| Premiere | Show | Years | Seasons | Episodes | Genre | Created by |
|---|---|---|---|---|---|---|
| Oct 25 | As Told by GingerAnimated series | 2000–2016 | 3 | 60 | Comedy-drama | Emily Kapnek |
| Sep 2 | Kaput & ZöskyAnimated series | 2002–2003 | 2 | 26 | — | |
| Apr 3 | Danny PhantomAnimated series | 2004–2007 | 3 | 53 | Children's | Butch Hartman |
| Jan 6 | Kappa Mikey | 2006–2008 | 2 | 52 | Anime-influenced animation | Larry Schwarz |
| Oct 7 | Edgar & EllenAnimated series | 2007–2008 | 2 | 24 | Comedy | Charles Ogden |
| May 2 | Speed Racer: The Next GenerationAnimated series | 2008–2013 | 2 | 52 | Children's | Larry Schwarz |
| Jun 27 | Three DeliveryAnimated series | 2008–2009 | 1 | 26 | Action | Larry Schwarz |
| Oct 4 | Making FiendsAnimated series | 2008 | 1 | 6 | — | Amy Winfrey |
| Dec 6 | Random! Cartoons | 2008–2009 | — | 13 | — | Fred Seibert |
| Jan 23 | Wolverine and the X-MenAnimated series | 2009 | 1 | 26 | Comedy | Craig Kyle |