| Premiere | Show | Years | Seasons | Episodes | Genre | Created by |
|---|---|---|---|---|---|---|
| — | Worst Case Scenarios | 2002 | 1 | 13 | Reality | |
| Oct 19 | He's a Lady | 2004 | 1 | 6 | LGBTQ | Tommy Campbell |
| Feb 6 | American Dad!Animated series | 2005 | 22 | 399 | Surreal humour | Seth MacFarlane, Matt Weitzman |
| Jun 21 | Tyler Perry's House of Payne | 2006–2012 | 8 | 254 | Drama | Tyler Perry |
| Nov 27 | 10 Items or Less | 2006–2009 | 3 | 21 | Sitcom | Nancy Hower |
| Nov 28 | My Boys | 2006–2010 | 4 | 49 | Sitcom | Betsy Thomas |
| Jul 17 | The Bill Engvall Show | 2007–2009 | 3 | 30 | Comedy | Bill Engvall |
| Nov 20 | Frank TV | 2007–2008 | 2 | 15 | — | Frank Caliendo |
| Jan 7 | Tyler Perry's Meet the Browns | 2009–2011 | 5 | 140 | Sitcom | Tyler Perry |
| Sep 23 | Cougar Town | 2009–2015 | 6 | 102 | Sitcom | Bill Lawrence |
| Nov 9 | Lopez Tonight | 2009–2011 | 2 | 286 | — | George Lopez |