| Feb 26 | The WeekendersAnimated series | 2000–2004 | 2 | 39 | Comedy | Doug Langdale |
| Mar 22 | Then Came You | 2000 | 1 | 13 | Sitcom | |
| Mar 24 | Making the Band | 2000–2009 | 12 | 142 | Reality | Lou Pearlman |
| Mar 30 | Wonderland | 2000 | 1 | 8 | Medical drama | Peter Berg |
| Apr 11 | Talk to Me | 2000 | 1 | 5 | — | |
| Apr 30 | Arabian NightsMiniseries | 2000 | — | 2 | Fantasy | |
| May 31 | Clerks: The Animated SeriesAnimated series | 2000–2002 | 1 | 6 | Comedy | Kevin Smith |
| Aug 30 | BattleBots | 2000 | 12 | 152 | Robot competition | |
| Sep 9 | Teacher's PetAnimated series | 2000–2002 | 3 | 40 | Animated sitcom | Bill Steinkellner, Cheri Steinkellner |
| Oct 2 | Buzz Lightyear of Star CommandAnimated series | 2000–2001 | 2 | 62 | Fantasy | |
| Oct 6 | Madigan Men | 2000 | 1 | 12 | Sitcom | |
| Oct 6 | The Trouble With Normal | 2000 | 1 | 13 | Sitcom | |
| Oct 10 | Gideon's Crossing | 2000–2001 | 1 | 20 | Drama | Paul Attanasio |
| Oct 10 | The Geena Davis Show | 2000–2001 | 1 | 22 | Sitcom | Terri Minsky |
| Nov 5 | The Growing Pains Movie | 2000 | — | — | Comedy | |
| Dec 8 | Dot Comedy | 2000 | 1 | — | Comedy | |
| — | Two Expert Thieves | 2001–2005 | 1 | 10 | — | |
| Jan 9 | The Mole | 2001–2008 | 5 | 45 | Reality | |
| Jan 13 | Disney's House of MouseAnimated series | 2001–2003 | 3 | 52 | Children's | |
| Feb 3 | Lloyd in SpaceAnimated series | 2001–2004 | 4 | 39 | Children's | |
| Mar 14 | The Job | 2001–2002 | 2 | 19 | Sitcom | Denis Leary |
| Mar 27 | What About Joan? | 2001 | 2 | 21 | Sitcom | |
| Mar 28 | My Wife and Kids | 2001–2005 | 5 | 123 | Sitcom | Don Reo |
| May 20 | Anne Frank: The Whole StoryMiniseries | 2001 | 1 | 2 | War | |
| Jun 13 | The Beast | 2001 | 1 | 6 | Drama | Kario Salem |
| Jun 20 | You Don't Know Jack | 2001 | 1 | 6 | — | |
| Aug 8 | The Wayne Brady Show | 2001–2004 | 3 | 434 | Variety show | |
| Sep 25 | Philly | 2001–2002 | 1 | 22 | Drama | Steven Bochco |
| Sep 26 | According to Jim | 2001–2009 | 8 | 182 | Sitcom | Tracy Newman |
| Sep 30 | Alias | 2001–2006 | 5 | 105 | Science fiction | J. J. Abrams |
| Oct 2 | Bob Patterson | 2001 | 1 | 10 | — | Jason Alexander |
| Oct 2 | Scrubs | 2001–2010 | 10 | 187 | Medical drama | Bill Lawrence |
| Oct 20 | Mary-Kate and Ashley in Action!Animated series | 2001–2002 | 1 | 26 | — | |
| — | WidowsMiniseries | 2002 | — | 4 | Crime | Lynda La Plante |
| Jan 20 | Teamo SupremoAnimated series | 2002 | 3 | 39 | Comedy | |
| Jan 27 | Rose RedMiniseries | 2002 | 1 | 3 | Horror | Stephen King |
| Feb 9 | Power Rangers Wild Force | 2002 | 1 | 40 | Tokusatsu | Haim Saban |
| Mar 25 | The Bachelor | 2002 | 23 | 239 | Reality | Mike Fleiss |
| Mar 26 | The Court | 2002 | 1 | 6 | Legal drama | Oliver Goldstick |
| Mar 27 | George Lopez | 2002–2007 | 6 | 120 | Sitcom | |
| Mar 27 | Wednesday 9:30 (8:30 Central) | 2002 | 1 | 12 | Sitcom | Peter Tolan |
| Jun 18 | Houston Medical | 2002 | 1 | 6 | Documentary | |
| Sep 14 | Fillmore!Animated series | 2002–2004 | 2 | 26 | Children's | Scott Gimple |
| Sep 17 | 8 Simple Rules | 2002–2005 | 3 | 76 | Sitcom | |
| Sep 17 | Life with Bonnie | 2002–2004 | 2 | 44 | Comedy | Bonnie Hunt |
| Sep 17 | Push, Nevada | 2002 | 1 | 7 | — | Ben Affleck |
| Sep 25 | MDs | 2002 | 1 | 11 | Medical drama | |
| Sep 27 | That Was Then | 2002 | 1 | 5 | Drama | |
| Oct 1 | Less Than Perfect | 2002–2006 | 4 | 81 | Sitcom | Terri Minsky |
| Nov 28 | Dinotopia | 2002 | 1 | 12 | Science fiction | |
| Dec 11 | Extreme Makeover | 2002–2007 | 4 | 54 | Docu-soap | Howard Schultz |
| Jan 8 | The Bachelorette | 2003 | 11 | 62 | Dating game show | |
| Jan 26 | Jimmy Kimmel Live! | 2003 | 23 | 3,588 | Talk show | Jimmy Kimmel |
| Jan 27 | Miracles | 2003 | 1 | 13 | Drama | Michael Petroni |
| Jan 27 | Veritas: The Quest | 2003 | 1 | 13 | Treasure hunt | Patrick Massett |
| Feb 2 | Dragnet | 2003–2004 | 2 | 22 | Crime | Dick Wolf |
| Feb 13 | Are You Hot? | 2003 | 1 | 6 | Reality | |
| Feb 15 | Power Rangers: Ninja Storm | 2003 | 1 | 38 | Tokusatsu | |
| Mar 12 | All American Girl | 2003 | 1 | 9 | Reality | |
| Mar 28 | Regular Joe | 2003 | 1 | 13 | Sitcom | |
| Apr 1 | Lost at Home | 2003 | 1 | 4 | — | |
| May 24 | WNBA on ABC | 2003 | — | — | — | |
| Aug 6 | The Real Roseanne Show | 2003 | 1 | 2 | Reality | |
| Sep 18 | Threat Matrix | 2003–2004 | 1 | 16 | Drama | |
| Sep 23 | I'm with Her | 2003–2004 | 1 | 22 | Sitcom | Chris Henchy |
| Sep 26 | Hope & Faith | 2003–2006 | 3 | 73 | Comedy | Joanna Johnson |
| Sep 28 | 10-8 | 2003–2004 | 1 | 15 | Drama | |
| Oct 1 | It's All Relative | 2003–2004 | 1 | 22 | Comedy | Anne Flett-Giordano |
| Oct 1 | Karen Sisco | 2003 | 1 | 10 | Drama | Elmore Leonard |
| Oct 3 | Married to the Kellys | 2003–2004 | 1 | 22 | Sitcom | |
| Nov 3 | Extreme Makeover: Home Edition | 2003–2012 | 9 | 200 | Reality | |
| Dec 2 | Line of Fire | 2003–2004 | 1 | 13 | Crime | Rod Lurie |
| — | The Mystery of Natalie WoodMiniseries | 2004 | — | — | Biographical | |
| Feb 14 | Power Rangers Dino Thunder | 2004 | 1 | 38 | Tokusatsu | |
| Feb 21 | ABC Saturday Movie of the Week | 2004 | 12 | 178 | Anthology | |
| Mar 3 | Kingdom Hospital | 2004 | 1 | 13 | Drama | Stephen King |
| Mar 19 | The D.A. | 2004 | 1 | 4 | Legal drama | James Duff |
| Jul 18 | The Days | 2004 | 1 | 6 | — | American Broadcasting Company |
| Sep 13 | The Benefactor | 2004 | 1 | 6 | Reality | |
| Sep 21 | Rodney | 2004–2006 | 2 | 44 | Sitcom | |
| Sep 22 | Lost | 2004–2010 | 6 | 121 | Drama | J. J. Abrams, Damon Lindelof |
| Sep 24 | Complete Savages | 2004–2005 | 1 | 19 | Teen sitcom | Mike Scully |
| Sep 26 | Wife Swap | 2004–2010 | — | — | Reality | |
| Oct 3 | Boston Legal | 2004–2008 | 5 | 101 | Satire | David E. Kelley |
| Oct 3 | Desperate Housewives | 2004–2012 | 8 | 180 | Soap opera | Marc Cherry |
| Oct 7 | Life as We Know It | 2004–2005 | 1 | 13 | Drama | Jeff Judah |
| Nov 1 | Extreme Makeover: Home Edition: How'd They Do That? | 2004–2005 | 1 | 17 | Reality | |
| Feb 5 | Power Rangers S.P.D. | 2005 | 1 | 38 | Police drama | |
| Mar 8 | Blind Justice | 2005 | 1 | 13 | Drama | Steven Bochco |
| Mar 13 | Jake in Progress | 2005–2006 | 2 | 21 | Sitcom | |
| Mar 26 | Little House on the PrairieMiniseries | 2005 | — | 6 | Drama | |
| Mar 27 | Grey's Anatomy | 2005 | 22 | 466 | Medical drama | Shonda Rhimes |
| Mar 30 | Eyes | 2005 | 1 | 12 | Drama | John McNamara |
| May 31 | Freddie | 2005–2006 | 1 | 22 | Sitcom | |
| Jun 1 | Dancing with the Stars | 2005 | 29 | 459 | Talent show | |
| Jun 6 | The Scholar | 2005 | — | — | Reality | |
| Jun 28 | Empire | 2005 | 1 | 6 | — | |
| Aug 14 | My Kind of Town | 2005 | 1 | 4 | — | |
| Sep 21 | Invasion | 2005–2006 | 1 | 22 | Science fiction | Shaun Cassidy |
| Sep 27 | Commander in Chief | 2005–2006 | 1 | 18 | Drama | Rod Lurie |
| Sep 29 | Night Stalker | 2005 | 1 | 10 | Thriller | Frank Spotnitz |
| Oct 7 | Hot Properties | 2005 | 1 | 13 | Sitcom | Suzanne Martin |
| — | Secrets of a Small Town | 2006 | — | 1 | — | Charles Pratt Jr. |
| Jan 1 | In Justice | 2006 | 1 | 13 | Drama | Michelle King |
| Jan 9 | Emily's Reasons Why Not | 2006 | 1 | 7 | Sitcom | |
| Jan 12 | Crumbs | 2006 | 1 | 13 | Sitcom | Marco Pennette |
| Jan 27 | The Emperor's New SchoolAnimated series | 2006–2008 | 2 | 52 | Children's | Mark Dindal |
| Mar 7 | Sons & Daughters | 2006 | 1 | 11 | Sitcom | Fred Goss |
| Mar 16 | American Inventor | 2006–2007 | 2 | 19 | Reality | Peter Jones |
| Mar 22 | The Evidence | 2006 | 1 | 8 | Drama | |
| Apr 10 | The Ten CommandmentsMiniseries | 2006 | 1 | 2 | Drama | |
| Apr 16 | What About Brian? | 2006–2007 | 2 | 24 | Comedy-drama | Dana Stevens |
| Jun 22 | Master of Champions | 2006 | — | 6 | Reality | |
| Jul 31 | One Ocean View | 2006 | 1 | 2 | Reality | |
| Sep 10 | The Path to 9/11Miniseries | 2006 | — | 2 | Drama | |
| Sep 12 | Men in Trees | 2006–2008 | 2 | 36 | Comedy-drama | Jenny Bicks |
| Sep 21 | Six Degrees | 2006–2007 | 1 | 13 | Drama | Stu Zicherman |
| Sep 24 | Brothers & Sisters | 2006–2011 | 5 | 109 | Drama | Jon Robin Baitz |
| Sep 26 | Help Me Help You | 2006 | 1 | 13 | Sitcom | |
| Sep 28 | Ugly Betty | 2006–2010 | 4 | 85 | Comedy-drama | Fernando Gaitán Salom |
| Oct 4 | The Nine | 2006–2007 | 1 | 13 | Mystery | Hank Steinberg |
| Nov 15 | Day Break | 2006–2007 | 1 | 13 | Fantasy | Paul Zbyszewski |
| Nov 28 | Big Day | 2006–2007 | 1 | 13 | Sitcom | Josh Goldsmith |
| Jan 3 | In Case of Emergency | 2007 | 1 | 13 | Sitcom | |
| Jan 3 | The Knights of Prosperity | 2007 | 1 | 13 | Sitcom | Rob Burnett, Jon Beckerman |
| Feb 26 | Power Rangers Operation Overdrive | 2007 | 1 | 32 | Tokusatsu | |
| Mar 15 | October Road | 2007–2008 | 2 | 19 | Drama | Josh Appelbaum, André Nemec |
| May 10 | Traveler | 2007 | 1 | 8 | Drama | |
| May 18 | National Bingo Night | 2007 | 1 | 6 | — | Andrew Glassman |
| May 28 | The Ex-Wives Club | 2007 | — | 5 | Reality | |
| May 30 | The Next Best Thing | 2007 | — | 8 | Reality | |
| Jun 7 | Fast Cars and Superstars: The Gillette Young Guns Celebrity Race | 2007 | — | 7 | Reality | |
| Jun 26 | Shaq's Big Challenge | 2007 | — | 6 | Reality | |
| Jul 20 | Set for Life | 2007 | 1 | 7 | Game show | |
| Aug 4 | Masters of Science Fiction | 2007 | 1 | 6 | Science fiction | |
| Aug 6 | Fat March | 2007 | 1 | 6 | Reality | |
| Aug 15 | NASCAR in Primetime | 2007 | — | 5 | Reality | |
| Sep 26 | Dirty Sexy Money | 2007–2009 | 2 | 23 | Drama | Craig Wright |
| Sep 26 | Private Practice | 2007–2013 | 6 | 111 | Medical drama | Shonda Rhimes |
| Sep 27 | Big Shots | 2007–2008 | 1 | 11 | — | Jon Harmon Feldman |
| Oct 2 | Carpoolers | 2007–2008 | 1 | 13 | Sitcom | Bruce McCulloch |
| Oct 2 | Cavemen | 2007 | 1 | 13 | Fantasy | Joe Lawson |
| Oct 3 | Pushing Daisies | 2007–2009 | 2 | 22 | Fantasy | Bryan Fuller |
| Oct 12 | Women's Murder Club | 2007–2008 | 1 | 13 | Police procedural | Elizabeth Craft and Sarah Fain |
| Oct 15 | Samantha Who? | 2007–2009 | 2 | 35 | Sitcom | Cecelia Ahern |
| Dec 17 | Duel | 2007–2008 | 2 | 16 | Game show | |
| Jan 6 | Cashmere Mafia | 2008 | 1 | 7 | Comedy-drama | Kevin Wade |
| Jan 7 | Dance War: Bruno vs. Carrie Ann | 2008 | 1 | 7 | — | BBC Worldwide |
| Jan 31 | Eli Stone | 2008–2009 | 2 | 26 | Musical | Greg Berlanti |
| Feb 18 | Power Rangers Jungle Fury | 2008 | 1 | 32 | Tokusatsu | |
| Feb 26 | What Would You Do?News program | 2008 | 16 | 137 | News magazine | |
| Mar 2 | Here Come the Newlyweds | 2008–2009 | 2 | 14 | Reality | |
| Mar 2 | Oprah's Big Give | 2008 | 1 | 8 | Reality | Oprah Winfrey |
| Mar 18 | Miss Guided | 2008 | 1 | 7 | Sitcom | Caroline Williams |
| Apr 12 | Notes from the Underbelly | 2008 | 2 | 24 | Sitcom | Barry Sonnenfeld |
| Jun 24 | Celebrity Family Feud | 2008 | 7 | 65 | Game show | Mark Goodson |
| Jun 24 | I Survived a Japanese Game Show | 2008–2009 | 2 | 15 | Reality | |
| Jun 24 | Wipeout | 2008–2014 | 7 | 148 | Game show | Matt Kunitz |
| Jun 26 | HopkinsMiniseries | 2008 | 1 | 7 | Documentary | |
| Jun 27 | Dance Machine | 2008 | 1 | 5 | Reality | |
| Jul 20 | High School Musical: Get in the Picture | 2008 | 1 | 11 | Reality | BBC Worldwide |
| Sep 19 | The Suite Life on Deck | 2008–2011 | 3 | 71 | Teen sitcom | Danny Kallis |
| Sep 23 | Opportunity Knocks | 2008 | 1 | 3 | — | |
| Oct 9 | Life on Mars | 2008–2009 | 1 | 17 | Police procedural | |
| Jan 1 | Scrubs: InternsWeb series | 2009 | 1 | 12 | Comedy | Bill Lawrence |
| Jan 5 | True Beauty | 2009–2010 | 2 | 16 | Reality | |
| Jan 6 | Homeland Security USA | 2009 | 1 | 13 | Reality | Arnold Shapiro |
| Mar 7 | Power Rangers RPM | 2009 | 1 | 32 | Teen drama | |
| Mar 9 | Castle | 2009–2016 | 8 | 173 | Police procedural | Andrew W. Marlowe |
| Mar 18 | Better Off Ted | 2009–2010 | 2 | 26 | Black comedy | Victor Fresco |
| Mar 26 | In the Motherhood | 2009 | 1 | 7 | Sitcom | |
| Mar 31 | Cupid | 2009 | 1 | 7 | Comedy-drama | |
| Apr 6 | Surviving Suburbia | 2009 | 1 | 13 | Sitcom | |
| Apr 8 | The Unusuals | 2009 | 1 | 10 | Comedy-drama | Noah Hawley |
| May 27 | The Goode FamilyAnimated series | 2009 | 1 | 13 | Animated sitcom | Mike Judge |
| Aug 2 | Defying Gravity | 2009 | 1 | 13 | Drama | James D. Parriott |
| Aug 9 | Shark Tank | 2009–2020 | 7 | 124 | Reality | |
| Aug 18 | Shaq Vs. | 2009–2010 | 2 | 10 | Reality | |
| Sep 22 | The Forgotten | 2009–2010 | 1 | 17 | Police procedural | |
| Sep 23 | Cougar Town | 2009–2015 | 6 | 102 | Sitcom | Bill Lawrence |
| Sep 23 | Eastwick | 2009–2010 | 1 | 13 | Fantasy | |
| Sep 23 | Modern Family | 2009–2020 | 11 | 250 | Sitcom | Steven Levitan, Christopher Lloyd |
| Sep 24 | FlashForward | 2009–2010 | 1 | 22 | Drama | Brannon Braga |
| Sep 30 | Hank | 2009 | 1 | 10 | — | Tucker Cawley |
| Sep 30 | The Middle | 2009–2018 | 9 | 215 | Sitcom | |
| Nov 3 | V | 2009–2011 | 2 | 22 | Drama | Kenneth Johnson |