| Jan 15 | Human Target | 2010–2011 | 2 | 25 | Crime | |
| Feb 9 | Past Life | 2010 | 1 | 7 | Detective | |
| Mar 11 | Sons of Tucson | 2010 | 1 | 13 | Sitcom | |
| May 19 | The Good Guys | 2010 | 1 | 20 | Comedy-drama | Matt Nix |
| Jun 14 | PokerStars Big Game | 2010–2011 | 2 | 115 | — | |
| Jul 27 | MasterChef | 2010 | 12 | 205 | Reality | Endemol Shine North America, Franc Roddam |
| Sep 20 | Lone Star | 2010 | 1 | 2 | Drama | Kyle Killen |
| Sep 21 | Raising Hope | 2010–2014 | 4 | 88 | Sitcom | Greg Garcia |
| Sep 21 | Running Wilde | 2010–2011 | 1 | 13 | Sitcom | Mitchell Hurwitz |
| Dec 20 | Million Dollar Money Drop | 2010–2011 | 1 | 12 | Game show | |
| Jan 9 | Bob's BurgersAnimated series | 2011 | 16 | 313 | Musical | |
| Feb 7 | The Chicago Code | 2011 | 1 | 13 | Crime | Shawn Ryan |
| Feb 8 | Traffic Light | 2011 | 1 | 13 | Sitcom | |
| Mar 31 | Mobbed | 2011–2013 | 1 | 11 | Reality | Howie Mandel |
| Apr 6 | Breaking In | 2011–2012 | 2 | 20 | Sitcom | Adam Frederick Goldberg, Seth Gordon |
| Aug 14 | In the Flow with Affion Crockett | 2011 | 1 | 6 | — | |
| Aug 24 | Buried Treasure | 2011 | 1 | 4 | Reality | |
| Sep 20 | New Girl | 2011–2018 | 7 | 146 | Sitcom | Elizabeth Meriwether |
| Sep 21 | The X Factor | 2011–2013 | 3 | 80 | Talent show | Simon Cowell |
| Sep 26 | Terra Nova | 2011 | 1 | 13 | Science fiction | Brannon Braga, Kelly Marcel |
| Oct 11 | Last Man Standing | 2011–2021 | 9 | 194 | Sitcom | Jack Burditt |
| Oct 25 | The X Factor Digital Experience | 2011 | 1 | 15 | — | |
| Oct 30 | Allen GregoryAnimated series | 2011 | 1 | 7 | Adult animation | Jonah Hill |
| Nov 12 | Fox UFC | 2011–2018 | 4 | — | — | |
| Nov 30 | I Hate My Teenage Daughter | 2011–2012 | 1 | 13 | Sitcom | |
| Jan 12 | The Finder | 2012 | 1 | 13 | Procedural drama | Hart Hanson |
| Jan 15 | Napoleon DynamiteAnimated series | 2012 | 1 | 6 | Comedy | Jared Hess |
| Jan 16 | Alcatraz | 2012 | 1 | 13 | Crime | Elizabeth Sarnoff, J. J. Abrams |
| Jan 25 | Touch | 2012–2013 | 2 | 26 | Drama | Tim Kring |
| Jun 7 | The Choice | 2012 | 1 | 6 | Dating game show | |
| Aug 13 | Hotel Hell | 2012–2016 | 3 | 18 | Reality | |
| Sep 17 | The Mob Doctor | 2012–2013 | 1 | 13 | Drama | |
| Sep 25 | Ben and Kate | 2012–2013 | 1 | 16 | Sitcom | |
| Sep 25 | The Mindy Project | 2012–2017 | 6 | 117 | Sitcom | Mindy Kaling |
| Jan 21 | The Following | 2013–2015 | 3 | 45 | Drama | Kevin Williamson |
| May 20 | The Goodwin Games | 2013 | 1 | 7 | Comedy | Carter Bays |
| May 23 | Does Someone Have to Go? | 2013 | 1 | 6 | Reality | |
| Jul 21 | Axe CopAnimated series | 2013–2015 | 2 | 22 | Adult animation | |
| Jul 21 | High School USA!Animated series | 2013–2015 | 1 | 12 | Adult animation | |
| Sep 8 | Fox NFL Kickoff | 2013 | 3 | — | Pre-game show | |
| Sep 16 | Sleepy Hollow | 2013–2017 | 4 | 62 | Drama | Alex Kurtzman |
| Sep 17 | Dads | 2013–2014 | 1 | 19 | Sitcom | |
| Sep 27 | MasterChef Junior | 2013 | 3 | 22 | Reality | |
| Nov 17 | Almost Human | 2013–2014 | 1 | 13 | Science fiction | J. H. Wyman |
| Nov 23 | Golan the InsatiableAnimated series | 2013–2015 | 2 | 12 | Comedy | |
| Nov 23 | Lucas Bros. Moving Co.Animated series | 2013–2015 | 2 | 17 | Adult animation | |
| Jan 10 | Enlisted | 2014 | 1 | 13 | Comedy | Kevin Biegel |
| Jan 23 | Rake | 2014 | 1 | 13 | Comedy-drama | |
| Mar 9 | Cosmos | 2014 | 1 | 13 | Documentary | Ann Druyan |
| Mar 27 | Surviving Jack | 2014 | 1 | 13 | Sitcom | Justin Halpern |
| May 5 | 24: Live Another Day | 2014 | 1 | 12 | Crime | Joel Surnow |
| May 13 | Riot | 2014 | 1 | 4 | — | |
| May 22 | Gang Related | 2014 | 1 | 13 | Drama | Chris Morgan |
| May 27 | I Wanna Marry "Harry" | 2014 | 1 | 8 | — | |
| Jul 28 | Bear Grylls Is Running Wild | 2014 | 2 | 14 | Docu-soap | |
| Sep 7 | Utopia | 2014 | 1 | 12 | Reality | |
| Sep 17 | Red Band Society | 2014–2015 | 1 | 13 | Comedy-drama | |
| Sep 22 | Gotham | 2014–2019 | 5 | 100 | Drama | Bruno Heller |
| Oct 2 | Gracepoint | 2014 | 1 | 10 | Drama | Chris Chibnall |
| Oct 5 | Mulaney | 2014–2015 | 1 | 13 | LGBTQ | |
| Jan 7 | Empire | 2015–2020 | 6 | 102 | Drama | Lee Daniels, Danny Strong |
| Jan 16 | World's Funniest Fails | 2015 | 2 | 18 | — | |
| Jan 22 | Backstrom | 2015 | 1 | 13 | Drama | Hart Hanson |
| Mar 1 | The Last Man on Earth | 2015–2018 | 4 | 56 | Post-apocalyptic | Will Forte |
| Mar 31 | Weird Loners | 2015 | 1 | 6 | Comedy | |
| May 14 | Wayward Pines | 2015–2016 | 2 | 20 | Mystery | Chad Hodge |
| May 27 | Bullseye | 2015 | 1 | 8 | — | |
| Jun 25 | Boom!Game show | 2015 | 1 | 10 | — | |
| Jul 21 | Knock Knock Live | 2015 | 1 | 2 | Reality | |
| Jul 22 | Home Free | 2015–2016 | 1 | 8 | Reality | |
| Sep 21 | Minority Report | 2015 | 1 | 10 | Science fiction | Max Borenstein |
| Sep 22 | Scream Queens | 2015–2016 | 2 | 23 | Comedy | Ryan Murphy |
| Sep 23 | Rosewood | 2015–2017 | 2 | 44 | LGBTQ | |
| Sep 29 | Grandfathered | 2015–2016 | 1 | 22 | Sitcom | Daniel Chun |
| Sep 29 | The Grinder | 2015–2016 | 1 | 22 | Sitcom | Jarrad Paul |
| Jan 3 | BordertownAnimated series | 2016 | 1 | 13 | Animated sitcom | |
| Jan 3 | Cooper Barrett's Guide to Surviving Life | 2016 | 1 | 13 | Sitcom | |
| Jan 13 | Second Chance | 2016 | 1 | 11 | Science fiction | Rand Ravich |
| Jan 24 | The X-Files, season 10Miniseries | 2016 | — | 6 | Science fiction | Chris Carter |
| Mar 12 | Party Over Here | 2016 | 1 | 6 | — | |
| Apr 14 | American Grit | 2016–2017 | 2 | 20 | Reality | |
| Sep 11 | Son of Zorn | 2016–2017 | 1 | 13 | Sitcom | |
| Sep 21 | Lethal Weapon | 2016–2019 | 3 | 40 | Comedy-drama | |
| Sep 22 | Pitch | 2016 | 1 | 10 | Drama | |
| Sep 23 | The Exorcist | 2016–2017 | 2 | 20 | Drama | Jeremy Slater |
| Dec 14 | Star | 2016–2019 | 3 | 48 | Drama | |
| Jan 1 | The Mick | 2017–2018 | 2 | 37 | Sitcom | |
| Jan 12 | My Kitchen Rules | 2017 | 1 | 8 | — | |
| Feb 5 | 24: Legacy | 2017 | 1 | 12 | Espionage | Joel Surnow, Evan Katz |
| Feb 6 | APB | 2017 | 1 | 12 | LGBTQ | |
| Mar 5 | Making History | 2017 | 1 | 9 | Comedy | |
| Mar 9 | Kicking & Screaming | 2017 | 1 | 8 | Reality | |
| Mar 22 | Shots Fired | 2017 | 1 | 10 | Drama | |
| Apr 7 | You the Jury | 2017 | 1 | 2 | Court show | |
| May 25 | Beat Shazam | 2017 | 3 | 42 | Game show | |
| May 31 | The F Word | 2017 | 1 | 3 | Cooking show | |
| Sep 10 | The Orville | 2017 | 3 | 36 | Science fiction | Seth MacFarlane |
| Oct 1 | Ghosted | 2017–2018 | 1 | 16 | Science fiction | |
| Oct 2 | The Gifted | 2017–2019 | 2 | 29 | Fantasy | Matt Nix |
| Jan 2 | LA to Vegas | 2018 | 1 | 15 | Comedy | |
| Jan 3 | 9-1-1 | 2018–on air | 9 | 142 | Drama | Brad Falchuk, Ryan Murphy |
| Jan 4 | The Four | 2018 | 2 | 14 | Singing talent show | |
| Jan 21 | The Resident | 2018–2023 | 6 | 107 | Medical drama | Amy Holden Jones |
| Jun 13 | Gordon Ramsay's 24 Hours to Hell and Back | 2018–2020 | 3 | 19 | Reality | |
| Sep 9 | Rel | 2018–2019 | — | 12 | Comedy | |
| Sep 28 | The Cool Kids | 2018–2019 | 1 | 22 | Sitcom | |
| Jan 2 | The Masked Singer | 2019–on air | 9 | 96 | Game show | |
| Jan 14 | The Passage | 2019 | 1 | 10 | Drama | |
| Feb 15 | Proven Innocent | 2019 | — | 13 | Legal drama | |
| Mar 19 | Mental Samurai | 2019–2021 | — | — | Game show | Mike Darnell, Arthur Smith |
| Jun 20 | Spin the Wheel | 2019 | — | — | Game show | |
| Jun 30 | What Just Happened??! with Fred Savage | 2019 | — | — | — | |
| Aug 7 | BH90210 | 2019 | 1 | 6 | Comedy-drama | |
| Sep 23 | Prodigal Son | 2019–2021 | 2 | 33 | Drama | Sam Sklaver, Chris Fedak |
| Sep 29 | Bless the HartsAnimated series | 2019–2021 | 2 | 34 | Adult animation | Emily Spivey |
| Oct 2 | Almost Family | 2019–2020 | 1 | 13 | Drama | |
| Dec 4 | The MoodysMiniseries | 2019–2021 | — | 6 | Comedy | |