| Premiere | Show | Years | Seasons | Episodes | Genre | Created by |
|---|---|---|---|---|---|---|
| Mar 14 | Son of the Beach | 2000–2002 | 3 | 43 | LGBTQ | |
| Mar 12 | The Shield | 2002–2008 | 7 | 88 | Drama | Shawn Ryan |
| Apr 8 | Lucky | 2003 | 1 | 13 | Comedy | Robb Cullen |
| Jul 22 | Nip/Tuck | 2003–2010 | 6 | 100 | LGBTQ | Ryan Murphy |
| Jul 21 | Rescue Me | 2004–2011 | 7 | 93 | Comedy-drama | Denis Leary |
| Jun 15 | 30 Days | 2005–2008 | 3 | 18 | Documentary | Morgan Spurlock |
| Jul 27 | Over There | 2005–2006 | 1 | 13 | Drama | Chris Gerolmo |
| Aug 4 | It's Always Sunny in Philadelphia | 2005 | 17 | 178 | Sitcom | Rob McElhenney |
| Aug 4 | Starved | 2005 | 1 | 7 | LGBTQ | Eric Schaeffer |
| Mar 8 | Black. White. | 2006 | 1 | 6 | Reality | |
| Mar 28 | ThiefMiniseries | 2006 | 1 | 6 | — | |
| Jan 2 | Dirt | 2007–2008 | 2 | 20 | Comedy-drama | Ronald D. Moore |
| Mar 12 | The Riches | 2007–2008 | 2 | 20 | LGBTQ | Dmitry Lipkin |
| Jul 24 | Damages | 2007–2012 | 5 | 59 | Legal drama | Todd A. Kessler |
| Sep 3 | Sons of Anarchy | 2008–2014 | 7 | 92 | Crime | Kurt Sutter |
| Sep 17 | ArcherAnimated series | 2009–2023 | 14 | 145 | Sitcom | Adam Reed |
| Oct 29 | The League | 2009–2015 | 7 | 84 | Sitcom |