| Jan 8 | Winning Lines | 2000 | 1 | 10 | Game show | |
| Jan 16 | City of Angels | 2000 | 2 | 24 | Drama | Steven Bochco |
| Apr 4 | Falcone | 2000 | 1 | 9 | Drama | |
| May 31 | Survivor | 2000 | 50 | 722 | Reality | Charlie Parsons |
| Jul 5 | Big Brother | 2000 | 28 | 1,016 | Game show | |
| Oct 1 | That's Life | 2000–2002 | 2 | 36 | Comedy-drama | Diane Ruggiero |
| Oct 2 | Yes, Dear | 2000–2006 | 6 | 122 | Sitcom | Alan Kirschenbaum |
| Oct 6 | CSI: Crime Scene Investigation | 2000–2015 | 15 | 337 | Drama | Anthony E. Zuiker, Ann Donahue |
| Oct 6 | The Fugitive | 2000–2001 | 1 | 22 | Detective | |
| Oct 7 | The District | 2000–2004 | 4 | 89 | Police procedural | Terry George |
| Oct 11 | Bette | 2000–2001 | 1 | 18 | Sitcom | Jeffrey Lane |
| Oct 11 | Welcome to New York | 2000–2001 | 1 | 16 | Sitcom | |
| Feb 24 | Kate Brasher | 2001 | 1 | 6 | — | |
| Feb 28 | Some of My Best Friends | 2001 | 1 | 7 | Sitcom | Marc Cherry |
| Mar 1 | Big Apple | 2001 | 1 | 8 | Police procedural | David Milch |
| May 13 | BlondeMiniseries | 2001 | — | 2 | Drama | |
| Sep 5 | The Amazing Race | 2001 | 32 | 373 | Game show | Bertram van Munster, Elise Doganieri |
| Sep 19 | Wolf Lake | 2001–2002 | 1 | 11 | Werewolf | |
| Sep 23 | The Education of Max Bickford | 2001–2002 | 1 | 22 | LGBTQ | |
| Sep 24 | The Ellen Show | 2001–2002 | 1 | 18 | LGBTQ | Ellen DeGeneres |
| Sep 25 | The Guardian | 2001–2004 | 3 | 67 | Drama | David Hollander |
| Sep 27 | The Agency | 2001–2003 | 2 | 44 | Drama | Michael Frost Beckner |
| Sep 28 | Danny | 2001 | 1 | 11 | Sitcom | Daniel Stern |
| Sep 29 | Citizen Baines | 2001 | 1 | 9 | Drama | Lydia Woodward |
| Dec 2 | Jim Henson's Jack and the Beanstalk: The Real StoryMiniseries | 2001 | — | 2 | Fantasy | |
| — | Gleason | 2002 | — | — | Biographical | |
| Jan 15 | First Monday | 2002 | 1 | 13 | — | Paul Levine, Donald P. Bellisario |
| Mar 18 | Baby Bob | 2002–2003 | 2 | 14 | Sitcom | |
| May 9 | CSI: Miami | 2002–2012 | 10 | 232 | Drama | Anthony E. Zuiker, Ann Donahue |
| Sep 16 | Dr. Phil | 2002–2023 | 21 | 3,505 | Talk show | Phil McGraw, Oprah Winfrey |
| Sep 24 | Presidio Med | 2002–2003 | 1 | 14 | — | John Wells |
| Sep 26 | Without a Trace | 2002–2009 | 7 | 160 | Police procedural | Hank Steinberg |
| Sep 27 | Hack | 2002–2004 | 2 | 40 | Drama | David Koepp |
| Sep 27 | Robbery Homicide Division | 2002–2003 | 1 | 13 | Police procedural | |
| Sep 30 | Still Standing | 2002–2006 | 4 | 88 | Sitcom | Joey Gutierrez, Diane Burroughs |
| Jan 10 | Queens Supreme | 2003 | 1 | 13 | Comedy-drama | |
| Feb 24 | My Big Fat Greek Life | 2003 | 1 | 7 | Sitcom | Nia Vardalos |
| Mar 11 | Strawberry ShortcakeAnimated series | 2003–2008 | 4 | 22 | Comedy | American Greetings |
| Jun 15 | Charlie Lawrence | 2003 | 1 | 7 | LGBTQ | |
| Sep 22 | Two and a Half Men | 2003–2015 | 12 | 262 | Sitcom | Chuck Lorre, Lee Aronsohn |
| Sep 23 | NCIS | 2003 | 24 | 507 | Action | Donald P. Bellisario, Don McGill |
| Sep 24 | The Brotherhood of Poland, New Hampshire | 2003 | 1 | 9 | — | David E. Kelley |
| Sep 26 | Joan of Arcadia | 2003–2005 | 2 | 45 | Fantasy | Barbara Hall |
| Sep 26 | The Handler | 2003–2004 | 1 | 16 | — | |
| Sep 28 | Cold Case | 2003–2010 | 7 | 156 | Crime | Meredith Stiehm |
| Mar 16 | Century City | 2004 | 1 | 9 | Legal drama | |
| Mar 17 | The Stones | 2004 | 1 | 9 | Sitcom | Jenji Kohan |
| Jul 7 | House Calls: The Big Brother Talk Show | 2004–2008 | 6 | — | Reality | |
| Sep 13 | The InsiderNews program | 2004–2017 | 11 | 3,221 | News magazine | |
| Sep 20 | Listen Up | 2004–2005 | 1 | 22 | Sitcom | Jeff Martin |
| Sep 22 | CSI: NY | 2004–2013 | 9 | 197 | Drama | Anthony E. Zuiker, Ann Donahue |
| Sep 24 | Dr. Vegas | 2004 | 1 | 10 | — | John Herzfeld |
| Sep 26 | Clubhouse | 2004–2005 | 1 | 11 | Drama | Daniel Cerone |
| Oct 27 | Center of the Universe | 2004–2005 | 1 | 15 | Sitcom | |
| Jan 3 | Medium | 2005–2011 | 7 | 130 | Thriller | Glenn Gordon Caron |
| Jan 3 | The Late Late Show with Craig Ferguson | 2005–2014 | 9 | 2,058 | Late-night talk show | David Letterman |
| Jan 8 | The Will | 2005 | 1 | — | Reality | Mike Fleiss |
| Jan 23 | NUMB3RS | 2005–2010 | 6 | 118 | Procedural drama | Nicolas Falacci, Cheryl Heuton |
| May 8 | ElvisMiniseries | 2005 | — | 2 | Biography | |
| Jun 7 | Fire Me...Please | 2005 | 1 | 4 | Reality | |
| Jun 9 | The Cut | 2005 | 1 | 13 | Reality | |
| Jul 11 | Rock Star: INXS | 2005 | — | — | Reality | Mark Burnett |
| Sep 16 | Threshold | 2005–2006 | 1 | 13 | Drama | |
| Sep 19 | How I Met Your Mother | 2005–2014 | 9 | 208 | Romantic comedy | Craig Thomas, Carter Bays |
| Sep 19 | Out of Practice | 2005–2006 | 1 | 22 | LGBTQ | |
| Sep 22 | Criminal Minds | 2005 | 19 | 365 | Drama | Jeff Davis |
| Sep 23 | Ghost Whisperer | 2005–2010 | 5 | 107 | Fantasy | John Gray |
| Oct 4 | Close to Home | 2005–2007 | 2 | 44 | Drama | Jim Leonard |
| Dec 4 | Pope John Paul IIMiniseries | 2005 | 1 | 2 | Biographical | |
| Jan 17 | Love Monkey | 2006 | 1 | 8 | Sitcom | |
| Jan 23 | Courting Alex | 2006 | 1 | 12 | Sitcom | Rob Hanning |
| Mar 7 | The Unit | 2006–2009 | 4 | 69 | Action | David Mamet |
| Mar 13 | The New Adventures of Old Christine | 2006–2010 | 5 | 88 | Sitcom | Kari Lizer |
| Apr 9 | Covert One: The Hades FactorMiniseries | 2006 | — | 2 | Science fiction | Robert Ludlum |
| Apr 17 | I've Got a Secret | 2006 | — | 2,006 | Panel game | Allan Sherman |
| May 31 | Gameshow Marathon | 2006 | 1 | 7 | — | |
| Jul 5 | Rock Star: Supernova | 2006 | — | 33 | Reality | |
| Sep 16 | Cake | 2006 | 1 | 13 | Teen sitcom | |
| Sep 16 | Dance Revolution | 2006–2007 | 1 | 26 | — | |
| Sep 16 | HorselandAnimated series | 2006–2008 | 3 | 39 | Animation | Andy Heyward |
| Sep 18 | The Class | 2006–2007 | 1 | 19 | Sitcom | David Crane, Jeffrey Klarik |
| Sep 19 | Smith | 2006 | 1 | 7 | Drama | John Wells |
| Sep 20 | Jericho | 2006–2008 | 2 | 29 | Action | Stephen Chbosky, Jon Turteltaub |
| Sep 21 | Shark | 2006–2008 | 2 | 38 | Legal drama | |
| Sep 25 | Comics Unleashed | 2006–2016 | — | — | Talk show | Byron Allen |
| Nov 14 | 3 lbs | 2006 | 1 | 8 | Medical drama | Peter Ocko |
| — | Beat the Blondes | 2007–2008 | 1 | — | Game show | |
| Jan 10 | Armed & Famous | 2007 | — | 6 | Reality | |
| Feb 5 | Rules of Engagement | 2007–2013 | 7 | 100 | Sitcom | |
| May 31 | Pirate Master | 2007 | 1 | 14 | Reality | Mark Burnett |
| Jun 20 | Clark and Michael | 2007 | — | 10 | — | Clark Duke |
| Aug 7 | Power of 10 | 2007 | 1 | 18 | Game show | Michael Davies |
| Sep 19 | Kid Nation | 2007 | 1 | 13 | Reality | |
| Sep 24 | The Big Bang Theory | 2007–2019 | 12 | 279 | Sitcom | Chuck Lorre, Bill Prady |
| Sep 25 | Cane | 2007 | 1 | 13 | Drama | Cynthia Cidre |
| Sep 28 | Moonlight | 2007–2008 | 1 | 16 | Thriller | |
| Oct 18 | Viva Laughlin | 2007 | 1 | 2 | Comedy | Peter Bowker |
| Nov 3 | DinoSquadAnimated series | 2007–2008 | 2 | 26 | Fantasy | |
| Jan 13 | Comanche MoonMiniseries | 2008 | — | 3 | Western | Simon Wincer |
| Feb 4 | Welcome to The Captain | 2008 | 1 | 5 | Sitcom | John Hamburg |
| Apr 8 | Secret Talents of the Stars | 2008 | 1 | 1 | Reality | |
| Jun 1 | Million Dollar Password | 2008 | 2 | — | Game show | Fremantle |
| Jun 5 | Swingtown | 2008 | 1 | 13 | Period drama | Mike Kelley |
| Jul 10 | Greatest American Dog | 2008 | 1 | 10 | Reality | |
| Jul 11 | Flashpoint | 2008–2012 | 5 | 75 | Adventure | Mark Ellis, Stephanie Morgenstern |
| Sep 22 | Worst Week | 2008–2009 | 1 | 16 | Sitcom | |
| Sep 23 | The Mentalist | 2008–2015 | 7 | 151 | Drama | Bruno Heller |
| Sep 24 | Gary Unmarried | 2008–2010 | 2 | 37 | Sitcom | |
| Oct 3 | The Ex List | 2008 | 1 | 13 | Fantasy | |
| Oct 9 | Eleventh Hour | 2008–2009 | 1 | 18 | Drama | Stephen Gallagher |
| Dec 6 | Care Bears: Adventures in Care-a-lotAnimated series | 2008 | 2 | 26 | Fantasy | |
| Jan 3 | Game Show in My Head | 2009 | 1 | 8 | — | |
| Apr 9 | Harper's IslandMiniseries | 2009 | 1 | 13 | Drama | Darren Star |
| Aug 9 | There Goes the Neighborhood | 2009 | 1 | 7 | Reality | |
| Sep 21 | Accidentally on Purpose | 2009–2010 | 1 | 18 | Sitcom | Claudia Lonow |
| Sep 22 | NCIS: Los Angeles | 2009–2023 | 14 | 323 | Action | Shane Brennan |
| Sep 22 | The Good Wife | 2009–2016 | 7 | 156 | Political drama | Michelle King, Robert King |
| Oct 4 | Three Rivers | 2009–2010 | 1 | 13 | Drama | |
| Oct 5 | Let's Make a Deal | 2009 | 6 | 1,395 | Game show | |
| Nov 9 | CSI: Trilogy | 2009 | — | 3 | Crossover | |