| Premiere | Show | Years | Seasons | Episodes | Genre | Created by |
|---|---|---|---|---|---|---|
| — | The Idiot Box | 1990–1991 | 1 | 6 | — | Alex Winter |
| — | 120 Minutes | 1991 | — | — | — | Dave Kendall |
| Jun 2 | Liquid TelevisionAnimated series | 1991–1994 | 3 | 27 | — | Japhet Asher |
| Sep 1 | Æon FluxAnimated series | 1991–1995 | 3 | 16 | Biopunk | Peter Chung |
| Jan 25 | MTV Sports | 1992–1997 | — | — | — | |
| Mar 1 | Al TV | 1992–2006 | — | 10 | Comedy | |
| May 21 | The Real World | 1992–2019 | 33 | 614 | Docu-soap | |
| Jun 29 | The Grind | 1992–1997 | — | 1,410 | Music | |
| Mar 8 | Beavis and Butt-HeadAnimated series | 1993–2011 | 11 | 202 | Youth | Mike Judge |
| Oct 25 | The Jon Stewart Show | 1993–1995 | 2 | 160 | Talk show | Jon Stewart |
| Dec 17 | The State | 1993–1995 | 4 | 28 | Sketch comedy | |
| — | Squirt TV | 1994–1996 | — | — | — | Jake Fogelnest |
| Feb 14 | Trashed | 1994 | — | 50 | Game show | |
| Jun 9 | Dead at 21 | 1994 | 1 | 13 | Science fiction | |
| Aug 15 | The Brothers GruntAnimated series | 1994–1995 | 4 | 35 | Adult animation | Danny Antonucci |
| Sep 1 | The HeadAnimated series | 1994–1996 | 3 | 14 | Science fiction | Eric Fogel |
| Apr 8 | The Maxx | 1995 | — | 13 | Comedy-drama | Sam Kieth |
| Jun 5 | Singled Out | 1995–1998 | — | — | Game show | |
| Jul 19 | Road Rules | 1995–2007 | 14 | 220 | Reality | Mary-Ellis Bunim |
| May 13 | Buzzkill | 1996 | 1 | 7 | Reality | Dave Sheridan |
| — | Cartoon SushiAnimated series | 1997–1998 | 1 | — | Adult animation | Danny Antonucci |
| — | The Sifl and Olly Show | 1997–1999 | 3 | — | Comedy | Liam Lynch |
| Mar 3 | DariaAnimated series | 1997–2002 | 5 | 67 | Comedy | Glenn Eichler |
| Mar 5 | The Jenny McCarthy Show | 1997 | — | 6 | Comedy | |
| Jun 16 | Oddville, MTV | 1997–1999 | — | 65 | Comedy | |
| Jul 13 | Apartment 2F | 1997 | 1 | 13 | Sitcom | |
| Sep 10 | Austin Stories | 1997–1998 | 1 | 12 | Sitcom | |
| Mar 24 | True Life | 1998–2017 | 21 | 346 | Documentary | |
| May 14 | Celebrity DeathmatchAnimated series | 1998–2007 | 6 | 93 | Sport | Eric Fogel |
| May 25 | Say What? Karaoke | 1998–2003 | — | — | Game show | |
| Jul 1 | The Challenge | 1998 | 36 | 374 | Reality | Mary-Ellis Bunim |
| Jul 23 | Super Adventure Team | 1998 | 1 | 6 | Science fiction | |
| Sep 14 | Total Request Live | 1998–2018 | 19 | 2,247 | Music chart | |
| Mar 8 | Station Zero | 1999 | 1 | 20 | — | |
| Jul 11 | Making the Video | 1999 | 14 | 240 | — | MTV |
| Jul 26 | Undressed | 1999–2002 | 6 | 222 | LGBTQ | Roland Joffé |
| Aug 3 | DowntownAnimated series | 1999 | 1 | 13 | Animated sitcom | Chris Prynoski |