| Premiere | Show | Years | Seasons | Episodes | Genre | Created by |
|---|---|---|---|---|---|---|
| Apr 3 | Between the Lions | 2000–2010 | 10 | 130 | Children's | |
| Sep 4 | Clifford the Big Red DogAnimated series | 2000–2003 | 2 | 65 | Fantasy | |
| Sep 9 | Timothy Goes to School | 2000–2001 | 2 | 26 | Animation | Rosemary Wells |
| Sep 3 | Sagwa the Chinese Siamese CatAnimated series | 2001–2002 | 1 | 40 | Children's | Amy Tan |
| Jan 19 | DragonflyTV | 2002–2008 | 7 | 72 | — | Minnesota PBS |
| Jan 21 | CyberchaseAnimated series | 2002 | 16 | 153 | Educational | |
| Sep 2 | Make Way for NoddyAnimated series | 2002–2007 | 2 | 100 | Comedy | Enid Blyton |
| Sep 1 | Clifford's Puppy Days | 2003–2006 | 3 | 63 | — | Norman Bridwell |
| Sep 7 | Jakers! The Adventures of Piggley WinksAnimated series | 2003–2007 | 3 | 52 | — | Mike Young |
| Apr 12 | Peep and the Big Wide WorldAnimated series | 2004–2011 | 5 | 55 | Comedy | |
| Jan 2 | It's a Big Big World | 2006–2010 | 2 | 47 | — | Mitchell Kriegman |
| Sep 4 | Curious GeorgeAnimated series | 2006–2022 | 15 | 198 | Comedy | Margret Rey |
| Sep 10 | SeeMore's Playhouse | 2006–2012 | 2 | 30 | — | |
| Sep 3 | Super Why!Animated series | 2007–2016 | 3 | 103 | Music | Angela Santomero |
| Sep 3 | WordGirlAnimated series | 2007–2015 | 8 | 130 | Comedy | |
| Jan 6 | biz KID$ | 2008–2017 | 5 | 65 | — | |
| Sep 1 | Martha SpeaksAnimated series | 2008–2014 | 6 | 96 | Comedy | Susan Meddaugh |
| Sep 1 | Sid The Science KidAnimated series | 2008–2013 | 2 | 54 | Children's | Jim Henson |
| Sep 7 | Dinosaur TrainAnimated series | 2009–2020 | 5 | 100 | Fantasy | Craig Bartlett |