| Premiere | Show | Years | Seasons | Episodes | Genre | Created by |
|---|---|---|---|---|---|---|
| Jun 16 | Hot in Cleveland | 2010–2015 | 6 | 128 | Sitcom | Suzanne Martin |
| Oct 6 | Harry Loves Lisa | 2010 | 1 | 6 | Reality | |
| Jan 19 | Retired at 35 | 2011–2012 | 2 | 20 | Sitcom | |
| Jun 15 | Happily Divorced | 2011–2013 | 2 | 34 | Comedy | Fran Drescher |
| Nov 30 | The Exes | 2011–2015 | 4 | 64 | Sitcom | |
| Jun 20 | The Soul Man | 2012–2016 | 5 | 54 | Sitcom | |
| Apr 3 | Forever Young | 2013 | 1 | 6 | Reality | |
| Dec 4 | Kirstie | 2013–2014 | 1 | 12 | Sitcom | |
| Jun 4 | Jennifer Falls | 2014 | 1 | 9 | Sitcom | |
| Mar 31 | Younger | 2015–2021 | 7 | 84 | LGBTQ | Darren Star |
| Jul 15 | Impastor | 2015–2016 | 2 | 20 | Comedy | |
| Jul 15 | The Jim Gaffigan Show | 2015–2016 | 2 | 23 | Comedy-drama | |
| Jan 13 | Teachers | 2016–2019 | 3 | 50 | Comedy | |
| Jul 5 | Crashletes | 2016–2020 | 3 | 60 | — | |
| Mar 29 | Nobodies | 2017–2018 | 2 | 24 | Comedy |