| Jul 4 | SK8-TV | 1990 | — | 13 | — | |
| Feb 3 | Hillside | 1991–1993 | 4 | 65 | Soap opera | |
| Feb 16 | Welcome Freshmen | 1991–1994 | 3 | 52 | Comedy | Bob Mittenthal |
| Mar 18 | Get the Picture | 1991 | 2 | 115 | — | Marjorie Cohn |
| Mar 23 | Clarissa Explains It All | 1991–1994 | 5 | 65 | Children's | Mitchell Kriegman |
| May 9 | Nickelodeon Launch Box | 1991–1994 | 1 | 9 | — | |
| Jul 4 | Salute Your Shorts | 1991–1992 | 2 | 26 | Teen sitcom | |
| Aug 11 | Brand Spanking New! DougAnimated series | 1991–1999 | 7 | 117 | Children's | Jim Jinkins |
| Aug 11 | RugratsAnimated series | 1991–2004 | 9 | 172 | Children's | Arlene Klasky |
| Aug 11 | The Ren & Stimpy ShowAnimated series | 1991–1995 | 5 | 52 | Comedy | Bob Camp, Jim Smith |
| Aug 31 | What Would You Do? | 1991–1993 | 2 | 90 | — | |
| Jan 4 | Nick Arcade | 1992 | 2 | 84 | — | |
| Apr 18 | Nick NewsNews program | 1992–2015 | 24 | 178 | Educational | Linda Ellerbee |
| Aug 15 | Roundhouse | 1992–1996 | 4 | 52 | — | Buddy Sheffield |
| Sep 19 | Nickelodeon Guts | 1992–1995 | 4 | 160 | Game show | |
| Jul 11 | Weinerville | 1993–1997 | 2 | 62 | — | Marc Weiner |
| Sep 11 | Legends of the Hidden Temple | 1993–2022 | 4 | 133 | Game show | Stephen Brown |
| Sep 18 | Rocko's Modern LifeAnimated series | 1993–1996 | 4 | 52 | Children's | Joe Murray |
| Nov 28 | The Adventures of Pete & Pete | 1993–1996 | 3 | 34 | Comedy | Chris Viscardi, Will McRobb |
| — | The Big Help | 1994 | 8 | 8 | Reality | |
| Apr 16 | All That | 1994–2005 | 11 | 210 | Sketch comedy | Brian Robbins |
| Oct 3 | U to U | 1994–1996 | — | 20 | — | |
| Oct 8 | The Secret World of Alex Mack | 1994–1998 | 4 | 78 | Science fiction | Thomas W. Lynch |
| Oct 15 | My Brother and Me | 1994–1995 | 1 | 13 | Sitcom | |
| Oct 24 | Gullah Gullah Island | 1994–2000 | 5 | 72 | — | |
| Oct 29 | Aaahh!!! Real MonstersAnimated series | 1994–1997 | 4 | 52 | Comedy | Gábor Csupó |
| Oct 14 | Action League Now!Animated series | 1995–2002 | 5 | 65 | Action | Bob Mittenthal |
| Nov 5 | Mina and the CountAnimated series | 1995–1999 | 1 | 6 | — | Rob Renzetti |
| Mar 2 | Space Cases | 1996–1997 | 2 | 27 | Science fiction | Peter David |
| Mar 16 | The Mystery Files of Shelby Woo | 1996–1998 | 4 | 41 | Detective | Alan Goodman |
| Jul 15 | Kenan & Kel | 1996–2001 | 4 | 65 | Sitcom | |
| Sep 8 | Blue's Clues | 1996–2006 | 6 | 142 | Educational | Traci Paige Johnson, Todd Kessler |
| Sep 9 | Hey Arnold!Animated series | 1996–2004 | 5 | 100 | Comedy-drama | Craig Bartlett |
| Oct 1 | KaBlam!Animated series | 1996–2000 | 4 | 47 | Comedy | Bob Mittenthal, Will McRobb |
| Oct 7 | Sniz & Fondue | 1996–1998 | — | 24 | — | |
| Oct 13 | The Wubbulous World of Dr. Seuss | 1996–1998 | 2 | 40 | — | Dr. Seuss |
| Nov 29 | The Off-BeatsAnimated series | 1996–1998 | 2 | 14 | Children's | Mo Willems |
| Apr 19 | The Angry BeaversAnimated series | 1997–2001 | 4 | 64 | Animated sitcom | Mitch Schauer |
| Jul 7 | Figure It Out | 1997–2013 | 5 | 196 | Panel game | Kevin Kay |
| Nov 8 | The Journey of Allen Strange | 1997–2000 | 3 | 57 | Science fiction | Thomas W. Lynch |
| Apr 4 | CatDogAnimated series | 1998–2005 | 4 | 66 | Children's | |
| Jul 18 | Oh Yeah! CartoonsAnimated series | 1998–2013 | 4 | 75 | Anthology | Fred Seibert |
| Aug 3 | You're On! | 1998–1999 | 1 | 26 | Game show | |
| Sep 1 | Cousin Skeeter | 1998–2002 | 3 | 52 | Teen sitcom | |
| Sep 1 | The Wild ThornberrysAnimated series | 1998–2004 | 5 | 91 | Adventure | Arlene Klasky |
| Sep 4 | Animorphs | 1998–1999 | 2 | 26 | Science fiction | Katherine Applegate |
| — | The Brothers FlubAnimated series | 1999–2000 | 1 | 26 | Comedy | |
| May 1 | SpongeBob SquarePantsAnimated series | 1999 | 16 | 330 | Fantasy | Stephen Hillenburg |
| Aug 16 | Rocket PowerAnimated series | 1999–2004 | 4 | 64 | Animation | Klasky Csupo |
| Oct 6 | The Amanda Show | 1999–2002 | 3 | 46 | Comedy | Dan Schneider |
| Oct 16 | 100 Deeds for Eddie McDowd | 1999–2002 | 3 | 40 | Teen sitcom | |
| Nov 28 | Little BillAnimated series | 1999–2003 | 5 | 127 | Educational | Bill Cosby |