| — | Titans | 2000 | 1 | 13 | Soap opera | Charles Pratt Jr. |
| Feb 5 | The Others | 2000 | 1 | 13 | Science fiction | John Brancato, Michael Ferris |
| Feb 20 | Little RichardMiniseries | 2000 | — | — | Biographical | |
| Mar 9 | God, the Devil and BobAnimated series | 2000 | 1 | 13 | Animated sitcom | Matthew Carlson |
| Mar 23 | Battery Park | 2000 | 1 | 7 | Sitcom | |
| Mar 23 | Daddio | 2000 | 2 | 18 | Sitcom | |
| May 7 | Jason and the ArgonautsMiniseries | 2000 | — | — | Fantasy | |
| Jun 6 | M.Y.O.B. | 2000 | 1 | 8 | Comedy | Don Roos |
| Jul 24 | Mysterious Ways | 2000–2002 | 2 | 44 | Science fiction | Peter O'Fallon |
| Aug 8 | Sammy | 2000 | 1 | 2 | — | David Spade |
| Sep 23 | Just Deal | 2000–2002 | 3 | 39 | Comedy-drama | |
| Oct 2 | Deadline | 2000–2001 | 1 | 13 | Drama | Dick Wolf |
| Oct 2 | Megyn Kelly TodayNews program | 2000–2017 | 1 | 282 | Talk show | |
| Oct 2 | Tucker | 2000 | 1 | 13 | Teen sitcom | |
| Oct 8 | Ed | 2000–2004 | 4 | 83 | Comedy-drama | Rob Burnett, Jon Beckerman |
| Oct 24 | The Michael Richards Show | 2000 | 1 | 9 | Sitcom | Spike Feresten |
| Oct 26 | Cursed | 2000–2001 | 1 | 17 | Sitcom | |
| Nov 12 | In the BeginningMiniseries | 2000 | — | 2 | Drama | |
| Nov 14 | DAG | 2000–2001 | 1 | 17 | Sitcom | Jack Burditt |
| Jan 9 | Three Sisters | 2001–2002 | 2 | 35 | Sitcom | |
| Mar 19 | First Years | 2001 | 1 | 9 | — | |
| Mar 26 | The Fighting Fitzgeralds | 2001 | 1 | 10 | Sitcom | Brian Burns |
| Jun 5 | Kristin | 2001 | 1 | 13 | Sitcom | |
| Jun 19 | Go Fish | 2001 | 1 | 5 | Sitcom | Adam Herz |
| Jul 24 | The Downer Channel | 2001 | 1 | 6 | Sketch comedy | |
| Aug 4 | All About Us | 2001 | 1 | 13 | Comedy-drama | Lois Bromfield |
| Sep 4 | Lost | 2001 | — | 6 | Reality | |
| Sep 24 | Crossing Jordan | 2001–2007 | 6 | 117 | Crime | Tim Kring |
| Sep 25 | Emeril | 2001 | 1 | 11 | — | |
| Sep 27 | Inside Schwartz | 2001–2002 | 1 | 13 | Sitcom | Stephen Engel |
| Sep 30 | Law & Order: Criminal Intent | 2001–2011 | 10 | 197 | Drama | Dick Wolf |
| Sep 30 | UC: Undercover | 2001–2002 | 1 | 13 | — | |
| Oct 2 | Scrubs | 2001–2010 | 10 | 187 | Medical drama | Bill Lawrence |
| Oct 6 | Sk8 | 2001–2002 | 1 | 13 | Teen drama | Thomas W. Lynch |
| — | Young Arthur | 2002 | — | — | Medieval | |
| Jan 8 | Imagine That | 2002 | 1 | 6 | Sitcom | |
| Jan 8 | Last Call with Carson Daly | 2002–2019 | 17 | 2,000 | — | |
| Feb 26 | Watching Ellie | 2002–2003 | 2 | 19 | Sitcom | Brad Hall |
| Feb 28 | Leap of Faith | 2002 | 1 | 6 | Sitcom | Jenny Bicks |
| Jun 16 | Crime & Punishment | 2002–2004 | 3 | 26 | Reality | Bill Guttentag |
| Jun 17 | Dog Eat Dog | 2002–2003 | 2 | 26 | Game show | |
| Jul 15 | She Spies | 2002–2004 | 2 | 40 | Action | Craig Van Sickle |
| Jul 22 | Meet My Folks | 2002–2003 | — | 20 | Reality | Bruce Nash |
| Aug 1 | The Rerun Show | 2002 | 1 | 7 | Sketch comedy | |
| Sep 24 | Hidden Hills | 2002–2003 | 1 | 18 | Sitcom | Peter Segal |
| Sep 24 | In-Laws | 2002–2003 | 1 | 15 | Sitcom | |
| Sep 26 | Good Morning, Miami | 2002–2003 | 2 | 40 | Sitcom | David Kohan |
| Sep 29 | Boomtown | 2002–2003 | 2 | 24 | Drama | Graham Yost |
| Sep 29 | Our Generation | 2002–2005 | 3 | 61 | Drama | Jonathan Prince |
| Oct 1 | Operation Junkyard | 2002 | — | — | Action | Mina Crandon |
| Oct 5 | Endurance | 2002–2008 | 6 | 86 | Reality | J.D. Roth |
| Oct 5 | Scout's Safari | 2002–2004 | 2 | 26 | — | Thomas W. Lynch |
| Jan 10 | Mister Sterling | 2003 | 1 | 10 | — | Lawrence O'Donnell |
| Feb 2 | Kingpin | 2003 | 1 | 6 | — | David Mills |
| Feb 4 | A.U.S.A. | 2003 | 1 | 12 | Sitcom | Richard Appel |
| Mar 8 | Nashville Star | 2003–2008 | — | 52 | Singing talent show | |
| Mar 28 | America's Most Talented Kid | 2003–2006 | 3 | 10 | Reality | |
| Apr 19 | Hunter | 2003 | 1 | 5 | Detective | Frank Lupo |
| Jun 1 | Last Comic Standing | 2003–2015 | 9 | 76 | Reality | |
| Jun 2 | For Love or Money | 2003–2004 | 4 | 25 | Reality | |
| Jul 14 | Who Wants to Marry My Dad? | 2003–2004 | 2 | 11 | Reality | |
| Sep 7 | Fear Factor | 2003 | 8 | 184 | Game show | |
| Sep 9 | Happy Family | 2003–2004 | 1 | 22 | Sitcom | |
| Sep 9 | Whoopi | 2003–2004 | 1 | 22 | Sitcom | Bonnie Turner |
| Sep 22 | Las Vegas | 2003–2008 | 5 | 106 | Comedy-drama | Gary Scott Thompson |
| Sep 25 | Coupling | 2003 | 1 | 10 | Sitcom | Steven Moffat |
| Sep 26 | Miss Match | 2003 | 1 | 18 | Comedy-drama | Darren Star |
| Sep 28 | The Lyon's Den | 2003 | 1 | 13 | — | Remi Aubuchon |
| Nov 1 | Kenny the Shark | 2003–2005 | 2 | 26 | — | |
| Nov 3 | Average Joe | 2003–2005 | 4 | 25 | Reality | |
| Dec 2 | The Tracy Morgan Show | 2003–2004 | 1 | 18 | Sitcom | David M. Israel |
| Dec 25 | WWE Tribute to the Troops | 2003 | — | 11 | Sports entertainment | Vince McMahon |
| Jan 8 | The Apprentice | 2004–2017 | 15 | 188 | Reality | Mark Burnett |
| May 2 | 10.5Miniseries | 2004 | 1 | 2 | Disaster | |
| Jun 3 | Come to Papa | 2004 | 1 | 4 | Comedy | |
| Jun 14 | Next Action Star | 2004 | 1 | 10 | Reality | |
| Aug 31 | Father of the PrideAnimated series | 2004–2005 | 1 | 15 | Animated sitcom | Jeffrey Katzenberg |
| Sep 1 | Hawaii | 2004 | 1 | 8 | Drama | Jeff Eastin |
| Sep 9 | Joey | 2004–2006 | 2 | 46 | Comedy | Shana Goldberg-Meehan, Scott Silveri |
| Sep 9 | Medical Investigation | 2004–2005 | 1 | 20 | Drama | |
| Sep 13 | LAX | 2004–2005 | 1 | 13 | Drama | |
| Oct 2 | Darcy's Wild Life | 2004–2006 | 2 | 33 | Comedy | |
| Oct 19 | The Biggest Loser | 2004–2016 | 18 | 248 | Reality | |
| Nov 8 | $25 Million Dollar Hoax | 2004 | — | 3 | Reality | |
| Nov 8 | Days of Our Lives | 2004 | — | 15,609 | Soap opera | Betty Corday, Ted Corday |
| Jan 3 | Medium | 2005–2011 | 7 | 130 | Thriller | Glenn Gordon Caron |
| Jan 4 | Committed | 2005 | 1 | 13 | Sitcom | |
| Feb 8 | Most Outrageous Moments | 2005–2009 | — | 21 | Reality | |
| Mar 3 | Law & Order: Trial by Jury | 2005–2006 | 1 | 13 | Drama | Dick Wolf |
| Mar 7 | The Contender | 2005–2018 | 4 | 50 | Reality | |
| Mar 24 | The Office | 2005–2013 | 9 | 204 | Mockumentary | |
| Apr 13 | RevelationsMiniseries | 2005 | — | 6 | Mystery | David Seltzer |
| May 16 | HerculesMiniseries | 2005 | 1 | 2 | Drama | Charles Edward Pogue |
| Jul 9 | Time Warp TrioAnimated series | 2005–2006 | 1 | 26 | Science fiction | Jon Scieszka |
| Jul 28 | The Law Firm | 2005 | 1 | 8 | Reality | |
| Aug 16 | Tommy Lee Goes to College | 2005 | — | 6 | Reality | BT |
| Sep 19 | Surface | 2005–2006 | 1 | 16 | Science fiction | Jonas Pate |
| Sep 20 | My Name Is Earl | 2005–2009 | 4 | 96 | Sitcom | Greg Garcia |
| Sep 21 | E-Ring | 2005–2006 | 1 | 22 | Drama | David McKenna |
| Sep 21 | The Apprentice: Martha Stewart | 2005 | — | 13 | Reality | Mark Burnett |
| Sep 23 | Inconceivable | 2005 | 1 | 9 | Drama | Oliver Goldstick |
| Sep 23 | Three Wishes | 2005 | 1 | 10 | Reality | Andrew Glassman |
| Dec 19 | Deal or No Deal | 2005–2019 | 5 | 234 | Game show | |
| Jan 5 | Four Kings | 2006 | 1 | 13 | Comedy | David Kohan |
| Jan 6 | The Book of Daniel | 2006 | 1 | 8 | LGBTQ | Jack Kenny |
| Mar 3 | Conviction | 2006 | 1 | 13 | Drama | Dick Wolf |
| Mar 28 | Teachers | 2006 | 1 | 6 | Sitcom | |
| Apr 17 | Celebrity Cooking Showdown | 2006 | 1 | 4 | Reality | Glenn Gordon Caron |
| May 21 | 10.5: ApocalypseMiniseries | 2006 | 1 | 2 | Disaster | |
| Jun 8 | Windfall | 2006 | 1 | 13 | Romance | |
| Jun 18 | Treasure Hunters | 2006 | — | — | Reality | |
| Jun 21 | America's Got Talent | 2006 | 19 | 459 | Music | Simon Cowell |
| Jun 21 | Got Talent | 2006 | — | — | Reality | Simon Cowell |
| Jul 13 | The Office: The Accountants | 2006 | 1 | 10 | Mockumentary | |
| Sep 10 | Football Night in America | 2006 | 9 | 228 | Pre-game show | |
| Sep 18 | Studio 60 on the Sunset Strip | 2006–2007 | 1 | 22 | Comedy-drama | Aaron Sorkin |
| Sep 20 | Kidnapped | 2006–2007 | 1 | 13 | Drama | Jason Smilovic |
| Sep 25 | Heroes | 2006–2010 | 4 | 77 | Drama | Tim Kring |
| Oct 3 | Friday Night Lights | 2006–2011 | 5 | 76 | Drama | Peter Berg |
| Oct 11 | 30 Rock | 2006–2013 | 7 | 138 | Satire | Tina Fey |
| Oct 11 | Twenty Good Years | 2006 | 1 | 9 | Sitcom | |
| Oct 13 | 1 vs. 100 | 2006–2008 | 3 | 68 | Game show | |
| Dec 18 | Identity | 2006–2007 | — | 12 | Game show | |
| Jan 1 | Poker After Dark | 2007–2011 | 7 | 474 | — | |
| Jan 7 | Grease: You're the One That I Want! | 2007 | 1 | 11 | Reality | BBC Worldwide |
| Feb 26 | The Black Donnellys | 2007 | 1 | 13 | Drama | Paul Haggis, Robert Moresco |
| Feb 28 | Afterworld | 2007 | — | 130 | Science fiction | |
| Mar 5 | Dame chocolate | 2007 | — | 150 | Drama | Perla Farías |
| Mar 15 | Andy Barker, P.I. | 2007 | 1 | 6 | Sitcom | Conan O'Brien |
| Mar 15 | Raines | 2007 | 1 | 7 | Police procedural | Graham Yost |
| Apr 9 | Thank God You're Here | 2007 | 1 | 7 | — | Working Dog Productions |
| Apr 23 | The Real Wedding Crashers | 2007 | 1 | 6 | Reality | |
| Jun 18 | Age of Love | 2007 | 1 | 8 | Reality | |
| Sep 10 | Today with Jenna & Friends | 2007 | 11 | — | Talk show | |
| Sep 24 | Chuck | 2007–2012 | 5 | 91 | Drama | Josh Schwartz |
| Sep 24 | Journeyman | 2007 | 1 | 13 | Drama | |
| Sep 26 | Bionic Woman | 2007 | 1 | 8 | Science fiction | David Eick |
| Sep 26 | Life | 2007–2009 | 2 | 32 | Drama | Rand Ravich |
| Oct 24 | Phenomenon | 2007–2011 | 1 | 5 | Reality | |
| Dec 17 | Clash of the Choirs | 2007 | 1 | 4 | Reality | Friday TV |
| Dec 28 | The Singing Bee | 2007–2012 | 5 | — | Game show | |
| Jan 3 | The Celebrity Apprentice | 2008–2017 | 7 | 83 | Reality | |
| Jan 6 | American Gladiators | 2008 | 2 | 21 | Game show | |
| Feb 7 | Lipstick Jungle | 2008–2009 | 2 | 20 | Comedy-drama | |
| Feb 17 | Knight Rider | 2008–2009 | 1 | 17 | Action | Glen A. Larson |
| Feb 18 | My Dad Is Better Than Your Dad | 2008 | 1 | 60 | Game show | Mark Burnett |
| Feb 22 | Amne$ia | 2008 | — | 8 | — | Mark Burnett |
| Feb 26 | Quarterlife | 2008 | 1 | 6 | Comedy-drama | Marshall Herskovitz |
| Jun 11 | Celebrity Circus | 2008 | 1 | 6 | Reality | |
| Jun 24 | Celebrity Family Feud | 2008 | 7 | 65 | Game show | Mark Goodson |
| Jun 25 | The Baby Borrowers | 2008 | 1 | 6 | Reality | |
| Aug 18 | Gemini Division | 2008 | 1 | 50 | Drama | |
| Aug 25 | America's Toughest Jobs | 2008 | 1 | 10 | Reality | |
| Oct 9 | Kath & Kim | 2008–2009 | 1 | 17 | Sitcom | |
| Oct 9 | Saturday Night Live Weekend Update Thursday | 2008–2017 | 3 | 8 | Comedy | Lorne Michaels |
| Oct 13 | My Own Worst Enemy | 2008 | 1 | 9 | Action | Jason Smilovic |
| Oct 17 | Crusoe | 2008–2009 | 1 | 13 | Adventure | Stephen Gallagher |
| Oct 20 | The Mask of Analia | 2008–2009 | 1 | 178 | Romance | |
| Dec 16 | Momma's Boys | 2008–2009 | 1 | 11 | Reality | Ryan Seacrest |
| Jan 4 | Superstars of Dance | 2009 | 1 | 5 | Reality | Nigel Lythgoe |
| Jan 9 | Howie Do It | 2009 | 1 | 20 | Reality | |
| Mar 2 | Late Night with Jimmy Fallon | 2009–2014 | 5 | 969 | Late-night talk show | Jimmy Fallon |
| Mar 11 | The Chopping Block | 2009 | 1 | 8 | — | |
| Mar 15 | Kings | 2009 | 1 | 13 | Drama | Michael Green |
| Apr 9 | Parks and Recreation | 2009–2015 | 7 | 125 | Sitcom | Michael Schur, Greg Daniels |
| Apr 9 | Southland | 2009–2013 | 5 | 43 | Police procedural | Ann Biderman |
| Jun 1 | The Tonight Show with Conan O'Brien | 2009–2010 | — | 146 | Talk show | Sylvester Weaver |
| Jun 24 | The Philanthropist | 2009 | 1 | 8 | Drama | Tom Fontana |
| Jul 7 | The Great American Road Trip | 2009 | 1 | 8 | Reality | |
| Jul 12 | MeteorMiniseries | 2009 | — | 2 | Science fiction | |
| Jul 14 | CtrlWeb series | 2009 | 1 | 10 | — | |
| Aug 1 | Face the Ace | 2009–2010 | 1 | 7 | Reality | |
| Sep 14 | The Jay Leno Show | 2009–2010 | 1 | 95 | — | Jay Leno |
| Sep 17 | Community | 2009–2015 | 6 | 110 | College life | Dan Harmon |
| Sep 23 | Mercy | 2009–2010 | 1 | 22 | Drama | Liz Heldens |
| Sep 23 | Trauma | 2009–2010 | 1 | 18 | Drama | |
| Oct 5 | Let's Make a Deal | 2009 | 6 | 1,395 | Game show | |
| Dec 14 | The Sing-Off | 2009–2014 | 5 | 28 | Talent show | |