| Premiere | Show | Years | Seasons | Episodes | Genre | Created by |
|---|---|---|---|---|---|---|
| Sep 11 | 2 Minute Drill | 2000–2001 | 3 | 52 | Game show | Michael Davies |
| Sep 17 | Beg, Borrow & Deal | 2002–2003 | 2 | 14 | Reality | |
| May 6 | Jim Rome Is Burning | 2003–2012 | — | 1,038 | — | |
| Aug 26 | Playmakers | 2003 | 1 | 11 | LGBTQ | John Eisendrath |
| Feb 1 | Dream Job | 2004–2006 | — | 22 | Reality | |
| — | Shaquille | 2005 | — | — | Reality | |
| Jan 13 | Tilt | 2005 | 1 | 9 | — | Brian Koppelman |
| Mar 7 | The Contender | 2005–2018 | 4 | 50 | Reality | |
| Apr 12 | Battle of the Gridiron Stars | 2005–2006 | 2 | 12 | — | |
| — | Bonds on Bonds | 2006 | — | 10 | Reality | |
| Apr 10 | The Contender Challenge: UK vs. USA | 2007 | — | — | Reality | |
| May 7 | ESPN First TakeNews program | 2007 | — | — | — | |
| May 23 | College Football Live | 2007 | — | — | — | |
| Jul 10 | The Bronx Is Burning | 2007 | 1 | 8 | — | |
| Sep 30 | Sport Science | 2007–2009 | 3 | 24 | Documentary | |
| Apr 22 | Homecoming with Rick Reilly | 2009–2010 | — | 16 | — |