| Premiere | Show | Years | Seasons | Episodes | Genre | Created by |
|---|---|---|---|---|---|---|
| Apr 1 | UndergradsAnimated series | 2001 | 1 | 13 | College life | |
| — | Made | 2002–2014 | 13 | 280 | Reality | Angie Day |
| Jun 3 | Crank Yankers | 2002 | 4 | 70 | Sitcom | Adam Carolla |
| Oct 26 | Wildboyz | 2003–2006 | 4 | 32 | Comedy | Jeff Tremaine |
| Sep 16 | Video Mods | 2004–2005 | 2 | 6 | — | |
| — | Stankervision | 2005–2006 | — | — | — | Waco O'Guin |
| Mar 11 | Wonder ShowzenAnimated series | 2005–2006 | 2 | 16 | Adult animation | |
| Jun 26 | The Andy Milonakis Show | 2005–2007 | 3 | 22 | Comedy | Andy Milonakis |
| Jul 28 | Wild 'n Out | 2005 | 8 | 313 | Comedy | Nick Cannon |
| Mar 6 | Pros vs. Joes | 2006–2010 | 5 | 46 | Reality | |
| Jun 10 | Where My Dogs At?Animated series | 2006 | 1 | 8 | Adult animation | |
| Jul 17 | Final Fu | 2006 | — | 20 | — | |
| Nov 4 | Rob & Big | 2006–2008 | 3 | 31 | Reality | |
| Nov 6 | 50 Cent: The Money and the Power | 2008–2009 | 1 | 10 | Reality |