| Premiere | Show | Years | Seasons | Episodes | Genre | Created by |
|---|---|---|---|---|---|---|
| Oct 1 | The Increasingly Poor Decisions of Todd Margaret | 2010–2016 | 3 | 18 | Sitcom | David Cross |
| Jan 21 | Onion News Network | 2011 | 2 | 20 | Magazine format | |
| Jan 21 | Portlandia | 2011–2018 | 8 | 77 | Sketch comedy | Fred Armisen |
| Jun 8 | Bunk | 2012 | 1 | 10 | — | |
| Aug 16 | Bullet in the Face | 2012 | 1 | 6 | Black comedy | |
| Apr 19 | Out ThereAnimated series | 2013 | 1 | 10 | Comedy-drama | |
| May 3 | Maron | 2013–2016 | 4 | 49 | Comedy | Marc Maron |
| Oct 18 | The Birthday Boys | 2013–2014 | 2 | 20 | Comedy | |
| Jan 9 | The Spoils of BabylonMiniseries | 2014 | 1 | 6 | Comedy | |
| Aug 7 | Garfunkel and Oates | 2014 | 1 | 8 | Sitcom | |
| Jul 8 | The Spoils Before DyingMiniseries | 2015 | 1 | 6 | Comedy | |
| Aug 20 | Documentary Now! | 2015 | 2 | 14 | Mockumentary | Fred Armisen |
| Oct 1 | Benders | 2015 | 1 | 8 | Comedy | |
| Oct 1 | Gigi Does It | 2015 | 1 | 8 | Comedy | |
| Oct 31 | Stan Against Evil | 2016–2018 | 3 | 24 | Horror | |
| Apr 5 | Brockmire | 2017–2020 | 4 | 32 | Comedy |