| Jan 9 | Malcolm in the Middle | 2000–2006 | 7 | 151 | Coming-of-age | Linwood Boomer |
| Mar 20 | Titus | 2000–2002 | 3 | 54 | Sitcom | |
| Jun 5 | It's Your Chance of a Lifetime | 2000 | 1 | 5 | Game show | |
| Jul 17 | Opposite Sex | 2000 | 1 | 8 | Comedy-drama | Marc Silverstein |
| Aug 2 | American High | 2000–2001 | 1 | 13 | Reality | R. J. Cutler |
| Oct 3 | Dark Angel | 2000–2002 | 2 | 43 | Post-apocalyptic | James Cameron |
| Oct 6 | FreakyLinks | 2000–2001 | 1 | 13 | Science fiction | |
| Oct 23 | Boston Public | 2000–2004 | 4 | 81 | Drama | David E. Kelley |
| Nov 1 | Normal, Ohio | 2000 | 1 | 12 | Sitcom | Bonnie and Terry Turner |
| Nov 1 | The $treet | 2000 | 1 | 12 | Drama | |
| Jan 10 | Grounded for Life | 2001–2005 | 5 | 91 | Sitcom | William E. Martin |
| Jan 10 | Temptation Island | 2001 | 12 | 26 | Reality | |
| Feb 11 | NASCAR on Fox | 2001 | 15 | — | — | |
| Mar 4 | The Lone Gunmen | 2001 | 1 | 13 | Comedy | Vince Gilligan, Chris Carter |
| Mar 28 | Boot Camp | 2001 | 1 | 9 | Reality | |
| Jul 12 | Night Visions | 2001–2002 | 1 | 26 | Anthology | Dan Angel |
| Jul 24 | Murder in Small Town X | 2001 | 1 | 8 | Reality | |
| Sep 25 | Love Cruise | 2001 | 1 | 7 | Reality | Mary-Ellis Bunim |
| Sep 25 | Undeclared | 2001–2002 | 1 | 17 | College life | Judd Apatow |
| Sep 28 | Pasadena | 2001 | 1 | 13 | Soap opera | Mike White |
| Nov 6 | 24 | 2001–2010 | 8 | 192 | Crime | Robert Cochran, Joel Surnow |
| Nov 8 | The Tick | 2001–2002 | 1 | 9 | Comedy | Ben Edlund |
| Nov 14 | The Bernie Mac Show | 2001–2006 | 5 | 104 | Sitcom | Larry Wilmore |
| Jan 13 | The Chamber | 2002 | — | 6 | — | Mike Darnell |
| Jan 23 | That '80s Show | 2002 | 1 | 13 | Teen sitcom | Mark Brazill |
| Feb 9 | Power Rangers Wild Force | 2002 | 1 | 40 | Tokusatsu | Haim Saban |
| Mar 11 | The American Embassy | 2002 | 1 | 6 | Drama | James D. Parriott |
| Mar 19 | Andy Richter Controls the Universe | 2002–2003 | 2 | 19 | Sitcom | Victor Fresco |
| Mar 27 | Greg the Bunny | 2002–2006 | 3 | 32 | Sitcom | Steven Levitan |
| Apr 30 | That '70s Musical | 2002 | — | — | Musical | |
| Jun 11 | American Idol | 2002–2016 | 15 | 555 | Singing talent show | Simon Fuller |
| Jul 17 | 30 Seconds to Fame | 2002–2003 | 2 | 16 | — | |
| Sep 14 | Stargate InfinityAnimated series | 2002–2003 | 1 | 26 | Comedy | |
| Sep 18 | Cedric the Entertainer Presents | 2002–2003 | 3 | 21 | — | |
| Sep 18 | Fastlane | 2002–2003 | 1 | 22 | Drama | McG |
| Sep 20 | Firefly | 2002–2003 | 1 | 14 | Drama | Joss Whedon |
| Sep 20 | John Doe | 2002–2003 | 1 | 21 | Drama | |
| Oct 21 | Girls Club | 2002 | 1 | 13 | Drama | David E. Kelley |
| — | Still Life | 2003–2004 | 1 | 6 | — | |
| Jan 6 | Joe Millionaire | 2003 | 1 | 6 | Reality | |
| Mar 8 | Classmates | 2003 | 2 | 96 | — | |
| Mar 9 | Oliver Beene | 2003–2004 | 2 | 24 | Sitcom | Howard Gewirtz |
| Mar 26 | Wanda at Large | 2003 | 2 | 19 | Sitcom | Lance Crouther |
| Mar 30 | The Pitts | 2003 | 1 | 7 | Sitcom | Mike Scully |
| Jun 3 | American Juniors | 2003 | 1 | 17 | Singing talent show | |
| Jun 3 | Keen Eddie | 2003 | 1 | 13 | Police procedural | J. H. Wyman |
| Jun 18 | Paradise Hotel | 2003–2019 | 3 | 54 | Reality | |
| Aug 5 | The O.C. | 2003–2007 | 4 | 92 | LGBTQ | Josh Schwartz |
| Sep 19 | Luis | 2003 | 1 | 11 | Sitcom | Will Gluck |
| Oct 20 | Skin | 2003–2005 | 1 | 8 | Drama | Jim Leonard |
| Oct 29 | A Minute with Stan Hooper | 2003 | 1 | 13 | Sitcom | Norm Macdonald |
| Oct 30 | Tru Calling | 2003–2005 | 2 | 26 | Science fiction | Jon Harmon Feldman |
| Dec 2 | The Simple Life | 2003–2007 | 5 | 55 | Reality | Jonathan Murray, Mary-Ellis Bunim |
| — | My Big Fat Obnoxious Fiance | 2004 | 3 | 7 | Reality | |
| — | The Littlest Groom | 2004 | 1 | 2 | Reality | |
| Mar 9 | Cracking Up | 2004 | 1 | 13 | Sitcom | |
| Mar 12 | Wonderfalls | 2004 | 1 | 13 | LGBTQ | Bryan Fuller |
| Jun 8 | The Jury | 2004 | 1 | 10 | Police procedural | James Yoshimura |
| Jun 14 | North Shore | 2004–2005 | 1 | 21 | Soap opera | |
| Jun 14 | The Casino | 2004 | 1 | 13 | Reality | Mark Burnett |
| Jun 16 | Method & Red | 2004 | 1 | 13 | Sitcom | |
| Jun 16 | Quintuplets | 2004–2005 | 1 | 22 | Sitcom | Mark Reisman |
| Jul 1 | Trading Spouses | 2004–2007 | 3 | 59 | Reality | |
| Nov 3 | Nanny 911 | 2004–2009 | 4 | 51 | Reality | |
| Nov 16 | House | 2004–2012 | 8 | 177 | Medical drama | David Shore |
| Jan 14 | Jonny Zero | 2005 | 1 | 13 | Drama | R. Scott Gemmill, Ken Sanzel |
| Jan 19 | Point Pleasant | 2005 | 1 | 13 | Soap opera | Marti Noxon, John J. McLaughlin |
| Feb 6 | American Dad!Animated series | 2005 | 22 | 399 | Surreal humour | Seth MacFarlane, Matt Weitzman |
| Mar 24 | Life on a Stick | 2005 | 1 | 13 | Sitcom | Victor Fresco |
| Apr 13 | Stacked | 2005–2006 | 2 | 19 | Sitcom | Steven Levitan |
| May 30 | Hell's Kitchen | 2005 | 25 | 383 | Reality | Gordon Ramsay |
| Jun 8 | The Inside | 2005 | 1 | 13 | Police procedural | Tim Minear |
| Jul 10 | The Princes of Malibu | 2005 | 1 | 6 | Reality | |
| Jul 20 | So You Think You Can Dance | 2005–2022 | 17 | 308 | Talent show | Simon Fuller |
| Aug 21 | BratzAnimated series | 2005–2007 | 2 | 40 | — | MGA Entertainment |
| Aug 29 | Prison Break | 2005–2017 | 5 | 90 | Drama | Paul Scheuring |
| Sep 8 | Reunion | 2005 | 1 | 13 | — | Jon Harmon Feldman |
| Sep 10 | G.I. Joe: Sigma 6Animated series | 2005 | — | 26 | Action | |
| Sep 11 | The War at Home | 2005–2007 | 2 | 44 | Comedy | Rob Lotterstein |
| Sep 13 | Bones | 2005–2017 | 12 | 246 | Police procedural | Hart Hanson |
| Sep 14 | Head Cases | 2005 | 1 | 7 | Drama | |
| Sep 19 | Kitchen Confidential | 2005 | 1 | 13 | Sitcom | David Hemingson |
| Sep 23 | Killer Instinct | 2005 | 1 | 13 | Drama | Josh Berman |
| Nov 19 | Alien RacersAnimated series | 2005–2006 | — | 4 | Science fiction | |
| — | Free Ride | 2006 | 1 | 6 | — | |
| Jan 18 | Skating with Celebrities | 2006 | 1 | 7 | Reality | ITV |
| Mar 15 | The Loop | 2006–2007 | 2 | 17 | Sitcom | Will Gluck |
| Aug 21 | Vanished | 2006 | 1 | 13 | Thriller | Josh Berman |
| Aug 26 | Viva Piñata | 2006–2009 | 2 | 52 | Children's | |
| Aug 29 | Celebrity Duets | 2006 | 1 | 9 | Reality | |
| Aug 30 | Justice | 2006–2007 | 1 | 13 | Drama | Jerry Bruckheimer |
| Sep 5 | Standoff | 2006–2007 | 1 | 18 | Police drama | |
| Sep 7 | 'Til Death | 2006–2010 | 4 | 81 | Sitcom | Josh Goldsmith |
| Sep 7 | Happy Hour | 2006 | 1 | 13 | Sitcom | |
| Sep 16 | Talkshow with Spike Feresten | 2006–2009 | 3 | 65 | — | Spike Feresten |
| Nov 1 | The Rich List | 2006 | 1 | 1 | Game show | |
| Jan 15 | The Rookie | 2007–2008 | 3 | 12 | — | |
| Feb 27 | Are You Smarter than a 5th Grader? | 2007–2019 | 6 | 98 | Quiz show | Mark Burnett |
| Mar 4 | The Winner | 2007 | 1 | 6 | Sitcom | Ricky Blitt |
| Mar 7 | The Wedding Bells | 2007 | 1 | 7 | Comedy-drama | David E. Kelley |
| Apr 13 | Drive | 2007 | 1 | 6 | Drama | Tim Minear |
| May 22 | On the Lot | 2007 | 1 | 16 | Reality | |
| Jul 11 | Don't Forget the Lyrics! | 2007 | — | — | Game show | |
| Sep 10 | TMZ on TVNews program | 2007 | 14 | — | Rotogravure | Harvey Levin, Jim Paratore |
| Sep 17 | K-Ville | 2007 | 1 | 11 | Drama | |
| Sep 19 | Back to You | 2007–2008 | 1 | 17 | Sitcom | Christopher Lloyd |
| Sep 19 | Kitchen Nightmares | 2007 | 9 | 112 | Cooking show | |
| Jan 13 | Terminator: The Sarah Connor Chronicles | 2008–2009 | 2 | 31 | Drama | Josh Friedman |
| Jan 23 | The Moment of Truth | 2008 | 2 | — | Quiz show | Howard Schultz |
| Mar 2 | Unhitched | 2008 | 1 | 6 | Sitcom | Kevin Barnett |
| Mar 4 | New Amsterdam | 2008 | 1 | 8 | Police procedural | Allan Loeb |
| Mar 10 | Canterbury's Law | 2008 | 1 | 6 | Drama | Dave Erickson |
| Mar 14 | The Return of Jezebel James | 2008 | 1 | 7 | Sitcom | Amy Sherman-Palladino |
| Sep 7 | Hole in the Wall | 2008–2009 | — | — | Game show | |
| Sep 9 | Fringe | 2008–2013 | 5 | 100 | Drama | Roberto Orci, Alex Kurtzman |
| Sep 10 | Do Not Disturb | 2008 | 1 | 7 | Sitcom | |
| — | Brothers | 2009 | 1 | 13 | Sitcom | |
| Jan 21 | Lie to Me | 2009–2011 | 3 | 48 | Drama | Samuel Baum |
| Feb 13 | Dollhouse | 2009–2010 | 2 | 26 | Thriller | Joss Whedon |
| Mar 31 | Osbournes Reloaded | 2009 | 1 | — | — | |
| Apr 19 | Sit Down, Shut UpAnimated series | 2009 | 1 | 13 | Sitcom | |
| May 19 | Glee | 2009–2015 | 6 | 121 | Comedy-drama | Brad Falchuk, Ryan Murphy |
| May 26 | Mental | 2009 | 1 | 13 | Drama | |
| Jul 28 | More to Love | 2009 | 1 | 9 | Reality | Mike Fleiss |
| Sep 27 | The Cleveland ShowAnimated series | 2009–2013 | 4 | 88 | Comedy | Mike Henry, Seth MacFarlane |
| Oct 11 | Million Dollar Challenge | 2009–2010 | 2 | 13 | — | |
| Nov 7 | The Wanda Sykes Show | 2009–2010 | 1 | 21 | — | Wanda Sykes |