 67 | Mister Rogers' Neighborhood | National Educational Television, PBS | 1968–2001 | 31 | 905 | — |
| 68 | The Joy of Painting | PBS | 1983–1994 | 31 | 403 | — |
| 69 | America's Funniest Home Videos | ABC | 1989 | 31 | 703 | Comedy |
| 70 | Maury | | 1991–2022 | 31 | 2,640 | Tabloid talk show |
| 71 | WWE Raw | The National Network, WWE Network | 1993 | 31 | 1,723 | Professional wrestling |
| 72 | The Daily Show | Comedy Central | 1996 | 31 | 4,214 | Political satire |
| 73 | The Tonight Show Starring Johnny Carson | NBC | 1962–1992 | 30 | 4,531 | Late-night talk show |
| 74 | American Experience | PBS | 1988 | 30 | 313 | Documentary |
| 75 | Inside EditionNews program | Syndication, KBS Prime | 1989 | 30 | 11,257 | Entertainment journalism |
| 76 | The Ultimate Fighter | Spike TV | 2005–2018 | 30 | 150 | Sports |
| 77 | Love of Life | CBS | 1951–1980 | 29 | 7,316 | Soap opera |
| 78 | America's Black ForumNews program | Syndication | 1970 | 29 | — | News magazine |
| 79 | Whiz Quiz | WPBS-TV | 1980 | 29 | — | Game show |
| 80 | Hometime | PBS | 1986–2016 | 29 | — | — |
| 81 | 48 HoursNews program | CBS, Investigation Discovery | 1988–2004 | 29 | 991 | Documentary |
| 82 | South ParkAnimated series | Comedy Central, Canal+ Polska | 1997 | 29 | 344 | Surreal humour |
| 83 | Dancing with the Stars | ABC, Disney+ | 2005 | 29 | 459 | Talent show |
| 84 | The Edge of Night | CBS | 1956–1984 | 28 | 7,420 | Soap opera |
| 85 | Pyramid | CBS, ABC | 1973 | 28 | 1,211 | Quiz show |
| 86 | Fox News Sunday with Shannon Bream | Fox, Fox News | 1996 | 28 | 1,476 | News |
| 87 | The View | ABC | 1997 | 28 | 6,000 | Talk show |
| 88 | WWE SmackDown | MyNetworkTV, Fox | 1999 | 28 | 1,397 | Sports entertainment |
| 89 | Law & Order: Special Victims Unit | NBC | 1999 | 28 | 594 | Mystery |
| 90 | Big Brother | CBS | 2000 | 28 | 1,016 | Game show |
| 91 | Mystery! | PBS | 1980–2006 | 27 | 648 | Anthology |
| 92 | Sunday Night Baseball | ESPN | 1990 | 27 | — | — |
| 93 | Notre Dame Football on NBC | NBC | 1991 | 27 | 175 | — |
| 94 | The Voice | NBC | 2011 | 27 | 648 | Singing talent show |
| 95 | Hee Haw | CBS | 1969–1992 | 26 | 655 | Comedy |
| 96 | Hollywood Squares | NBC, CBS | 1983 | 26 | 3,536 | Quiz show |
| 97 | Law & Order | NBC | 1990 | 26 | 523 | Police procedural |
| 98 | The Jerry Springer Show | Syndication | 1991–2018 | 26 | 3,891 | Tabloid talk show |
| 99 | Real Sports with Bryant GumbelNews program | HBO | 1995 | 26 | 284 | — |
| 100 | What's My Line? | CBS | 1950–1975 | 25 | 2,196 | Panel game |