| — | Jimmy Neutron: Boy Genius ShortsAnimated series | 2000 | 2 | 12 | Comedy | John A. Davis |
| — | Oobi | 2000–2005 | 3 | 52 | Puppetry | Josh Selig |
| Jan 24 | Slime Time Live | 2000–2004 | 8 | 13 | Game show | |
| Mar 11 | Caitlin's Way | 2000–2002 | 3 | 52 | Drama | |
| Jul 23 | The Brothers García | 2000–2004 | 4 | 50 | Sitcom | |
| Aug 14 | Dora the ExplorerAnimated series | 2000–2015 | 8 | 172 | Children's | |
| Oct 7 | Noah Knows Best | 2000–2001 | 1 | 13 | Teen sitcom | |
| Oct 25 | As Told by GingerAnimated series | 2000–2016 | 3 | 60 | Comedy-drama | Emily Kapnek |
| Jan 1 | Butt-Ugly MartiansAnimated series | 2001–2003 | 1 | 26 | Action | |
| Jan 14 | Taina | 2001–2002 | 2 | 26 | Teen sitcom | |
| Mar 30 | Invader ZimAnimated series | 2001–2006 | 2 | 27 | Comedy | Jhonen Vasquez |
| Mar 30 | The Fairly OddParentsAnimated series | 2001–2017 | 10 | 172 | Children's | Butch Hartman |
| Aug 20 | OswaldAnimated series | 2001–2003 | 1 | 26 | Children's | Dan Yaccarino |
| Jan 12 | The Nick Cannon Show | 2002–2003 | 2 | 27 | — | Nick Cannon |
| Mar 22 | ChalkZoneAnimated series | 2002–2008 | 4 | 40 | Comedy | Larry Huber, Bill Burnett |
| Jul 20 | The Adventures of Jimmy Neutron, Boy GeniusAnimated series | 2002–2006 | 3 | 64 | Science fiction | John A. Davis, Steve Oedekerk |
| Aug 25 | Nickelodeon Robot Wars | 2002 | — | 6 | — | |
| Sep 7 | Moville MysteriesAnimated series | 2002–2003 | 2 | 26 | Comedy | |
| Oct 14 | U-Pick Live | 2002–2005 | 5 | 401 | — | |
| Oct 27 | Scaredy Camp | 2002–2003 | 2 | 10 | Reality | |
| Apr 12 | All Grown Up!Animated series | 2003–2008 | 5 | 55 | Comedy | Arlene Klasky |
| Aug 1 | My Life as a Teenage RobotAnimated series | 2003–2007 | 3 | 40 | Science fiction | Rob Renzetti |
| Sep 13 | Romeo! | 2003–2006 | 4 | 53 | Teen sitcom | |
| Jan 11 | Drake & Josh | 2004–2007 | 4 | 57 | Teen sitcom | Dan Schneider |
| Jan 18 | Whoopi's Littleburg | 2004 | 1 | 3 | — | |
| Jan 28 | Winx ClubAnimated series | 2004–2019 | 8 | 208 | Fantasy | Iginio Straffi |
| Mar 7 | Nickelodeon Splat! | 2004 | 1 | — | Game show | |
| Apr 3 | Danny PhantomAnimated series | 2004–2007 | 3 | 53 | Children's | Butch Hartman |
| Jun 20 | FatherhoodAnimated series | 2004–2005 | 2 | 26 | Animated sitcom | Bill Cosby |
| Aug 2 | Blue's Room | 2004–2007 | 2 | 17 | Comedy | Traci Paige Johnson |
| Aug 31 | Curious Buddies | 2004–2005 | 1 | 7 | — | |
| Sep 12 | Ned's Declassified School Survival Guide | 2004–2007 | 3 | 55 | Slapstick | Scott Fellows |
| Sep 12 | Unfabulous | 2004–2007 | 3 | 42 | Sitcom | Sue Rose |
| Oct 11 | The BackyardigansAnimated series | 2004–2013 | 4 | 80 | Fantasy | Janice Burgess |
| — | The Search for the Funniest Mom in America | 2005–2007 | — | 18 | Comedy | Nick at Nite |
| Jan 9 | Zoey 101 | 2005–2008 | 4 | 65 | Teen sitcom | Dan Schneider |
| Feb 21 | Avatar: The Last AirbenderAnimated series | 2005–2008 | 3 | 61 | Fantasy | Michael Dante DiMartino, Bryan Konietzko |
| Jul 9 | CatscratchAnimated series | 2005–2007 | 1 | 20 | Children's | Doug TenNapel |
| Sep 6 | Go, Diego, Go!Animated series | 2005–2011 | 4 | 86 | Comedy | |
| Nov 25 | The X's | 2005–2006 | 1 | 21 | Animation | Carlos Ramos |
| Dec 30 | Mr. Meaty | 2005–2009 | 2 | 20 | Comedy | Jamie Shannon |
| — | Just for Kicks | 2006 | 1 | 13 | Comedy-drama | Whoopi Goldberg |
| Jan 1 | Rugrats Pre-School DazeAnimated series | 2006–2008 | 1 | 4 | — | Arlene Klasky |
| Mar 3 | Wonder Pets!Animated series | 2006–2016 | 3 | 62 | Comedy | Josh Selig |
| Aug 28 | Wow! Wow! Wubbzy!Animated series | 2006–2010 | 2 | 52 | Comedy | Bob Boyle |
| Jan 7 | Just Jordan | 2007–2008 | 2 | 29 | Comedy | |
| Feb 3 | The Naked Brothers Band | 2007–2009 | 3 | 40 | Teen sitcom | Polly Draper |
| Feb 27 | Are You Smarter than a 5th Grader? | 2007–2019 | 6 | 98 | Quiz show | Mark Burnett |
| Mar 3 | El Tigre: The Adventures of Manny RiveraAnimated series | 2007–2008 | 1 | 26 | Comedy | Jorge R. Gutiérrez |
| Aug 20 | Yo Gabba Gabba! | 2007–2015 | 4 | 66 | Children and youth | |
| Aug 31 | Tak and the Power of JujuAnimated series | 2007–2008 | 2 | 26 | Fantasy | |
| Sep 8 | iCarly | 2007–2012 | 7 | 97 | Teen sitcom | Dan Schneider |
| Sep 29 | Back at the BarnyardAnimated series | 2007–2011 | 2 | 52 | Comedy | Steve Oedekerk |
| Oct 7 | Edgar & EllenAnimated series | 2007–2008 | 2 | 24 | Comedy | Charles Ogden |
| — | Domo-kunAnimated series | 2008–2009 | 1 | 26 | Slice of life | |
| Feb 7 | Ni Hao, Kai-LanAnimated series | 2008–2011 | 3 | 42 | Family | Karen Chau |
| Mar 29 | Dance on Sunset | 2008 | 1 | 12 | Reality | |
| Apr 22 | The Big Green Help | 2008–2009 | — | — | Reality | |
| Apr 26 | The Mighty B!Animated series | 2008–2011 | 2 | 40 | Comedy | Amy Poehler |
| Jun 20 | Sa Re Ga Ma Pa Challenge USA 2008 | 2008 | — | 13 | — | |
| Sep 15 | My Family's Got Guts | 2008–2009 | 2 | 22 | — | |
| Nov 8 | True Jackson | 2008–2011 | 3 | 60 | Sitcom | Andy Gordon |
| Nov 29 | The Penguins of MadagascarAnimated series | 2008–2015 | 3 | 80 | Children's | Eric Darnell, Tom McGrath |
| Aug 17 | Glenn Martin, DDSAnimated series | 2009–2011 | 2 | 40 | Comedy | |
| Aug 24 | The Fresh Beat Band | 2009–2013 | 3 | 52 | Children's music | Scott Kraft |
| Sep 12 | The Troop | 2009–2013 | 2 | 40 | Science fiction | Andy Gordon |
| Sep 28 | BrainSurge | 2009–2014 | 3 | 120 | Game show | |
| Nov 6 | Fanboy & Chum ChumAnimated series | 2009–2014 | 2 | 52 | Comedy | |
| Nov 28 | Big Time Rush | 2009–2013 | 4 | 74 | Comedy | Scott Fellows |