| 1 | Guiding Light | CBS | 1937–2009 | 72 | 15,762 | 73 |
| 2 | Beat the Clock | CBS, Ion Television | 1950–2019 | 18 | 100 | 70 |
| 3 | College Bowl | CBS, NBC | 1953–2022 | 12 | 56 | 70 |
| 4 | To Tell the Truth | CBS, Canale 5 | 1956–2022 | — | — | 67 |
| 5 | Queen for a Day | Mutual Broadcasting System | 1945–2004 | — | — | 60 |
| 6 | It Is Written | Trinity Broadcasting Network, Three Angels Broadcasting Network | 1956–2015 | — | 50 | 60 |
| 7 | Match Game | CBS, ABC | 1962–2021 | — | 1,760 | 60 |
| 8 | The Early ShowNews program | CBS | 1954–2012 | 13 | 3,578 | 59 |
| 9 | Supermarket Sweep | Ion Television, ABC | 1965–2022 | 10 | 1,111 | 58 |
| 10 | Disney anthology television series | ABC | 1954–2008 | 53 | 1,224 | 55 |
| 11 | As the World Turns | CBS | 1956–2010 | 54 | 13,858 | 55 |
| 12 | Sábado Gigante | Univision, Canal 13 | 1962–2015 | 53 | 2,778 | 54 |
| 13 | Finland Calling | WLUC-TV | 1962–2015 | — | — | 54 |
| 14 | Tennessee Tuxedo and His TalesAnimated series | CBS | 1963–2014 | — | 75 | 52 |
| 15 | On the MoneyNews program | Syndication | 1970–2019 | — | — | 50 |
| 16 | Wild Kingdom | NBC, Animal Planet | 1963–2011 | — | 140 | 49 |
| 17 | The Jerry Lewis MDA Labor Day Telethon | ABC, Syndication | 1966–2014 | — | 46 | 49 |
| 18 | Tennis on CBS | CBS | 1968–2014 | 46 | — | 47 |
| 19 | Inside the NFL | HBO | 1977–2023 | — | — | 47 |
| 20 | One Life to Live | ABC | 1968–2013 | 45 | 11,136 | 46 |
| 21 | Wall $treet Week | PBS | 1970–2015 | — | — | 46 |
| 22 | Davey and GoliathAnimated series | Syndication | 1961–2004 | 5 | 72 | 44 |
| 23 | All My Children | ABC, The Online Network | 1970–2013 | 43 | 10,755 | 44 |
| 24 | Card Sharks | NBC, ABC | 1978–2021 | — | 842 | 44 |
| 25 | This Week with Sam Donaldson and Cokie RobertsNews program | ABC | 1960–2002 | 38 | — | 43 |
| 26 | This Old House | PBS | 1979–2021 | 42 | 1,212 | 43 |
| 27 | Make Me Laugh | ABC | 1958–1998 | — | — | 41 |
| 28 | The Bugs Bunny ShowAnimated series | ABC | 1960–2000 | — | — | 41 |
| 29 | The NBC Monday Movie | NBC | 1963–2003 | — | — | 41 |
| 30 | The Victory Garden | PBS | 1975–2015 | 36 | — | 41 |
| 31 | Nightly Business Report | PBS, WPBT | 1979–2019 | 40 | 12,000 | 41 |
| 32 | Superstars | TV3 Sverige | 1973–2012 | 17 | — | 40 |
| 33 | Family Classics | WGN-TV | 1962–2000 | 39 | 971 | 39 |
| 34 | The Woodwright's Shop | PBS, PBS North Carolina | 1979–2017 | 38 | 481 | 39 |
| 35 | The McLaughlin GroupNews program | Syndication | 1982–2020 | — | — | 39 |
| 36 | American Bandstand | ABC, Syndication | 1952–1989 | 37 | 3,000 | 38 |
| 37 | Lingo | CBS, Game Show Network | 1987–2024 | — | — | 38 |
| 38 | Wide World of Sports | ABC | 1961–1997 | 37 | 383 | 37 |
| 39 | Schoolhouse Rock!Animated series | ABC | 1973–2009 | 7 | 64 | 37 |
| 40 | Search for Tomorrow | NBC, CBS | 1951–1986 | 35 | 9,130 | 36 |
| 41 | The Wallace and Ladmo Show | KPHO-TV | 1954–1989 | — | — | 36 |
| 42 | Another World | NBC | 1964–1999 | 35 | 8,891 | 36 |
| 43 | Columbo | NBC, ABC | 1968–2003 | 10 | 69 | 36 |
| 44 | Soul Train | Syndication, WCIU-TV | 1971–2006 | — | 1,117 | 36 |
| 45 | The Dating Game | ABC | 1965–1999 | — | — | 35 |
| 46 | Name That TuneGame show | NBC, Fox | 1952–1985 | 43 | 195 | 34 |
| 47 | Mister Rogers' Neighborhood | National Educational Television, PBS | 1968–2001 | 31 | 905 | 34 |
| 48 | Double Dare | Fox, Nickelodeon | 1986–2019 | 1 | 482 | 34 |
| 49 | Late Show | CBS | 1993–2026 | — | — | 34 |
| 50 | Crossfire | CNN | 1982–2014 | — | — | 33 |
| 51 | Maury | | 1991–2022 | 31 | 2,640 | 32 |
| 52 | The Tonight Show Starring Johnny Carson | NBC | 1962–1992 | 30 | 4,531 | 31 |
| 53 | Hometime | PBS | 1986–2016 | 29 | — | 31 |
| 54 | Love of Life | CBS | 1951–1980 | 29 | 7,316 | 30 |
| 55 | Captain Kangaroo | CBS | 1955–1984 | 38 | 6,090 | 30 |
| 56 | The Phil Donahue Show | WDTN | 1967–1996 | — | 5,515 | 30 |
| 57 | College Basketball on NBC | NBC | 1969–1998 | — | — | 30 |
| 58 | Lilias, Yoga and You | PBS | 1970–1999 | — | 500 | 30 |
| 59 | Midnight Blue | Channel J | 1974–2003 | — | — | 30 |
| 60 | TV's Bloopers & Practical Jokes | ABC, NBC | 1984–2013 | — | — | 30 |
| 61 | The Sports Reporters | Compass Media Networks, ESPN | 1988–2017 | — | — | 30 |
| 62 | Legends of the Hidden Temple | Nickelodeon, The CW | 1993–2022 | 4 | 133 | 30 |
| 63 | The Edge of Night | CBS | 1956–1984 | 28 | 7,420 | 29 |
| 64 | It Takes Two | NBC, Freeform | 1969–1997 | — | — | 29 |
| 65 | Live at Five | WNBC | 1979–2007 | — | — | 29 |
| 66 | The Late Late Show | CBS | 1995–2023 | — | 5,346 | 29 |
| 67 | The Lawrence Welk Show | KTLA | 1955–1982 | — | 1,065 | 28 |
| 68 | Win, Lose or Draw | NBC, Disney Channel | 1987–2014 | 7 | 598 | 28 |
| 69 | The Jerry Springer Show | Syndication | 1991–2018 | 26 | 3,891 | 28 |
| 70 | The Real World | MTV | 1992–2019 | 33 | 614 | 28 |
| 71 | Happy Tree FriendsAnimated series | G4 | 1999–2026 | 5 | 93 | 28 |
| 72 | Mystery! | PBS | 1980–2006 | 27 | 648 | 27 |
| 73 | Charlie Rose | PBS, Bloomberg Television | 1991–2017 | — | — | 27 |
| 74 | Entertainment News TelevisionNews program | Syndication | 1994–2020 | 23 | 6,329 | 27 |
| 75 | ArthurAnimated series | PBS | 1996–2022 | 25 | 253 | 27 |
| 76 | FuturamaAnimated series | Comedy Central, Hulu | 1999–2025 | 11 | 151 | 27 |
| 77 | It Pays to Be Ignorant | CBS, NBC | 1949–1974 | 3 | — | 26 |
| 78 | What's My Line? | CBS | 1950–1975 | 25 | 2,196 | 26 |
| 79 | Sunrise Semester | CBS | 1957–1982 | 25 | 800 | 26 |
| 80 | The JetsonsAnimated series | ABC, Syndication | 1962–1987 | 3 | 75 | 26 |
| 81 | ABC Afterschool Special | ABC | 1972–1997 | 25 | 139 | 26 |
| 82 | CNN DaybreakNews program | CNN | 1980–2005 | — | — | 26 |
| 83 | Larry King Live | CNN | 1985–2010 | — | 6,120 | 26 |
| 84 | The Oprah Winfrey Show | CBS | 1986–2011 | 25 | 4,561 | 26 |
| 85 | Headbangers Ball | MTV, MTV2 | 1987–2012 | — | 410 | 26 |
| 86 | Biography | CBS | 1987–2012 | — | — | 26 |
| 87 | The X-Files | Fox | 1993–2018 | 11 | 218 | 26 |
| 88 | Judge Judy | Syndication | 1996–2021 | 25 | 6,260 | 26 |
| 89 | Home & Family | Hallmark Channel | 1996–2021 | 4 | — | 26 |
| 90 | MSNBC ReportsNews program | MS NOW | 1996–2021 | — | 719 | 26 |
| 91 | House Party | CBS, CBS News Radio | 1945–1969 | — | — | 25 |
| 92 | Garfield Goose and Friends | WBBM-TV | 1952–1976 | 24 | — | 25 |
| 93 | The Bear Bryant Show | WVTM-TV | 1958–1982 | 25 | — | 25 |
| 94 | The Merv Griffin Show | NBC | 1962–1986 | — | 4,855 | 25 |
| 95 | Olympics on ABC | ESPN on ABC | 1964–1988 | 10 | — | 25 |
| 96 | Northwest Afternoon | KOMO-TV | 1984–2008 | 24 | — | 25 |
| 97 | The Big Spin | Syndication | 1985–2009 | 24 | 1,213 | 25 |
| 98 | Curb Your Enthusiasm | HBO | 2000–2024 | 12 | 120 | 25 |
| 99 | The Ed Sullivan Show | CBS | 1948–1971 | 24 | 1,068 | 24 |
| 100 | J. P. Patches | KIRO-TV | 1958–1981 | 24 | 10,000 | 24 |